Sema7a [Search on AGR]
Rattus norvegicus Predicted to enable integrin binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Predicted to act upstream of or within nervous system development; positive regulation of axon extension; and positive regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SEMA7A (semaphorin 7A (John Milton Hagen blood group)); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Sema7a [Search on AGR]
Homo sapiens This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]