Enriched in intestine based on tiling array; RNA-seq; and microarray studies. Is affected by several genes including
daf-2;
skn-1; and
hsf-1 based on microarray and RNA-seq studies. Is affected by sixteen chemicals including 1-methylnicotinamide; methylmercuric chloride; and Mercuric Chloride based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; and esophagus squamous cell carcinoma. Human WWOX enables enzyme binding activity and identical protein binding activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; short chain dehydrogenase; and NAD(P)-binding domain superfamily. Is an ortholog of human WWOX (WW domain containing oxidoreductase).