- hlh-26 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ABpla; ABplp; ABpra; and ABprp.
- tbx-38 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pharynx development. Located in nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6).
- tbx-37 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pharynx development. Located in nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6).
- hlh-27 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including ABpla; ABplp; ABprp; MSaa; and MSpa.
- lin-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including egg-laying behavior; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in apical plasma membrane and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including body wall muscle cell from M lineage; gonadal sheath cell; somatic nervous system; vulval cell; and vulval precursor cell. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); ductal carcinoma in situ; and hemangioblastoma. Is an ortholog of human NOTCH4 (notch receptor 4).
- hlh-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and positive regulation of growth rate. Located in nucleus. Expressed in several structures, including ABplapppaap; ABplapppapa; ABprapppaap; ABprapppapa; and neurons.
- ceh-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cis-regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of mesodermal cell fate specification; and regulation of asymmetric cell division. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P1.p; P2.p; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay; esophagus squamous cell carcinoma; and glaucoma. Is an ortholog of human PBX4 (PBX homeobox 4).
- tbx-35 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in cell fate specification; pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSaa; MSpa; MSpp; head neurons; and intestine.