Predicted to enable cohesin loader activity and double-stranded DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Part of chromatin and cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Is an ortholog of human SMC3 (structural maintenance of chromosomes 3).
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Predicted to enable ATP binding activity. Predicted to be involved in chromosome organization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in chromosome organization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in chromosome organization and protein homooligomerization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in chromosome organization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in chromosome organization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in chromosome organization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in chromosome organization. Predicted to be located in chromosome. Is an ortholog of C. elegans smc-3.