--- count: 1 page: all query: F46E10.8 results: - allele: - class: variation id: WBVar01018798 label: gk829639 - class: variation id: WBVar01499316 label: gk963301 - class: variation id: WBVar01018795 label: gk908120 - class: variation id: WBVar01018794 label: gk529298 - class: variation id: WBVar01018796 label: gk625403 - class: variation id: WBVar01499173 label: gk963041 - class: variation id: WBVar01499174 label: gk963042 - class: variation id: WBVar00460663 label: gk237420 - class: variation id: WBVar01499496 label: gk963553 - class: variation id: WBVar01500129 label: gk964351 - class: variation id: WBVar01018801 label: gk470884 - class: variation id: WBVar01018799 label: gk633525 - class: variation id: WBVar00249566 label: tm526 - class: variation id: WBVar01018800 label: gk379080 - class: variation id: WBVar01500066 label: gk964259 - class: variation id: WBVar01018797 label: gk650513 - class: variation id: WBVar01018793 label: gk395978 - class: variation id: WBVar01499740 label: gk963850 dead: !!perl/scalar:JSON::PP::Boolean 0 description: Enables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia 79. Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). label: ubh-1 legacy_description: ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence. merged_into: ~ name: class: gene highlight: other_names: - F46E10.8 - F46E10.8 id: WBGene00006721 label: ubh-1 other_names: - F46E10.8 - CELE_F46E10.8 - F46E10.f - F46E10.8 - F46E10.8.1 - CE20818 taxonomy: c_elegans other_names: - F46E10.8 - CELE_F46E10.8 - F46E10.f - F46E10.8 - F46E10.8.1 - CE20818 page_type: gene species: key: c_elegans name: Caenorhabditis elegans taxonomy: genus: Caenorhabditis id: c_elegans species: elegans wbid: WBGene00006721 species: ~ type: gene uri: search/gene/F46E10.8/all