rhgf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including Rho protein signal transduction; embryonic body morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in axon and cell body. Expressed in several structures, including pharyngeal cell; seam cell; somatic nervous system; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Is an ortholog of human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).