pha-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; pharynx development; and positive regulation of metabolic process. Located in nucleus. Expressed in several structures, including arcade cell; enteric muscle; gonad; pharynx; and rectum. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human FOXA1 (forkhead box A1) and FOXA2 (forkhead box A2).