Hmgn1 [Search on AGR]
Rattus norvegicus Predicted to enable chromatin binding activity. Predicted to act upstream of or within several processes, including nucleotide-excision repair; post-embryonic camera-type eye morphogenesis; and response to UV. Predicted to be located in female germ cell nucleus and nucleoplasm. Predicted to be part of chromatin. Orthologous to human HMGN1 (high mobility group nucleosome binding domain 1); PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Hmgn1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele display partial embryonic lethality, increased cellular sensitivity to ultraviolet- and gamma-irradiation, increased tumor incidence and metastatic potential, increased incidence of ionizing radiation-induced tumors, and abnormal cell cycle checkpoint function. [provided by MGI curators]
Hmgn1 [Search on AGR]
Homo sapiens The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]