polh-1

Caenorhabditis elegans

Predicted to enable DNA-directed DNA polymerase activity. Involved in several processes, including embryo development; error-prone translesion synthesis; and negative regulation of mitotic DNA damage checkpoint. Located in nucleus. Human ortholog(s) of this gene implicated in female breast cancer and xeroderma pigmentosum variant type. Is an ortholog of human POLH (DNA polymerase eta).