Predicted to enable chromatin binding activity and histone binding activity. Involved in regulation of egg-laying behavior. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including hepatocellular carcinoma; seminoma; and sudden infant death syndrome. Is an ortholog of human SET (SET nuclear proto-oncogene) and SETSIP (SET like protein).
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]
Predicted to be involved in nucleosome assembly. Predicted to be located in nucleus. Is an ortholog of C. elegans spr-2. In C. elegans, spr-2 is involved in regulation of egg-laying behavior.
Predicted to be involved in nucleosome assembly. Predicted to be located in nucleus. Is an ortholog of C. elegans spr-2. In C. elegans, spr-2 is involved in regulation of egg-laying behavior.
Predicted to be involved in nucleosome assembly. Predicted to be located in nucleus. Is an ortholog of C. elegans spr-2. In C. elegans, spr-2 is involved in regulation of egg-laying behavior.
Predicted to be involved in nucleosome assembly. Predicted to be located in nucleus. Is an ortholog of C. elegans spr-2. In C. elegans, spr-2 is involved in regulation of egg-laying behavior.
Predicted to be involved in nucleosome assembly. Predicted to be located in nucleus. Is an ortholog of C. elegans spr-2. In C. elegans, spr-2 is involved in regulation of egg-laying behavior.