bris-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities; lung adenocarcinoma; and non-syndromic X-linked intellectual disability 1. Is an ortholog of human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1); IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); and IQSEC3 (IQ motif and Sec7 domain ArfGEF 3).