---
count: 1
page: all
query: F46E10.8
results:
-
allele:
-
class: variation
id: WBVar01018798
label: gk829639
-
class: variation
id: WBVar01499316
label: gk963301
-
class: variation
id: WBVar01018795
label: gk908120
-
class: variation
id: WBVar01018794
label: gk529298
-
class: variation
id: WBVar01018796
label: gk625403
-
class: variation
id: WBVar01499173
label: gk963041
-
class: variation
id: WBVar01499174
label: gk963042
-
class: variation
id: WBVar00460663
label: gk237420
-
class: variation
id: WBVar01499496
label: gk963553
-
class: variation
id: WBVar01500129
label: gk964351
-
class: variation
id: WBVar01018801
label: gk470884
-
class: variation
id: WBVar01018799
label: gk633525
-
class: variation
id: WBVar00249566
label: tm526
-
class: variation
id: WBVar01018800
label: gk379080
-
class: variation
id: WBVar01500066
label: gk964259
-
class: variation
id: WBVar01018797
label: gk650513
-
class: variation
id: WBVar01018793
label: gk395978
-
class: variation
id: WBVar01499740
label: gk963850
dead: !!perl/scalar:JSON::PP::Boolean 0
description: Enables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia 79. Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3).
label: ubh-1
legacy_description: ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence.
merged_into: ~
name:
class: gene
highlight:
other_names:
- F46E10.8
- F46E10.8
id: WBGene00006721
label: ubh-1
other_names:
- F46E10.8
- CELE_F46E10.8
- F46E10.f
- F46E10.8
- F46E10.8.1
- CE20818
taxonomy: c_elegans
other_names:
- F46E10.8
- CELE_F46E10.8
- F46E10.f
- F46E10.8
- F46E10.8.1
- CE20818
page_type: gene
species:
key: c_elegans
name: Caenorhabditis elegans
taxonomy:
genus: Caenorhabditis
id: c_elegans
species: elegans
wbid: WBGene00006721
species: ~
type: gene
uri: search/gene/F46E10.8/all