Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in plasma membrane. Expressed in PVR; cholinergic neurons; and intestine. Is an ortholog of human CRIM1 (cysteine rich transmembrane BMP regulator 1).
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]