Enables phosphatase activity. Involved in positive regulation of vulval development and vulval cell fate specification. Predicted to be located in membrane. Expressed in several structures, including P5.paa; P5.pap; P5.ppa; P5.ppp; and P7.paa. Human ortholog(s) of this gene implicated in several diseases, including breast angiosarcoma; carcinoma (multiple); and central nervous system cancer (multiple). Is an ortholog of human PTPRB (protein tyrosine phosphatase receptor type B).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of C. elegans dep-1. In C. elegans, dep-1 is involved in positive regulation of vulval development and vulval cell fate specification.
Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of C. elegans dep-1. In C. elegans, dep-1 is involved in positive regulation of vulval development and vulval cell fate specification.
Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of C. elegans dep-1. In C. elegans, dep-1 is involved in positive regulation of vulval development and vulval cell fate specification.
Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of C. elegans dep-1. In C. elegans, dep-1 is involved in positive regulation of vulval development and vulval cell fate specification.
Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of C. elegans dep-1. In C. elegans, dep-1 is involved in positive regulation of vulval development and vulval cell fate specification.
Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of C. elegans dep-1. In C. elegans, dep-1 is involved in positive regulation of vulval development and vulval cell fate specification.