Predicted to enable transcription coactivator activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of vulval development. Located in nucleus. Expressed in several structures, including hypodermal cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); major depressive disorder; and phobic disorder. Is an ortholog of human MED12L (mediator complex subunit 12L).
Involved in lateral inhibition; positive regulation of Notch signaling pathway; and regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in body wall musculature.
Is affected by several genes including mdt-15; met-2; and spr-5 based on RNA-seq and microarray studies. Is affected by paraquat based on RNA-seq studies.
Is affected by several genes including sir-2.1; mdt-15; and drh-3 based on tiling array; microarray; and RNA-seq studies. Is affected by dibromoacetic acid based on microarray studies.
Is affected by several genes including eat-2; mdt-15; and atfs-1 based on RNA-seq studies. Is affected by seven chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.