top-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in DNA topological change. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Is an ortholog of human TOP3A (DNA topoisomerase III alpha).