- Ac3 [Search on AGR]
Drosophila melanogaster Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers.
- ECM4 [Search on AGR]
Saccharomyces cerevisiae S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm
- Rab5c [Search on AGR]
Homo sapiens Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]
- gsa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including negative regulation of protein kinase C signaling; pharyngeal pumping; and positive regulation of oocyte maturation. Predicted to be part of heterotrimeric G-protein complex. Expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; Alzheimer's disease; dystonia 25; and pseudohypoparathyroidism (multiple). Is an ortholog of human GNAL (G protein subunit alpha L).
- Gsx1 [Search on AGR]
Rattus norvegicus Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Orthologous to human GSX1 (GS homeobox 1); INTERACTS WITH bisphenol A; C60 fullerene; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
- Sptssb [Search on AGR]
Homo sapiens Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
- Sptssa [Search on AGR]
Homo sapiens Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
- GLN1 [Search on AGR]
Saccharomyces cerevisiae Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress