ubh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development; positive regulation of transforming growth factor beta receptor signaling pathway; and protein deneddylation. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3).