cpt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lymphangioleiomyomatosis. Is an ortholog of human CPT1A (carnitine palmitoyltransferase 1A) and CPT1C (carnitine palmitoyltransferase 1C).
ilcr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable interleukin-17 receptor activity. Involved in positive regulation of locomotion and response to oxygen levels. Located in plasma membrane. Part of receptor complex. Expressed in RMGL and RMGR. Human ortholog(s) of this gene implicated in immunodeficiency 51. Is an ortholog of human IL17RA (interleukin 17 receptor A) and IL17RB (interleukin 17 receptor B).
vha-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development; embryonic body morphogenesis; and regulation of syncytium formation by plasma membrane fusion. Located in apical junction complex and apical plasma membrane. Expressed in excretory cell; hypodermal cell; and intestine. Is an ortholog of human ATP6V0E2 (ATPase H+ transporting V0 subunit
e2).
dpy-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be part of collagen trimer. Used to study Marfan syndrome.
set-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone H3K4 methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in nucleus. Expressed in several structures, including body wall musculature; excretory cell; intestine; primary spermatocyte; and vulval muscle. Is an ortholog of human PRDM7 (PR/SET domain 7).
rpl-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is an ortholog of human RPL17 (ribosomal protein L17).
skr-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human SKP1 (S-phase kinase associated protein 1).
mec-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables tubulin N-acetyltransferase activity. Involved in mechanoreceptor differentiation and thigmotaxis. Predicted to be located in microtubule. Expressed in touch receptor neurons. Used to study neurodegenerative disease. Is an ortholog of human ATAT1 (alpha tubulin acetyltransferase 1).
unc-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of pharyngeal pumping. Located in neuron projection; organelle membrane; and synapse. Expressed in neurons;
pm2; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and congenital myasthenic syndrome 21. Is an ortholog of human SLC18A3 (solute carrier family 18 member A3).
vglu-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Predicted to be involved in several processes, including glutamatergic synaptic transmission; monoatomic anion transport; and neurotransmitter loading into synaptic vesicle. Predicted to be located in excitatory synapse. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Is an ortholog of human SLC17A6 (solute carrier family 17 member 6); SLC17A7 (solute carrier family 17 member 7); and SLC17A8 (solute carrier family 17 member 8).
hlh-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in positive regulation of dopaminergic synaptic transmission and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in CEPshDL; CEPshDR; CEPshVL; CEPshVR; and ventral cord neurons. Is an ortholog of human BHLHE22 (basic helix-loop-helix family member
e22) and BHLHE23 (basic helix-loop-helix family member
e23).
ilcr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable interleukin-17 receptor activity. Involved in positive regulation of locomotion. Located in plasma membrane. Part of receptor complex. Expressed in RMGL; RMGR; body wall musculature; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in immunodeficiency 51. Is an ortholog of human IL17RA (interleukin 17 receptor A).
prp-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Is an ortholog of human CDC40 (cell division cycle 40).
vglu-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Predicted to be involved in several processes, including glutamatergic synaptic transmission; monoatomic anion transport; and neurotransmitter loading into synaptic vesicle. Predicted to be located in excitatory synapse. Expressed in AIAL; AIAR;
hyp7 syncytium; uterine epithelial cell; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Is an ortholog of human SLC17A6 (solute carrier family 17 member 6); SLC17A7 (solute carrier family 17 member 7); and SLC17A8 (solute carrier family 17 member 8).
slc-36.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in vacuolar membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Is an ortholog of several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A4 (solute carrier family 36 member 4).
gei-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO ligase activity. Involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress. Located in metaphase plate. Part of chromatin. Expressed in motor neurons. Is an ortholog of human PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3).
mig-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables metallopeptidase activity. Involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration. Located in basement membrane and extracellular space. Expressed in several structures, including body wall musculature; gonad; head; intestine; and ventral nerve cord.
his-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Is an ortholog of several human genes including H3C1 (H3 clustered histone 1); H3C3 (H3 clustered histone 3); and H3C4 (H3 clustered histone 4).
lin-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables receptor tyrosine kinase binding activity. Involved in several processes, including axis specification; cell differentiation; and sex differentiation. Located in neuron projection membrane. Expressed in several structures, including P3.p male; P4.p male; PQR; epithelial cell; and male-specific anatomical entity.
slc-17.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in sialuria. Is an ortholog of human SLC17A5 (solute carrier family 17 member 5).
