groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity.
Predicted to enable tRNA dimethylallyltransferase activity. Involved in determination of adult lifespan and regulation of growth. Located in mitochondrion and nucleus. Expressed widely. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Is an ortholog of human TRIT1 (tRNA isopentenyltransferase 1).
Predicted to be involved in tRNA processing. Is an ortholog of C. elegans gro-1. In C. elegans, gro-1 is involved in determination of adult lifespan and regulation of growth.
Predicted to be involved in tRNA processing. Is an ortholog of C. elegans gro-1. In C. elegans, gro-1 is involved in determination of adult lifespan and regulation of growth.