- Frem3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele exhibit no embryonic lethality and normal fertility, size, and no apparent Fraser syndrome- or MOTA/BNAR-like developmental defects. [provided by MGI curators]
- bond [Search on AGR]
Drosophila melanogaster james bond (bond) encodes a member of the Elov1 family of enzymes that function as very long chain fatty acid elongases. It contributes to sperm generation and the production of the male sex pheromone CH503 in the ejaculatory bulb.
- Fras1 [Search on AGR]
Rattus norvegicus Predicted to be involved in cell communication. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Predicted to be located in basement membrane. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
- Frem2 [Search on AGR]
Rattus norvegicus Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; eye development; and inner ear development. Predicted to be located in basement membrane. Used to study Fraser syndrome 2. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
- Frem2 [Search on AGR]
Homo sapiens This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
- Fras1 [Search on AGR]
Homo sapiens This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]