ZK829.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in male based on RNA-seq studies. Is affected by several genes including
daf-2;
daf-12; and
aak-2 based on tiling array; microarray; and RNA-seq studies. Is affected by five chemicals including Cry5B; Doxycycline; and Colistin based on microarray and proteomic studies. Human HSD17B14 enables estradiol 17-beta-dehydrogenase [NAD(P)] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; Enoyl-(Acyl carrier protein) reductase; and NAD(P)-binding domain superfamily. Is an ortholog of human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14).
snx-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in intracellular protein transport. Predicted to be located in early endosome. Is an ortholog of human SNX17 (sorting nexin 17).
F02C12.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-2;
daf-12; and
eat-2 based on tiling array; RNA-seq; and microarray studies. Is affected by six chemicals including Mercuric Chloride; Rifampin; and allantoin based on microarray and RNA-seq studies. Human HSD17B14 enables estradiol 17-beta-dehydrogenase [NAD(P)] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; Enoyl-(Acyl carrier protein) reductase; Phosphorylation site; and NAD(P)-binding domain superfamily. Is an ortholog of human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14).
gpa-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to be part of heterotrimeric G-protein complex.
ptr-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in endocytosis and molting cycle. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1).
sup-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metalloendopeptidase activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development. Located in cytoplasmic vesicle membrane and plasma membrane. Expressed in M lineage cell; hypodermis; intestinal cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease 18; colorectal cancer; and reticulate acropigmentation of Kitamura. Is an ortholog of human ADAM10 (ADAM metallopeptidase domain 10).
C06E4.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in amphid neurons; amphid sheath cell; intestine; and somatic gonad precursor based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
skn-1 based on microarray; RNA-seq; tiling array; and proteomic studies. Is affected by twenty-one chemicals including tryptophan; 1-methylnicotinamide; and methylmercuric chloride based on microarray and RNA-seq studies. Human HSD17B14 enables estradiol 17-beta-dehydrogenase [NAD(P)] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; Enoyl-(Acyl carrier protein) reductase; and NAD(P)-binding domain superfamily. Is an ortholog of human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14).
ttc-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in actin filament polymerization. Predicted to be located in actin cytoskeleton and cytoplasm. Expressed in head neurons; hypodermis; intestine; and vulva. Is an ortholog of human TTC17 (tetratricopeptide repeat domain 17).
ins-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in dauer larval development. Predicted to be located in extracellular region. Expressed in several structures, including egg-laying apparatus; gonad; head muscle; neurons; and somatic nervous system.
F26D2.15 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in several structures, including AFD; I5 neuron; germ line; head mesodermal cell; and somatic gonad precursor based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
eat-2;
clk-1; and
pgl-1 based on tiling array; microarray; and RNA-seq studies. Is affected by seven chemicals including methylmercuric chloride; multi-walled carbon nanotube; and Psoralens based on microarray and RNA-seq studies. Human HSD17B14 enables estradiol 17-beta-dehydrogenase [NAD(P)] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; Enoyl-(Acyl carrier protein) reductase; and NAD(P)-binding domain superfamily. Is an ortholog of human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14).
tmem-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in non-motile cilium assembly. Located in ciliary transition zone. Expressed in amphid neurons; ciliated neurons; inner labial neurons; outer labial neurons; and phasmid neurons. Is an ortholog of human TMEM17 (transmembrane protein 17).
B0334.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in biosynthetic process. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 5 and nuclear type mitochondrial complex I deficiency 17. Is an ortholog of human NDUFAF6 (NADH:ubiquinone oxidoreductase complex assembly factor 6).
slc-17.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Located in sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in sialuria. Is an ortholog of human SLC17A5 (solute carrier family 17 member 5).
dhhc-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable palmitoyltransferase activity. Predicted to be located in Golgi membrane. Expressed in body wall musculature and neurons. Is an ortholog of human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13) and ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17).
stdh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
metl-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in methylation and translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Is an ortholog of human METTL17 (methyltransferase like 17).
copa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport and intracellular protein transport. Predicted to be located in Golgi membrane. Predicted to be part of COPI vesicle coat. Expressed in distal tip cell and head. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Is an ortholog of human COPA (COPI coat complex subunit alpha).
stdh-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
ard-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)] activity. Predicted to be involved in androgen metabolic process; estrogen metabolic process; and fatty acid metabolic process. Predicted to be located in mitochondrion. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Alzheimer's disease; osteosarcoma; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Is an ortholog of human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10).
rbm-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Is an ortholog of human RBM17 (RNA binding motif protein 17).
hsp-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Predicted to be involved in protein refolding and response to heat. Predicted to be located in cytoplasm and nucleus. Expressed in excretory cell. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A).
vnut-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable secondary active transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in porokeratosis. Is an ortholog of human SLC17A9 (solute carrier family 17 member 9).
dhs-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in XXXL and XXXR. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; short chain dehydrogenase; and NAD(P)-binding domain superfamily.
F45G2.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Is an ortholog of human MRM2 (mitochondrial rRNA methyltransferase 2).
dhs-28 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Involved in several processes, including carbohydrate derivative metabolic process; dauer entry; and positive regulation of developmental process. Located in peroxisome. Expressed in hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4).
stdh-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
dct-13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA 3'-UTR binding activity. Predicted to be located in cytosol. Expressed in head muscle; head neurons; intestine; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2).
C35A5.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of nuclear pore. Expressed widely. Is an ortholog of human RANBP17 (RAN binding protein 17) and XPO7 (exportin 7).
gcy-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in plasma membrane. Expressed in PHAL; PHAR; and head.
rga-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rac protein signal transduction and regulation of actin cytoskeleton organization. Is an ortholog of human ARHGAP17 (Rho GTPase activating protein 17); ARHGAP44 (Rho GTPase activating protein 44); and SH3BP1 (SH3 domain binding protein 1).
citk-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metal ion binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Is an ortholog of human CIT (citron rho-interacting serine/threonine kinase).
syx-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in autophagosome membrane; endomembrane system; and plasma membrane. Predicted to be part of SNARE complex. Is an ortholog of human STX17 (syntaxin 17).
twk-37 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17).
stdh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be located in endoplasmic reticulum. Expressed in head and tail. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
egl-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in regulation of cell migration and regulation of egg-laying behavior. Located in extracellular space. Expressed in several structures, including M4 neuron; P5.p; P7.p; male-specific anatomical entity; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); hypogonadotropic hypogonadism (multiple); and prostate disease (multiple). Is an ortholog of human FGF18 (fibroblast growth factor 18) and FGF8 (fibroblast growth factor 8).
cha-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables choline O-acetyltransferase activity. Involved in acetylcholine biosynthetic process. Located in several cellular components, including cytosol; excitatory synapse; and neuronal cell body. Expressed in IL2 neuron. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Is an ortholog of human CHAT (choline O-acetyltransferase).
CHUK-DT [Search on AGR]
Homo sapiens ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 17; genetic disease
EIF5-DT [Search on AGR]
Homo sapiens ASSOCIATED WITH mitochondrial complex IV deficiency nuclear type 17
F21A3.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in several structures, including ABplppppaa; AFD; interfacial epithelial cell; rectal gland cell; and somatic gonad precursor based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including
daf-2;
skn-1; and
glp-1 based on tiling array; RNA-seq; and microarray studies. Is affected by thirteen chemicals including rotenone; D-glucose; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: ShK domain-like; Calycin; ShKT domain; THAP4-like, heme-binding beta-barrel domain; and Nitrobindin family.
