alfa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in autophagy and endocytosis. Predicted to be located in autophagosome and endosome. Expressed widely. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-1. Is an ortholog of human C9orf72 (C9orf72-SMCR8 complex subunit).