rpt-2

Caenorhabditis elegans

Enables ubiquitin protein ligase binding activity. Involved in negative regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Expressed in head. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Is an ortholog of human PSMC1 (proteasome 26S subunit, ATPase 1).