mef-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone deacetylase binding activity. Involved in several processes, including receptor guanylyl cyclase signaling pathway; regulation of acetylcholine secretion, neurotransmission; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including hypodermis. Used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; lung cancer; and neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Is an ortholog of human MEF2A (myocyte enhancer factor 2A); MEF2C (myocyte enhancer factor 2C); and MEF2D (myocyte enhancer factor 2D).