Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in cytoplasm and nucleus. Part of MLL3/4 complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; hermaphrodite gonad; neurons; and somatic gonad precursor. Is an ortholog of human WDR5 (WD repeat domain 5).
Is affected by several genes including daf-16; bar-1; and wdr-5.1 based on microarray and RNA-seq studies. Is affected by allantoin based on microarray studies.
Enriched in intestine based on RNA-seq studies. Is affected by several genes including cep-1; dlc-1; and wdr-5.1 based on RNA-seq studies. Is affected by paraquat based on RNA-seq studies.
Is affected by several genes including ubc-9; wdr-5.1; and pmt-2 based on microarray and RNA-seq studies. Is affected by seven chemicals including Zidovudine; Rifampin; and allantoin based on RNA-seq and microarray studies.