tdp-1

Caenorhabditis elegans

Enables chromatin binding activity and single-stranded RNA binding activity. Involved in several processes, including RNA splicing; determination of adult lifespan; and hyperosmotic response. Located in nucleus. Expressed in several structures, including body wall musculature; intestine; muscle cell; neurons; and pharynx. Used to study amyotrophic lateral sclerosis type 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; and progressive supranuclear palsy. Is an ortholog of human TARDBP (TAR DNA binding protein).