Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Is an ortholog of human ENDOG (endonuclease G).
Enables copper ion binding activity. Involved in several processes, including female pregnancy; mammary gland development; and response to copper ion. Located in cell surface and extracellular space. Used to study brain edema. Biomarker of Wilson disease; brain ischemia; heart disease; and hyperthyroidism. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin); PARTICIPATES IN hypoxia inducible factor pathway; iron efflux pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3,5-trinitro-1,3,5-triazinane.
PHENOTYPE: Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons. [provided by MGI curators]
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Predicted to enable hydrolase activity; metal ion binding activity; and nucleic acid binding activity. Is an ortholog of C. elegans cps-6. In C. elegans, cps-6 is involved in RNA catabolic process and apoptotic DNA fragmentation.
Predicted to enable hydrolase activity; metal ion binding activity; and nucleic acid binding activity. Is an ortholog of C. elegans cps-6. In C. elegans, cps-6 is involved in RNA catabolic process and apoptotic DNA fragmentation.
Enables phosphatidylinositol phosphate binding activity and small GTPase binding activity. Involved in apoptotic process; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and endosome membrane. Used to study cancer. Is an ortholog of human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1); ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2); and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3).
Predicted to enable hydrolase activity; metal ion binding activity; and nucleic acid binding activity. Is an ortholog of C. elegans cps-6. In C. elegans, cps-6 is involved in RNA catabolic process and apoptotic DNA fragmentation.