- lgs [Search on AGR]
Drosophila melanogaster legless (lgs) encodes a conserved transcriptional cofactor of the product of arm that is essential for the transcription of Wingless target genes. It contributes to growth regulation, cell survival and developmental patterning.
- Ext1 [Search on AGR]
Homo sapiens This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008]
- Bcl9 [Search on AGR]
Homo sapiens BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
- Lgsn [Search on AGR]
Homo sapiens This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
- Lg [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for spontaneous mutations exhibit open eyelids at birth with variable penetrance depending on genetic background. Mutants may develop vacuolization of the lens, as well as corneal and retinal defects. [provided by MGI curators]
- pygo [Search on AGR]
Drosophila melanogaster pygopus (pygo) encodes a key nuclear component of the Wnt signaling pathway. It facilitates the recruitment of the product of arm to Wnt-responsive genes by interacting with the transcription cofactor encoded by Chi. It also binds the product of lgs and the methylated tail of the product of His3. Together, they associate with the product of arm in a process that may function as a transition from gene silence to Wnt-induced transcription.
- Es13 [Search on AGR]
Mus musculus PHENOTYPE: This locus controls variation in Es18 in kidney. The recessive b allele is present in strains AEJ/GnRk, LG/J, SJL/J and SWR/J; the a allele occurs in all other strains tested. The locus may act by posttranslational modification of the enzyme. [provided by MGI curators]
- Capn10 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J. [provided by MGI curators]
- Epa1 [Search on AGR]
Mus musculus PHENOTYPE: This locus controls presence or absence of an epidermal antigen inducing CTL in H2 compatible hosts lacking the antigen. Antigen is present in AKR, BALB/c, CBA/J, C3H/Bi, C57BL and DBA; and absent in C3H/He, C3H/An, A/J, A/He, LG and ST/b. This locus also acts like a minor histocompatibility locus. [provided by MGI curators]