aak-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables AMP-activated protein kinase activity. Involved in several processes, including determination of adult lifespan; pharyngeal pumping; and regulation of protein secretion. Located in axon; cytoplasm; and neuronal cell body. Expressed in several structures, including body wall musculature; excretory canal; interfacial epithelial cell; neurons; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; colon cancer; and type 2 diabetes mellitus. Is an ortholog of human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).