Predicted to enable phosphatidylinositol phosphate binding activity. Involved in endocytic recycling. Located in clathrin-coated pit. Expressed in several structures, including engulfing cell and linker cell. Is an ortholog of human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C).
Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Is an ortholog of human EHD1 (EH domain containing 1).
Enables small GTPase binding activity. Involved in endocytosis; molting cycle; and regulation of clathrin-dependent endocytosis. Located in clathrin-coated endocytic vesicle; early endosome; and plasma membrane. Expressed in several structures, including anterior gonad arm; coelomocyte; intestine; oocyte; and pharynx. Is an ortholog of human GAPVD1 (GTPase activating protein and VPS9 domains 1).
Enables low-density lipoprotein particle receptor activity. Involved in embryo development; oocyte development; and ovulation. Located in endosome membrane and plasma membrane. Expressed in germ cell; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; female reproductive organ cancer (multiple); hepatobiliary system cancer (multiple); and high grade glioma (multiple). Is an ortholog of human EGF (epidermal growth factor).
Enables identical protein binding activity. Involved in several processes, including mechanosensory behavior; positive regulation of nematode male tail tip morphogenesis; and vesicle-mediated transport. Located in endosome. Expressed in coelomocyte; hypodermal cell; muscle cell; oocyte; and uterus. Human ortholog(s) of this gene implicated in Parkinson's disease. Is an ortholog of human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13).
Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in endocytic recycling. Located in early endosome; plasma membrane; and recycling endosome membrane. Expressed in several structures, including oocyte. Is an ortholog of human RAB35 (RAB35, member RAS oncogene family).
Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Expressed in several structures, including body wall musculature; hermaphrodite gonad; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
Receptor mediated endocytosis 8 (Rme-8) encodes a protein involved in the regulation of border follicle cell migration and the endocytosis of the receptor encoded by N.
Predicted to enable calcium ion binding activity. Is an ortholog of C. elegans rme-2. In C. elegans, rme-2 is involved in embryo development; oocyte development; and ovulation.