Mtnap1 [Search on AGR]
Rattus norvegicus Orthologous to human C17orf80 (chromosome 17 open reading frame 80); INTERACTS WITH 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ortholog); 2-hydroxypropanoic acid (ortholog); aflatoxin B1 (ortholog).
his-29 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Is an ortholog of several human genes including H2BC12 (H2B clustered histone 12); H2BC17 (H2B clustered histone 17); and H2BC3 (H2B clustered histone 3).
cwf-19L1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Is an ortholog of human CWF19L1 (CWF19 like cell cycle control factor 1).
rps-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 4. Is an ortholog of human RPS17 (ribosomal protein S17).
ddx-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity and RNA helicase activity. Involved in pre-miRNA processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Expressed in PVDL; PVDR; and neurons. Human ortholog(s) of this gene implicated in skin squamous cell carcinoma. Is an ortholog of human DDX17 (DEAD-box helicase 17).
his-15 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in innate immune response. Predicted to be part of nucleosome. Is an ortholog of several human genes including H2BC12 (H2B clustered histone 12); H2BC17 (H2B clustered histone 17); and H2BC3 (H2B clustered histone 3).
his-44 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in innate immune response. Predicted to be part of nucleosome. Is an ortholog of several human genes including H2BC12 (H2B clustered histone 12); H2BC17 (H2B clustered histone 17); and H2BC3 (H2B clustered histone 3).
eat-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in several processes, including glutamatergic synaptic transmission; positive regulation of backward locomotion; and regulation of male mating behavior. Predicted to be located in excitatory synapse and synaptic vesicle membrane. Expressed in intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Is an ortholog of human SLC17A7 (solute carrier family 17 member 7) and SLC17A8 (solute carrier family 17 member 8).
HSD17B3-AS1 [Search on AGR]
Homo sapiens ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency; genetic disease; pseudohermaphroditism
Vom1r99 [Search on AGR]
Rattus norvegicus Orthologous to human VN1R17P (vomeronasal 1 receptor 17 pseudogene); INTERACTS WITH paracetamol.
Hsd17b14 [Search on AGR]
Rattus norvegicus Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Predicted to be involved in steroid catabolic process. Predicted to be located in cytosol. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14); INTERACTS WITH 1-naphthyl isothiocyanate; copper atom; copper(0).
drd-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Is an ortholog of several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5).
twk-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Expressed in neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5).
mdt-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Is an ortholog of human MED17 (mediator complex subunit 17).
vps-35 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in positive regulation of protein localization to cell periphery; protein localization to postsynaptic membrane; and regulation of presynapse assembly. Located in cytosol; dendrite; and neuronal cell body. Expressed in several structures, including body wall musculature; ciliated neurons; coelomocyte; intestine; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease 17. Is an ortholog of human VPS35 (VPS35 retromer complex component).
Nudt17 [Search on AGR]
Rattus norvegicus Orthologous to human NUDT17 (nudix hydrolase 17); INTERACTS WITH bisphenol A; endosulfan; furan.
twk-47 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5).
Spata17 [Search on AGR]
Rattus norvegicus Orthologous to human SPATA17 (spermatogenesis associated 17); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Wdr17 [Search on AGR]
Rattus norvegicus Orthologous to human WDR17 (WD repeat domain 17); INTERACTS WITH acrylamide; bisphenol A; Cuprizon.
twk-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Expressed in neurons and ventral nerve cord. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5).
Y39B6A.25 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in male based on RNA-seq studies. Is affected by several genes including
daf-16;
eat-2; and
clk-1 based on microarray and RNA-seq studies. Is affected by fifteen chemicals including methylmercuric chloride; manganese chloride; and multi-walled carbon nanotube based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: RING finger protein 17 and Tudor domain.
gly-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycosyltransferase activity. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in cataract 13 with adult i phenotype. Is an ortholog of several human genes including GCNT1 (glucosaminyl (N-acetyl) transferase 1); GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type); and GCNT4 (glucosaminyl (N-acetyl) transferase 4).
