--- count: 1 page: all query: T12D8.6 results: - allele: - class: variation id: WBVar01499774 label: gk963887 - class: variation id: WBVar00876758 label: gk840088 - class: variation id: WBVar00414076 label: gk190833 - class: variation id: WBVar00414072 label: gk190829 - class: variation id: WBVar00414077 label: gk190834 - class: variation id: WBVar00414073 label: gk190830 - class: variation id: WBVar00876757 label: gk570450 - class: variation id: WBVar01498679 label: gk963904 - class: variation id: WBVar00876760 label: gk496570 - class: variation id: WBVar00414074 label: gk190831 - class: variation id: WBVar01498619 label: gk963552 - class: variation id: WBVar00876752 label: gk490171 - class: variation id: WBVar00876754 label: gk340067 - class: variation id: WBVar00876756 label: gk679110 - class: variation id: WBVar00876759 label: gk655316 - class: variation id: WBVar00876753 label: gk598456 - class: variation id: WBVar00876761 label: gk538873 - class: variation id: WBVar00876755 label: gk558849 - class: variation id: WBVar01499629 label: gk963715 - class: variation id: WBVar00414075 label: gk190832 dead: !!perl/scalar:JSON::PP::Boolean 0 description: Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). label: mlc-5 legacy_description: mlc-5 encodes a protein containing two EF-hand domains that is the C. elegans myosin II essential light chain ortholog; MLC-5 activity is required for cytokinesis and for epithelial morphogenesis during embryonic elongation; a GFP::MLC-5 fusion protein is expressed during embryogenesis in the lateral hypodermal seam cells as well as in the dorsal and ventral hypodermal cells where it exhibits co-localization with actin bundles; MLC-5 subcellular localization depends upon activity of MLC-4, a myosin regulatory light chain; in turn, MLC-5 activity is required for proper localization of MLC-4 and the non-muscle myosin II NMY-2. merged_into: ~ name: class: gene highlight: other_names: - T12D8.6 - T12D8.6 id: WBGene00011734 label: mlc-5 other_names: - T12D8.6 - CELE_T12D8.6 - CE16403 - T12D8.6.1 - T12D8.6 taxonomy: c_elegans other_names: - T12D8.6 - CELE_T12D8.6 - CE16403 - T12D8.6.1 - T12D8.6 page_type: gene species: key: c_elegans name: Caenorhabditis elegans taxonomy: genus: Caenorhabditis id: c_elegans species: elegans wbid: WBGene00011734 species: ~ type: gene uri: search/gene/T12D8.6/all