- Dclre1c [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mutant mice exhibit a combined immunodeficiency phenotype. While immunoglobulin rearrangement is completely blocked in B cells, the block of V(D)J rearrangement in T cells is partial. [provided by MGI curators]
- Cacybp [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele exhibit reduced thymus and spleen cellularity, and defects in TCR-rearrangement. [provided by MGI curators]
- Mr1 [Search on AGR]
Mus musculus PHENOTYPE: Null homozyogtes lack mucosal-associated invariant T cells that express the canonical mVa19-Ja33 rearrangement of the Tcra gene. [provided by MGI curators]
- npp-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA binding activity. Involved in embryo development; organelle organization; and protein localization to organelle. Located in P granule; kinetochore; and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Is an ortholog of human NUP98 (nucleoporin 98 and 96 precursor).
- Poll [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective heavy chain rearrangement. See also the Dpcd gene for mutations that affect both of these overlapping genes. [provided by MGI curators]
- comt [Search on AGR]
Drosophila melanogaster comatose (comt) encodes the N-ethylmaleimide-Sensitive Factor 1 protein. It is required for maintenance of neurotransmitter release through disassembly or rearrangement of plasma membrane SNARE complexes following synaptic vesicle fusion.
- Cetn1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele show male infertility associated with oligozoospermia, teratozoospermia, immotile sperm, and altered centriole rearrangement at a late stage of spermiogenesis. [provided by MGI curators]
- Bsg [Search on AGR]
Drosophila melanogaster Basigin (Bsg) encodes an IgG family glycoprotein that promotes cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. It contributes to photoreceptor cell morphogenesis, sarcomere organization and spermatid development.
- Efa6 [Search on AGR]
Drosophila melanogaster Exchange factor for Arf 6 (Efa6) encodes a Guanine Nucleotide Exchange Factor (GEF) that sustains activation of Arf family GTPases. They are active in dynamic actin rearrangement during cell shapes changes as well as cell patterning within epithelia.