Dhrs11 [Search on AGR]
Homo sapiens Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
plc-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling and release of sequestered calcium ion into cytosol. Expressed in vas deferens. Human ortholog(s) of this gene implicated in Alzheimer's disease; nonsyndromic congenital nail disorder 3; and spermatogenic failure 17. Is an ortholog of human PLCD3 (phospholipase C delta 3).
LINC00605 [Search on AGR]
Homo sapiens ASSOCIATED WITH mitochondrial complex IV deficiency nuclear type 17; INTERACTS WITH entinostat; sodium arsenite; triclosan
dab-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables clathrin heavy chain binding activity and protein domain specific binding activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; egg-laying behavior; and positive regulation of growth rate. Located in cell cortex; clathrin-coated pit; and cytoplasmic vesicle. Expressed in several structures, including P5.ppp; amphid sheath cell; anchor cell; oocyte; and vulval cell. Human ortholog(s) of this gene implicated in autistic disorder and spinocerebellar ataxia type 37. Is an ortholog of human DAB1 (DAB adaptor protein 1).
atat-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables tubulin N-acetyltransferase activity. Involved in thigmotaxis. Predicted to be located in microtubule. Expressed in ciliated neurons and touch receptor neurons. Is an ortholog of human ATAT1 (alpha tubulin acetyltransferase 1).
Usp17l8 [Search on AGR]
Rattus norvegicus Orthologous to several human genes including USP17L8 (ubiquitin specific peptidase 17 like family member 8).
CBN17285 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable zinc ion binding activity. Is an ortholog of C. elegans
gei-17. In C. elegans,
gei-17 is involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress.
Cbr-gei-17 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable zinc ion binding activity. Is an ortholog of C. elegans
gei-17. In C. elegans,
gei-17 is involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress.
Ovo-gei-17 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable zinc ion binding activity. Is an ortholog of C. elegans
gei-17. In C. elegans,
gei-17 is involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress.
Ovo-mig-17 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
C2h4orf17 [Search on AGR]
Rattus norvegicus Orthologous to human C4orf17 (chromosome 4 open reading frame 17); INTERACTS WITH bisphenol A; gentamycin; trichloroethene.
Cjp-gei-17 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable zinc ion binding activity. Is an ortholog of C. elegans
gei-17. In C. elegans,
gei-17 is involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress.
Cbn-mig-17 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cjp-mig-17 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cre-mig-17 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cbn-gei-17 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable zinc ion binding activity. Is an ortholog of C. elegans
gei-17. In C. elegans,
gei-17 is involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress.
Ppa-gei-17 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable zinc ion binding activity. Is an ortholog of C. elegans
gei-17. In C. elegans,
gei-17 is involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress.
Bma-mig-17 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cbr-mig-17 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Ppa-mig-17 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
his-34 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in innate immune response. Predicted to be part of nucleosome. Is an ortholog of several human genes including H2BC12 (H2B clustered histone 12); H2BC17 (H2B clustered histone 17); and H2BC3 (H2B clustered histone 3).
rps-27 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 17. Is an ortholog of human RPS27 (ribosomal protein S27).
Ly9 [Search on AGR]
Rattus norvegicus Predicted to be involved in T-helper 17 cell lineage commitment and positive regulation of interleukin-17 production. Predicted to be located in cell surface and plasma membrane. Orthologous to human LY9 (lymphocyte antigen 9); INTERACTS WITH 1-naphthyl isothiocyanate; acetamide; amphetamine.
C10h17orf58 [Search on AGR]
Rattus norvegicus Orthologous to human C17orf58 (chromosome 17 open reading frame 58); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; buspirone.
