Predicted to enable DNA-directed DNA polymerase activity. Involved in base-excision repair, gap-filling and cellular response to ionizing radiation. Predicted to be located in nucleus. Is an ortholog of human POLQ (DNA polymerase theta).
Predicted to enable clathrin adaptor activity. Involved in apical protein localization. Predicted to be located in clathrin-coated vesicle. Predicted to be part of clathrin adaptor complex. Expressed in head; nerve ring; tail; and vulva. Is an ortholog of human AP1M1 (adaptor related protein complex 1 subunit mu 1) and AP1M2 (adaptor related protein complex 1 subunit mu 2).
Involved in several processes, including DNA damage response; DNA-templated DNA replication; and germ cell proliferation. Is an ortholog of human TOPBP1 (DNA topoisomerase II binding protein 1).
Predicted to enable clathrin adaptor activity. Involved in several processes, including cilium assembly; nematode larval development; and protein localization. Predicted to be located in clathrin-coated vesicle. Predicted to be part of clathrin adaptor complex. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human AP1M1 (adaptor related protein complex 1 subunit mu 1).
Involved in lipid storage and lysosome organization. Predicted to be located in cytoplasmic vesicle. Predicted to be part of clathrin adaptor complex. Expressed in muscle cell; pharynx; spermatheca; and vulva. Is an ortholog of human AP3M1 (adaptor related protein complex 3 subunit mu 1).
Predicted to be involved in endosomal transport. Predicted to be located in several cellular components, including cytosol; late endosome; and lysosome. Predicted to be part of AP-type membrane coat adaptor complex. Orthologous to human AP5M1 (adaptor related protein complex 5 subunit mu 1); INTERACTS WITH bisphenol A; cocaine; ketamine.
Predicted to enable clathrin adaptor activity. Involved in several processes, including necroptotic process; positive regulation of Wnt protein secretion; and protein localization to non-motile cilium. Located in periciliary membrane compartment and synaptic vesicle. Expressed in anal depressor muscle; germ line; neurons; rectal epithelial cell; and spermatheca. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Is an ortholog of human AP2M1 (adaptor related protein complex 2 subunit mu 1).
Predicted to enable small GTPase binding activity. Predicted to be involved in anterograde synaptic vesicle transport. Predicted to be located in Golgi apparatus; axon cytoplasm; and cytoplasmic vesicle membrane. Predicted to be part of clathrin adaptor complex. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Predicted to be involved in endosome to melanosome transport and melanosome organization. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Is an ortholog of C. elegans mus-81. In C. elegans, mus-81 is involved in several processes, including DNA recombination; larval development; and positive regulation of embryonic development.