smf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in intracellular iron ion homeostasis; manganese ion homeostasis; and response to manganese ion. Located in apical plasma membrane. Expressed in dopaminergic neurons; gonadal sheath cell; marginal cell; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); leishmaniasis (multiple); and neurodegenerative disease (multiple). Is an ortholog of human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2).