--- count: 1 page: all query: F49E8.3 results: - allele: - class: variation id: WBVar00921958 label: gk573368 - class: variation id: WBVar00921935 label: gk670408 - class: variation id: WBVar00921947 label: gk706032 - class: variation id: WBVar00921946 label: gk603485 - class: variation id: WBVar00921940 label: gk457261 - class: variation id: WBVar00094734 label: or403 - class: variation id: WBVar00921945 label: gk419789 - class: variation id: WBVar02147095 label: tm8914 - class: variation id: WBVar00428930 label: gk205687 - class: variation id: WBVar00921961 label: gk878691 - class: variation id: WBVar00921966 label: gk862722 - class: variation id: WBVar00428943 label: gk205700 - class: variation id: WBVar00094729 label: or370 - class: variation id: WBVar01499396 label: gk963417 - class: variation id: WBVar00921960 label: gk499490 - class: variation id: WBVar00428935 label: gk205692 - class: variation id: WBVar00921939 label: gk717462 - class: variation id: WBVar00921936 label: gk830894 - class: variation id: WBVar00428945 label: gk205702 - class: variation id: WBVar00921954 label: gk844907 - class: variation id: WBVar00297458 label: otn637 - class: variation id: WBVar00428933 label: gk205690 - class: variation id: WBVar02125728 label: ne4176 - class: variation id: WBVar00428937 label: gk205694 - class: variation id: WBVar00921956 label: gk566956 - class: variation id: WBVar00921963 label: gk345089 - class: variation id: WBVar01500079 label: gk964278 - class: variation id: WBVar00094721 label: or347 - class: variation id: WBVar00428938 label: gk205695 - class: variation id: WBVar00921968 label: gk429032 - class: variation id: WBVar00921949 label: gk763956 - class: variation id: WBVar00428940 label: gk205697 - class: variation id: WBVar00428942 label: gk205699 - class: variation id: WBVar00921942 label: gk605017 - class: variation id: WBVar00921952 label: gk475695 - class: variation id: WBVar01499395 label: gk963416 - class: variation id: WBVar00921953 label: gk361536 - class: variation id: WBVar00921957 label: gk395928 - class: variation id: WBVar00094709 label: or282 - class: variation id: WBVar00921965 label: gk573369 - class: variation id: WBVar00921959 label: gk683529 - class: variation id: WBVar00921962 label: gk854938 - class: variation id: WBVar00921964 label: gk791825 - class: variation id: WBVar01500245 label: gk964500 - class: variation id: WBVar00428944 label: gk205701 - class: variation id: WBVar00921955 label: gk832907 - class: variation id: WBVar00252962 label: tm4563 - class: variation id: WBVar00921967 label: gk899052 - class: variation id: WBVar00428936 label: gk205693 - class: variation id: WBVar00921943 label: gk502182 - class: variation id: WBVar00921938 label: gk611033 - class: variation id: WBVar00428934 label: gk205691 - class: variation id: WBVar00428932 label: gk205689 - class: variation id: WBVar00921944 label: gk780896 - class: variation id: WBVar00921941 label: gk481010 - class: variation id: WBVar00428941 label: gk205698 - class: variation id: WBVar00249771 label: tm742 - class: variation id: WBVar00094743 label: or547 - class: variation id: WBVar00921937 label: gk639363 - class: variation id: WBVar00428931 label: gk205688 - class: variation id: WBVar00921950 label: gk881948 - class: variation id: WBVar00921948 label: gk501629 - class: variation id: WBVar00256657 label: ttTi11613 - class: variation id: WBVar01499633 label: gk963722 - class: variation id: WBVar00428939 label: gk205696 - class: variation id: WBVar00091765 label: ok477 - class: variation id: WBVar00921951 label: gk454417 dead: !!perl/scalar:JSON::PP::Boolean 0 description: Enables metalloaminopeptidase activity. Involved in several processes, including exit from meiosis; first cell cycle pseudocleavage; and regulation of reproductive process. Located in condensed chromosome; cytoplasm; and mitotic spindle pole. Expressed in amphid process; intestine; male-specific anatomical entity; nerve ring; and tail neurons. Is an ortholog of human NPEPPS (aminopeptidase puromycin sensitive). label: pam-1 legacy_description: pam-1 encodes a metalloprotease that is the C. elegans puromycin-sensitive aminopeptidase (PSA) ortholog; in the one-cell embryo, PAM-1 is required for timely exit from meiosis II proper centrosome positioning, proper localization of polarity and cell fate determinants, and formation of the anteroposterior axis; genetic studies indicate that cyb-3, which encodes a B-type cyclin, is required for pam-1(lf) meiotic exit defects, suggesting that CYB-3 activity is regulated by PAM-1, directly or indirectly, in the early embryo; a pam-1::gfp reporter fusion is expressed in embryos, larvae, and adults; in larvae and adults, expression is particularly notable in the posterior intestine and amphid sensory neurons; in males, expression is also seen in neurons in the developing and mature male tail; in vitro, PAM-1 exhibits metal-dependent aminopeptidase activity, hydrolyzing the N-terminal amino acid from various peptide substrates. merged_into: ~ name: class: gene highlight: other_names: - F49E8.3 id: WBGene00003914 label: pam-1 other_names: - F49E8.3 - CELE_F49E8.3 - scu-1 - F49E8.3b.1 - F49E8.3a.2 - F49E8.3a.3 - CE37649 - F49E8.3a.1 - CE10790 - F49E8.3b - F49E8.3a taxonomy: c_elegans other_names: - F49E8.3 - CELE_F49E8.3 - scu-1 - F49E8.3b.1 - F49E8.3a.2 - F49E8.3a.3 - CE37649 - F49E8.3a.1 - CE10790 - F49E8.3b - F49E8.3a page_type: gene species: key: c_elegans name: Caenorhabditis elegans taxonomy: genus: Caenorhabditis id: c_elegans species: elegans wbid: WBGene00003914 species: ~ type: gene uri: search/gene/F49E8.3/all