pfkb-1.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
ift-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in centrosome localization; intraciliary transport; and protein localization to cilium. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ciliated neurons; sensory neurons; and tail. Is an ortholog of human IFT20 (intraflagellar transport 20).
F53H1.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in recycling endosome. Is an ortholog of human DENND6A (DENN domain containing 6A) and DENND6B (DENN domain containing 6B).
trpp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cis-Golgi network and trans-Golgi network. Predicted to be part of TRAPP complex. Is an ortholog of human TRAPPC6B (trafficking protein particle complex subunit 6B).
mlc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B).
sec-15 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Expressed in embryonic cell; excretory canal; and hypodermis. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Is an ortholog of human EXOC6B (exocyst complex component 6B).
swsn-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chromatin binding activity. Predicted to be involved in nervous system development and regulation of transcription by RNA polymerase II. Predicted to be part of NuA4 histone acetyltransferase complex and SWI/SNF complex. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Is an ortholog of human ACTL6B (actin like 6B).
Myl6bl1 [Search on AGR]
Rattus norvegicus Predicted to enable calcium ion binding activity. Orthologous to human MYL6B (myosin light chain 6B).
smp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Expressed in several structures, including hook; inner labial neurons; pharyngeal cell; ray; and vulval cell. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Is an ortholog of several human genes including SEMA6A (semaphorin 6A); SEMA6B (semaphorin 6B); and SEMA6C (semaphorin 6C).
Myl6b [Search on AGR]
Rattus norvegicus Orthologous to human MYL6B (myosin light chain 6B); INTERACTS WITH 17beta-estradiol; 3H-1,2-dithiole-3-thione; acetamide.
Sult6b1 [Search on AGR]
Rattus norvegicus Orthologous to human SULT6B1 (sulfotransferase family 6B member 1); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; bisphenol A.
Y110A7A.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be located in cytoplasm. Expressed in head. Used to study high grade glioma. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder and hypogonadotropic hypogonadism 14 with or without anosmia. Is an ortholog of human WDR11 (WD repeat domain 11).
Erich6b [Search on AGR]
Rattus norvegicus Orthologous to human ERICH6B (glutamate rich 6B); INTERACTS WITH 4-hydroxyphenyl retinamide (ortholog); benzo[a]pyrene (ortholog); bisphenol A (ortholog).
Dennd6b [Search on AGR]
Rattus norvegicus Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human DENND6B (DENN domain containing 6B); INTERACTS WITH (+)-schisandrin B; 4,4'-sulfonyldiphenol; amphetamine.
mlc-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity. Located in striated muscle myosin thick filament. Expressed in head neurons; nervous system; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Is an ortholog of human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B).
CBG10826 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
Lypd6b [Search on AGR]
Rattus norvegicus Predicted to enable acetylcholine receptor regulator activity. Orthologous to human LYPD6B (LY6/PLAUR domain containing 6B); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
CJA16545 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
CJA33142 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
Bm7279 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
OVOC1708 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
CBN09578 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
CBN30778 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
PPA09691 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
Trappc6b [Search on AGR]
Rattus norvegicus Predicted to be located in endoplasmic reticulum. Orthologous to human TRAPPC6B (trafficking protein particle complex subunit 6B); INTERACTS WITH 3,4-methylenedioxymethamphetamine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
CRE19302 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
SRAE_2000115700 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Is predicted to encode a protein with the following domains: Quinoprotein alcohol dehydrogenase-like superfamily; WD40-repeat-containing domain superfamily; WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; and WD repeat-containing protein 11. Is an ortholog of C. elegans Y110A7A.9.
cct-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. Is an ortholog of human CCT6B (chaperonin containing TCP1 subunit 6B).
Kdm6b [Search on AGR]
Rattus norvegicus Enables chromatin binding activity. Involved in several processes, including hippocampus development; response to activity; and response to fungicide. Predicted to be located in nucleus. Orthologous to human KDM6B (lysine demethylase 6B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene.
Cct6b [Search on AGR]
Rattus norvegicus Predicted to enable protein folding chaperone. Predicted to be involved in protein folding. Predicted to be located in cytosol. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT6B (chaperonin containing TCP1 subunit 6B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254; bisphenol A.