LINC00677 [Search on AGR]
Homo sapiens ASSOCIATED WITH mitochondrial complex IV deficiency nuclear type 17; INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine
Cjp-sup-17 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Cre-lin-17 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
Bma-sup-17 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
CBN29494 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
Ovo-lin-17 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
fbxl-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in positive regulation of protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Expressed in body wall musculature and vulval muscle. Is an ortholog of human FBXL17 (F-box and leucine rich repeat protein 17).
hpr-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chromatin binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA damage checkpoint signaling; DNA repair; and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Is an ortholog of human RAD17 (RAD17 checkpoint clamp loader component).
tsp-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protease binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of egg-laying behavior; and regulation of developmental process. Located in cytoplasmic vesicle membrane and plasma membrane. Expressed in several structures, including M lineage cell; germ line; intestine; pharynx; and vulval precursor cell. Used to study cancer. Is an ortholog of human TSPAN14 (tetraspanin 14); TSPAN17 (tetraspanin 17); and TSPAN5 (tetraspanin 5).
Cbn-lin-17 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
Cbn-sup-17.2 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Cre-sup-17 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Ovo-sup-17 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Ppa-sup-17 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
ceh-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in axon guidance; positive regulation of transcription by RNA polymerase II; and regulation of axon extension. Located in nucleus. Expressed in DA8; head muscle; head neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including congenital central hypoventilation syndrome; congenital fibrosis of the extraocular muscles 2; and neuroblastoma. Is an ortholog of human PHOX2A (paired like homeobox 2A).
Cbn-sup-17.1 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
CBN31082 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
Cbr-lin-17 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
Cbr-sup-17 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
SRAE_1000290600 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
TMUE_1000002988 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Smim17 [Search on AGR]
Rattus norvegicus Orthologous to human SMIM17 (small integral membrane protein 17); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
CRE27583 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domain: Ecotropic viral integration site 5 protein. Is an ortholog of C. elegans
eat-17. In C. elegans,
eat-17 is involved in positive regulation of feeding behavior and regulation of presynaptic dense core granule exocytosis.
Hsd17b11 [Search on AGR]
Rattus norvegicus Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)] activity. Predicted to be involved in androgen catabolic process. Predicted to be located in cytoplasm and lipid droplet. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Krtap17-1 [Search on AGR]
Rattus norvegicus Orthologous to human KRTAP17-1 (keratin associated protein 17-1); INTERACTS WITH bisphenol A; trichloroethene; 17beta-estradiol (ortholog).
seip-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in lipid droplet organization and lipid storage. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 2 and hereditary spastic paraplegia 17. Is an ortholog of human BSCL2 (BSCL2 lipid droplet biogenesis associated, seipin).
dhs-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Is an ortholog of several human genes including HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); RDH16 (retinol dehydrogenase 16); and RDH5 (retinol dehydrogenase 5).
dhs-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Is an ortholog of several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5).
CJA23648 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
C10h17orf50 [Search on AGR]
Rattus norvegicus Orthologous to human C17orf50 (chromosome 17 open reading frame 50); INTERACTS WITH bisphenol A; arsane (ortholog); arsenic atom (ortholog).
TMUE_1000003332 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.
Traf3ip2 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for one null allele exhibit splenomegaly, lymphadenopathy, increased number of B cells, defective IL-17 signaling, and increased immunoglobulin levels (including auto-antibodies) whereas mice homozygous for another null allele lack these features except the defect in IL-17 signaling. [provided by MGI curators]
mask-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Predicted to be located in cytoplasm. Expressed in head. Is an ortholog of human ANKHD1 (ankyrin repeat and KH domain containing 1); ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough); and ANKRD17 (ankyrin repeat domain 17).
Il17re [Search on AGR]
Rattus norvegicus Predicted to enable interleukin-17 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and inflammatory response. Predicted to be located in plasma membrane. Orthologous to human IL17RE (interleukin 17 receptor E); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Btbd17 [Search on AGR]
Rattus norvegicus Orthologous to human BTBD17 (BTB domain containing 17); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; benzo[a]pyrene.
Cjp-lin-17 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
lin-17. In C. elegans,
lin-17 is involved in several processes, including axis specification; cell differentiation; and sex differentiation.