Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal small subunit assembly. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic small ribosomal subunit. Expressed in tail. Is an ortholog of human RPSA (ribosomal protein SA).
Peptidoglycan recognition protein SA (PGRP-SA) encodes a secreted protein that mediates Toll pathway activation during bacterial infection. It binds to peptidoglycans and, together with the product of GNBP1, activates the serine protease encoded by modSP.
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Expressed in hypodermis. Used to study tyrosinemia type I. Human ortholog(s) of this gene implicated in tyrosinemia type I. Is an ortholog of human FAH (fumarylacetoacetate hydrolase).
spermatocyte arrest (sa) encodes a testis binding protein associated factor involved in control of the male meiotic cycle, gene expression regulation, and spermatid differentiation.
Enables cysteine-type endopeptidase inhibitor activity. Involved in positive regulation of vitellogenesis; regulation of oocyte development; and regulation of protein processing. Located in extracellular space and yolk granule. Expressed in hypodermis; pharyngeal gland cell; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; CST3-related cerebral amyloid angiopathy; artery disease (multiple); and autoimmune disease of the nervous system (multiple). Is an ortholog of several human genes including CST1 (cystatin SN); CST2 (cystatin SA); and CST3 (cystatin C).
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
Gram-negative bacteria binding protein 1 (GNBP1) encodes a hemolymphatic protein that participates together with the product of PGRP-SA in the activation of the Toll pathway by peptidoglycans, a cell-wall component of bacteria.
Is predicted to encode a protein with the following domain: Cohesin subunit Scc3/SA. Is an ortholog of C. elegans scc-3. In C. elegans, scc-3 is involved in organelle organization and regulation of DNA damage checkpoint.