Actl6b [Search on AGR]
Rattus norvegicus Involved in spinal cord development. Located in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to human ACTL6B (actin like 6B); PARTICIPATES IN SWI/SNF family mediated chromatin remodeling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Otud6b [Search on AGR]
Rattus norvegicus Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cell population proliferation; proteasome assembly; and regulation of translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human OTUD6B (OTU deubiquitinase 6B); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Sema6b [Search on AGR]
Rattus norvegicus Predicted to enable semaphorin receptor binding activity. Predicted to be involved in axon guidance and hippocampus development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SEMA6B (semaphorin 6B); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Exoc6b [Search on AGR]
Rattus norvegicus Predicted to be involved in intracellular protein transport and vesicle tethering involved in exocytosis. Predicted to be part of exocyst. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to human EXOC6B (exocyst complex component 6B); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; amitrole.
Coa6 [Search on AGR]
Homo sapiens This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Krt6c [Search on AGR]
Rattus norvegicus Predicted to be involved in intermediate filament cytoskeleton organization; morphogenesis of an epithelium; and wound healing. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to human KRT6A (keratin 6A); KRT6B (keratin 6B); and KRT6C (keratin 6C); INTERACTS WITH lead diacetate; N-nitrosomorpholine; 1-chloro-2,4-dinitrobenzene (ortholog).
Ldhal6b [Search on AGR]
Rattus norvegicus Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to be located in cytoplasm. Orthologous to human LDHAL6B (lactate dehydrogenase A like 6B); PARTICIPATES IN malonic aciduria pathway; methylmalonic aciduria, cobalamin-related pathway; propanoate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
RTEL1-TNFRSF6B [Search on AGR]
Homo sapiens This locus represents naturally occurring read-through transcription between the neighboring RTEL1 (regulator of telomere elongation helicase 1) and TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Feb 2011]
mlc-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B).
vha-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including positive regulation of apoptotic process involved in development; positive regulation of neurotransmitter secretion; and regulation of intracellular pH. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Expressed in excretory pore; hypodermal cell; muscle cell; neurons; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Is an ortholog of human ATP6V1B2 (ATPase H+ transporting V1 subunit B2).
Pde6b [Search on AGR]
Rattus norvegicus Predicted to enable metal ion binding activity. Involved in retinal cell apoptotic process. Predicted to be located in photoreceptor outer segment. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 2 and retinitis pigmentosa 40. Orthologous to human PDE6B (phosphodiesterase 6B); PARTICIPATES IN altered visual phototransduction pathway; retinitis pigmentosa pathway; visual phototransduction pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acetamide; bisphenol A.
Kat6b [Search on AGR]
Rattus norvegicus Predicted to enable histone H3K14 acetyltransferase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in bipolar disorder; blepharophimosis-intellectual disability syndrome, SBBYS type; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; atrazine.
Scn1a [Search on AGR]
Rattus norvegicus Enables sodium ion binding activity and voltage-gated sodium channel activity. Involved in neuronal action potential. Part of voltage-gated sodium channel complex. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in Dravet syndrome; developmental and epileptic encephalopathy 6B; familial hemiplegic migraine 3; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Orthologous to human SCN1A (sodium voltage-gated channel alpha subunit 1); INTERACTS WITH 1-bromopropane; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Rtel1 [Search on AGR]
Homo sapiens This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Tnrc6b [Search on AGR]
Rattus norvegicus Predicted to enable nucleic acid binding activity. Predicted to be involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Predicted to act upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in subserous uterine fibroid and uterine fibroid. Orthologous to human TNRC6B (trinucleotide repeat containing adaptor 6B); PARTICIPATES IN microRNA pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Cln6 [Search on AGR]
Rattus norvegicus Predicted to enable lysophosphatidic acid binding activity; protein homodimerization activity; and sulfatide binding activity. Predicted to be involved in several processes, including cholesterol metabolic process; ganglioside metabolic process; and lysosomal lumen acidification. Predicted to act upstream of or within several processes, including locomotion involved in locomotory behavior; lysosome organization; and visual perception. Predicted to be located in several cellular components, including early endosome; endoplasmic reticulum lumen; and membrane raft. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis; neuronal ceroid lipofuscinosis 6A; and neuronal ceroid lipofuscinosis 6B. Orthologous to human CLN6 (CLN6 transmembrane ER protein); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.