acr-16 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic ion transmembrane transport. Located in cell projection. Expressed in body wall musculature; linker cell; muscle cell; and neurons. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit).