{"page":"all","species":null,"type":"gene","uri":"search/gene/Y46G5A.31/all","count":697,"query":"Y46G5A.31","results":[{"legacy_description":"gsy-1 is orthologous to the human gene GLYCOGEN SYNTHASE 1 (GYS1; OMIM:138570); deficiencies of GYS1 may be associated with susceptibility to type 2 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Y46G5A.34; and Y46G5A.14."]}},"taxonomy":{"genus":"Caenorhabditis","species":"japonica","id":"c_japonica"},"legacy_description":null,"label":"CJA10415","other_names":["CJA10415","JA02000","CJA10415.1","CJA10415"],"description":"Is an ortholog of C. elegans Y4C6A.4; Y46G5A.34; and Y46G5A.14.","wbid":"WBGene00129619","merged_into":null,"species":{"name":"Caenorhabditis japonica","key":"c_japonica"},"allele":null},{"legacy_description":"emb-31 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-31 mutant embryos generally arrest at the end of cell proliferation (the lima-bean stage), having exhibited abnormal gastrulation and defects in the E (gut) lineage; emb-31 escapers arrest at early larval stages and exhibit abnormal gonadogenesis; maternal emb-31 activity is necessary and sufficient for embryogenesis.","name":{"label":"emb-31","taxonomy":"c_elegans","other_names":[null],"id":"WBGene00001285","highlight":{"description_all":["emb-31 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-31 mutant embryos generally arrest at the end of cell proliferation (the","lima-bean stage), having exhibited abnormal gastrulation and defects in the E (gut) lineage; emb-31 escapers","arrest at early larval stages and exhibit abnormal gonadogenesis; maternal emb-31 activity is necessary"]},"class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"allele":[{"label":"g55","id":"WBVar00145385","class":"variation"}],"merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"label":"emb-31","wbid":"WBGene00001285","other_names":[null],"description":null},{"taxonomy":{"species":"japonica","genus":"Caenorhabditis","id":"c_japonica"},"name":{"id":"WBGene00129664","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.36 and Y46G5A.38."]},"label":"CJA10460","other_names":["CJA10460","CJA10460.1","CJA10460","JA06001"],"taxonomy":"c_japonica","class":"gene"},"page_type":"gene","dead":false,"legacy_description":null,"other_names":["CJA10460","CJA10460.1","CJA10460","JA06001"],"wbid":"WBGene00129664","description":"Is an ortholog of C. elegans Y46G5A.36 and Y46G5A.38.","label":"CJA10460","species":{"key":"c_japonica","name":"Caenorhabditis japonica"},"merged_into":null,"allele":null},{"label":"mel-31","other_names":[null],"description":null,"wbid":"WBGene00003213","merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"allele":[{"label":"s2438","id":"WBVar00242284","class":"variation"}],"page_type":"gene","name":{"highlight":{"description_all":["mel-31 was identified in screens for essential genes in the dpy-17 region of the chromosome III central","gene cluster; mel-31 is defined by a single mutation that results in variable sterility or maternal-effect","embryonic lethality; the molecular identity of mel-31 is not yet known."]},"id":"WBGene00003213","other_names":[null],"taxonomy":"c_elegans","label":"mel-31","class":"gene"},"dead":false,"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"legacy_description":"mel-31 was identified in screens for essential genes in the dpy-17 region of the chromosome III central gene cluster; mel-31 is defined by a single mutation that results in variable sterility or maternal-effect embryonic lethality; the molecular identity of mel-31 is not yet known."},{"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"page_type":"gene","name":{"label":"kin-31","other_names":["B0523.1","CELE_B0523.1","B0523.1"],"taxonomy":"c_elegans","id":"WBGene00002212","highlight":{"description_all":["kin-31 encodes a predicted tyrosine protein kinase expressed in the nucleus and cytoplasm of body-wall","muscle cells; the expression of kin-31 was experimentally verified by RT-PCR."]},"class":"gene"},"dead":false,"legacy_description":"kin-31 encodes a predicted tyrosine protein kinase expressed in the nucleus and cytoplasm of body-wall muscle cells; the expression of kin-31 was experimentally verified by RT-PCR.","other_names":["B0523.1","CELE_B0523.1","B0523.1"],"wbid":"WBGene00002212","description":"Expressed in body wall musculature.","label":"kin-31","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"allele":[{"label":"gk494630","id":"WBVar00846108","class":"variation"},{"label":"gk180620","id":"WBVar00403863","class":"variation"},{"class":"variation","label":"gk748061","id":"WBVar00846107"},{"class":"variation","id":"WBVar00846105","label":"gk834418"},{"id":"WBVar00846102","label":"gk359008","class":"variation"},{"class":"variation","id":"WBVar00403862","label":"gk180619"},{"class":"variation","label":"gk837004","id":"WBVar00846110"},{"class":"variation","id":"WBVar00403860","label":"gk180617"},{"class":"variation","id":"WBVar00249371","label":"tm323"},{"id":"WBVar00846106","label":"gk326738","class":"variation"},{"label":"gk805720","id":"WBVar00846109","class":"variation"},{"class":"variation","id":"WBVar00846103","label":"gk427972"},{"label":"gk702848","id":"WBVar00846100","class":"variation"},{"class":"variation","id":"WBVar00403864","label":"gk180621"},{"class":"variation","id":"WBVar00846099","label":"gk754918"},{"id":"WBVar00846104","label":"gk899919","class":"variation"},{"class":"variation","id":"WBVar01499774","label":"gk963887"},{"label":"gk878606","id":"WBVar00846111","class":"variation"},{"id":"WBVar00846101","label":"gk379622","class":"variation"},{"class":"variation","id":"WBVar00403859","label":"gk180616"},{"class":"variation","id":"WBVar01491036","label":"gk955299"},{"class":"variation","label":"gk369788","id":"WBVar00846098"},{"class":"variation","id":"WBVar01500260","label":"gk964518"},{"label":"gk180618","id":"WBVar00403861","class":"variation"}]},{"page_type":"gene","name":{"id":"WBGene00021834","highlight":{"description_all":["mab-31 encodes a novel protein that is highly conserved amongst nematodes; 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Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in extracellular region. 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Involved in dauer exit; determination of adult lifespan; and multicellular organism reproduction. Predicted to be part of NatA complex. Expressed in hypodermal cell and neurons. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Is an ortholog of human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit) and NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit).","wbid":"WBGene00000923","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"legacy_description":"daf-31 encodes an ortholog of the ARrest-Defective-1 protein (ARD1) that is the catalytic subunit of the major N alpha-AcetylTransferase (NatA), a heterodimeric complex that is responsible for the cotranslational N-terminal acetylation of protein substrates; loss of daf-31 activity results in constitutive formation of dauer-like larvae and fat accumulation, indicating that DAF-31 is required for dauer larval development and metabolism; in addition, daf-31 activity is required for resumption of reproductive development upon removal of dauer-inducing conditions; overexpression of DAF-31 in a daf-2 mutant background results in increased DAF-16-dependent longevity indicating a role for DAF-31 in regulation of adult lifespan, as well; DAF-31 overexpression also results in increased DAF-16 transcriptional activity, independent of an effect on DAF-16 nuclear localization; a daf-31::gfp promoter fusion is expressed from the L1 larval stage through adulthood and found in neurons, pharynx, intestine, and hypodermal cells.","name":{"id":"WBGene00000923","highlight":{"description_all":["daf-31 encodes an ortholog of the ARrest-Defective-1 protein (ARD1) that is the catalytic subunit of","that is responsible for the cotranslational N-terminal acetylation of protein substrates; loss of daf-31","is required for dauer larval development and metabolism; in addition, daf-31 activity is required for","a daf-2 mutant background results in increased DAF-16-dependent longevity indicating a role for DAF-31","activity, independent of an effect on DAF-16 nuclear localization; a daf-31::gfp promoter fusion is"]},"label":"daf-31","other_names":["K07H8.3","CELE_K07H8.3","CE18023","K07H8.3","K07H8.3.1"],"taxonomy":"c_elegans","class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"id":"c_elegans","species":"elegans","genus":"Caenorhabditis"}},{"dead":false,"page_type":"gene","name":{"label":"his-31","other_names":["F17E9.12","CELE_F17E9.12","CE03252","F17E9.12.1","F17E9.12"],"taxonomy":"c_elegans","id":"WBGene00001905","highlight":{"description_all":["his-31 encodes an H4 histone; his-31 is contained within the histone gene cluster HIS5."]},"class":"gene"},"taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"},"legacy_description":"his-31 encodes an H4 histone; his-31 is contained within the histone gene cluster HIS5.","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"label":"his-31","description":"Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Is an ortholog of several human genes including H4C1 (H4 clustered histone 1); H4C4 (H4 clustered histone 4); and H4C9 (H4 clustered histone 9).","other_names":["F17E9.12","CELE_F17E9.12","CE03252","F17E9.12.1","F17E9.12"],"wbid":"WBGene00001905","allele":[{"class":"variation","label":"gk964500","id":"WBVar01500245"},{"label":"gk964278","id":"WBVar01500079","class":"variation"},{"label":"gk963722","id":"WBVar01499633","class":"variation"},{"label":"gk962765","id":"WBVar01498996","class":"variation"},{"label":"gk963417","id":"WBVar01499396","class":"variation"}]},{"allele":null,"other_names":["CRE06092","cr01.sctg184.wum.17","CRE06092","RP26709","CRE06092.1"],"description":"Is an ortholog of C. elegans T07C12.10; Y46G5A.34; and Y4C6A.4.","wbid":"WBGene00070372","label":"CRE06092","species":{"name":"Caenorhabditis remanei","key":"c_remanei"},"merged_into":null,"legacy_description":null,"taxonomy":{"species":"remanei","genus":"Caenorhabditis","id":"c_remanei"},"name":{"class":"gene","label":"CRE06092","taxonomy":"c_remanei","other_names":["CRE06092","cr01.sctg184.wum.17","CRE06092","RP26709","CRE06092.1"],"id":"WBGene00070372","highlight":{"description_all":["Is an ortholog of C. elegans T07C12.10; Y46G5A.34; and Y4C6A.4."]}},"page_type":"gene","dead":false},{"allele":[{"class":"variation","label":"gk639367","id":"WBVar00924587"},{"label":"gk793803","id":"WBVar00924605","class":"variation"},{"class":"variation","label":"gk206530","id":"WBVar00429773"},{"id":"WBVar00429775","label":"gk206532","class":"variation"},{"class":"variation","label":"otn5912","id":"WBVar00302733"},{"id":"WBVar00429780","label":"gk206537","class":"variation"},{"class":"variation","id":"WBVar00924609","label":"gk716407"},{"class":"variation","label":"gk206541","id":"WBVar00429784"},{"class":"variation","id":"WBVar00924597","label":"gk773993"},{"class":"variation","label":"gk786073","id":"WBVar00924591"},{"label":"otn19850","id":"WBVar00316671","class":"variation"},{"class":"variation","id":"WBVar00924589","label":"gk560625"},{"label":"tm1547","id":"WBVar00250536","class":"variation"},{"class":"variation","id":"WBVar00924601","label":"gk366408"},{"class":"variation","label":"gk882967","id":"WBVar00924577"},{"class":"variation","id":"WBVar00924596","label":"gk359753"},{"label":"gk912937","id":"WBVar00924584","class":"variation"},{"id":"WBVar00924607","label":"gk528232","class":"variation"},{"label":"gk911840","id":"WBVar00924603","class":"variation"},{"class":"variation","label":"gk963416","id":"WBVar01499395"},{"class":"variation","id":"WBVar00429776","label":"gk206533"},{"class":"variation","label":"h9404","id":"WBVar02134237"},{"id":"WBVar00429778","label":"gk206535","class":"variation"},{"class":"variation","id":"WBVar00924578","label":"gk765373"},{"id":"WBVar00924588","label":"gk762102","class":"variation"},{"id":"WBVar00429777","label":"gk206534","class":"variation"},{"class":"variation","label":"gk206538","id":"WBVar00429781"},{"class":"variation","label":"gk477225","id":"WBVar00924606"},{"label":"tm3242","id":"WBVar00251987","class":"variation"},{"id":"WBVar00924600","label":"gk548195","class":"variation"},{"label":"gk477583","id":"WBVar00924595","class":"variation"},{"id":"WBVar00924582","label":"gk737888","class":"variation"},{"label":"gk206529","id":"WBVar00429772","class":"variation"},{"class":"variation","label":"gk698172","id":"WBVar00924586"},{"label":"gk963722","id":"WBVar01499633","class":"variation"},{"id":"WBVar00924590","label":"gk399777","class":"variation"},{"class":"variation","label":"gk845600","id":"WBVar00924581"},{"class":"variation","id":"WBVar00924602","label":"gk632243"},{"id":"WBVar00924598","label":"gk683201","class":"variation"},{"class":"variation","id":"WBVar00924599","label":"gk627123"},{"label":"gk718465","id":"WBVar00924579","class":"variation"},{"class":"variation","id":"WBVar00924592","label":"gk476599"},{"class":"variation","label":"gk964278","id":"WBVar01500079"},{"id":"WBVar00429782","label":"gk206539","class":"variation"},{"id":"WBVar00429779","label":"gk206536","class":"variation"},{"id":"WBVar01499396","label":"gk963417","class":"variation"},{"label":"gk206528","id":"WBVar00429771","class":"variation"},{"id":"WBVar01500245","label":"gk964500","class":"variation"},{"label":"gk539542","id":"WBVar00924604","class":"variation"},{"label":"gk946378","id":"WBVar01482119","class":"variation"},{"label":"gk885449","id":"WBVar00924608","class":"variation"},{"label":"gk829530","id":"WBVar00924580","class":"variation"},{"class":"variation","id":"WBVar00924583","label":"gk732369"},{"class":"variation","id":"WBVar00924585","label":"gk320854"},{"label":"gk789099","id":"WBVar00924593","class":"variation"},{"class":"variation","id":"WBVar00924594","label":"gk764857"},{"id":"WBVar00429783","label":"gk206540","class":"variation"},{"label":"gk206531","id":"WBVar00429774","class":"variation"},{"class":"variation","label":"tm3162","id":"WBVar00251933"}],"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"description":"Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in embryo development; post-embryonic animal morphogenesis; and response to osmotic stress. Predicted to be located in nucleus. Expressed in excretory cell.","other_names":["C26B2.3","CELE_C26B2.3","C26B2.3c.1","C26B2.3a.1","CE17474","CE37709","C26B2.3b","C26B2.3c","C26B2.3a","C26B2.3a.2"],"wbid":"WBGene00003625","label":"nhr-31","legacy_description":"nhr-31 encodes one of over 200 C. elegans nuclear receptors; nhr-31 activity is required for proper growth, development, and function of the excretory cell; in regulating excretory cell development, NHR-31 appears to function by controlling the expression of genes encoding subunits of the vacuolar ATPase; an nhr-31::gfp promoter fusion is expressed at high levels in the excretory cell beginning at embryogenesis and continuing through adulthood, with lower levels of expression seen in the intestine and unidentified tail cells.","taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"page_type":"gene","dead":false,"name":{"class":"gene","label":"nhr-31","other_names":["C26B2.3","CELE_C26B2.3","C26B2.3c.1","C26B2.3a.1","CE17474","CE37709","C26B2.3b","C26B2.3c","C26B2.3a","C26B2.3a.2"],"taxonomy":"c_elegans","id":"WBGene00003625","highlight":{"description_all":["nhr-31 encodes one of over 200 C. elegans nuclear receptors; nhr-31 activity is required for proper growth",", development, and function of the excretory cell; in regulating excretory cell development, NHR-31 appears","to function by controlling the expression of genes encoding subunits of the vacuolar ATPase; an nhr-31"]}}},{"legacy_description":null,"taxonomy":{"species":"malayi","genus":"Brugia","id":"b_malayi"},"name":{"class":"gene","other_names":["Bm6585","Bm1_02020","TAG6585","Bm1_02020A","Bm6585.1","BM03135","Bm6585"],"taxonomy":"b_malayi","label":"Bm6585","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.18."]},"id":"WBGene00226846"},"page_type":"gene","dead":false,"allele":null,"species":{"name":"Brugia malayi","key":"b_malayi"},"merged_into":null,"other_names":["Bm6585","Bm1_02020","TAG6585","Bm1_02020A","Bm6585.1","BM03135","Bm6585"],"description":"Predicted to enable nucleic acid binding activity. Is an ortholog of C. elegans Y46G5A.18.","wbid":"WBGene00226846","label":"Bm6585"},{"legacy_description":null,"taxonomy":{"id":"b_malayi","genus":"Brugia","species":"malayi"},"page_type":"gene","dead":false,"name":{"label":"Bm6587","taxonomy":"b_malayi","other_names":["Bm6587","Bm1_35360A","Bm1_35365","Bm1_35360","Bm1_35365A","TAG8161","TAG6587","BM43277","Bm6587.1","Bm6587"],"id":"WBGene00226848","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.29."]},"class":"gene"},"allele":null,"species":{"name":"Brugia malayi","key":"b_malayi"},"merged_into":null,"description":"Predicted to enable calcium ion binding activity. Is an ortholog of C. elegans Y46G5A.29.","other_names":["Bm6587","Bm1_35360A","Bm1_35365","Bm1_35360","Bm1_35365A","TAG8161","TAG6587","BM43277","Bm6587.1","Bm6587"],"wbid":"WBGene00226848","label":"Bm6587"},{"legacy_description":null,"name":{"class":"gene","other_names":["CBG18408","CBG_18408","CBP40524","CBG18408","CBG18408.1"],"taxonomy":"c_briggsae","label":"CBG18408","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.29."]},"id":"WBGene00037840"},"page_type":"gene","dead":false,"taxonomy":{"genus":"Caenorhabditis","species":"briggsae","id":"c_briggsae"},"allele":null,"merged_into":null,"species":{"name":"Caenorhabditis briggsae","key":"c_briggsae"},"label":"CBG18408","other_names":["CBG18408","CBG_18408","CBP40524","CBG18408","CBG18408.1"],"description":"Predicted to enable calcium ion binding activity. Is an ortholog of C. elegans Y46G5A.29.","wbid":"WBGene00037840"},{"species":{"name":"Caenorhabditis japonica","key":"c_japonica"},"merged_into":null,"description":"Predicted to enable nucleic acid binding activity. Is an ortholog of C. elegans Y46G5A.18.","other_names":["CJA17311","JA07404","CJA17311.1","CJA17311"],"wbid":"WBGene00136515","label":"CJA17311","allele":null,"taxonomy":{"id":"c_japonica","genus":"Caenorhabditis","species":"japonica"},"name":{"class":"gene","taxonomy":"c_japonica","other_names":["CJA17311","JA07404","CJA17311.1","CJA17311"],"label":"CJA17311","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.18."]},"id":"WBGene00136515"},"page_type":"gene","dead":false,"legacy_description":null},{"allele":null,"merged_into":null,"species":{"name":"Caenorhabditis briggsae","key":"c_briggsae"},"label":"CBG26145","description":"Is an ortholog of C. elegans pes-10; Y57A10B.6; and Y46G5A.28.","other_names":["CBG26145","CBG_26145","CBG26145"],"wbid":"WBGene00087559","legacy_description":null,"dead":false,"page_type":"gene","name":{"class":"gene","taxonomy":"c_briggsae","other_names":["CBG26145","CBG_26145","CBG26145"],"label":"CBG26145","highlight":{"description_all":["Is an ortholog of C. elegans pes-10; Y57A10B.6; and Y46G5A.28."]},"id":"WBGene00087559"},"taxonomy":{"id":"c_briggsae","genus":"Caenorhabditis","species":"briggsae"}},{"allele":null,"other_names":["CBN08942","CBN08942","CN07001","CBN08942.1"],"description":"Predicted to enable calcium ion binding activity. Is an ortholog of C. elegans Y46G5A.29.","wbid":"WBGene00147667","label":"CBN08942","species":{"key":"c_brenneri","name":"Caenorhabditis brenneri"},"merged_into":null,"legacy_description":null,"taxonomy":{"id":"c_brenneri","genus":"Caenorhabditis","species":"brenneri"},"dead":false,"page_type":"gene","name":{"taxonomy":"c_brenneri","other_names":["CBN08942","CBN08942","CN07001","CBN08942.1"],"label":"CBN08942","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.29."]},"id":"WBGene00147667","class":"gene"}},{"merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"label":"CRE24584","wbid":"WBGene00059565","other_names":["CRE24584","cr01.sctg15.wum.11","CRE24584.1","CRE24584","RP46117"],"description":"Predicted to enable nucleic acid binding activity. Is an ortholog of C. elegans Y46G5A.18.","allele":null,"page_type":"gene","dead":false,"name":{"class":"gene","label":"CRE24584","other_names":["CRE24584","cr01.sctg15.wum.11","CRE24584.1","CRE24584","RP46117"],"taxonomy":"c_remanei","id":"WBGene00059565","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.18."]}},"taxonomy":{"genus":"Caenorhabditis","species":"remanei","id":"c_remanei"},"legacy_description":null},{"legacy_description":null,"name":{"highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.18."]},"id":"WBGene00029793","other_names":["CBG07887","CBG_07887","CBG07887.1","CBG07887","CBP42572"],"taxonomy":"c_briggsae","label":"CBG07887","class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"genus":"Caenorhabditis","species":"briggsae","id":"c_briggsae"},"allele":null,"merged_into":null,"species":{"name":"Caenorhabditis briggsae","key":"c_briggsae"},"label":"CBG07887","wbid":"WBGene00029793","other_names":["CBG07887","CBG_07887","CBG07887.1","CBG07887","CBP42572"],"description":"Predicted to enable nucleic acid binding activity. Is an ortholog of C. elegans Y46G5A.18."},{"legacy_description":null,"dead":false,"page_type":"gene","name":{"class":"gene","id":"WBGene00192577","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.29."]},"label":"CBN30612","other_names":["CBN30612","CN36688","CBN30612.1","CBN30612"],"taxonomy":"c_brenneri"},"taxonomy":{"id":"c_brenneri","species":"brenneri","genus":"Caenorhabditis"},"allele":null,"label":"CBN30612","other_names":["CBN30612","CN36688","CBN30612.1","CBN30612"],"wbid":"WBGene00192577","description":"Predicted to enable calcium ion binding activity. Is an ortholog of C. elegans Y46G5A.29.","merged_into":null,"species":{"key":"c_brenneri","name":"Caenorhabditis brenneri"}},{"taxonomy":{"id":"o_volvulus","genus":"Onchocerca","species":"volvulus"},"page_type":"gene","name":{"label":"OVOC11132","taxonomy":"o_volvulus","other_names":["OVOC11132","OVP11192","OVOC11132","OVOC11132.1"],"id":"WBGene00247941","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.18."]},"class":"gene"},"dead":false,"legacy_description":null,"species":{"name":"Onchocerca volvulus","key":"o_volvulus"},"merged_into":null,"wbid":"WBGene00247941","other_names":["OVOC11132","OVP11192","OVOC11132","OVOC11132.1"],"description":"Predicted to enable nucleic acid binding activity. Is an ortholog of C. elegans Y46G5A.18.","label":"OVOC11132","allele":null},{"allele":null,"merged_into":null,"species":{"name":"Pristionchus pacificus","key":"p_pacificus"},"label":"PPA25969","wbid":"WBGene00115523","other_names":["PPA25969","GENEPREDICTION_SNAP300000086654","GENEPREDICTION_SNAP300000082821","GENEPREDICTION_SNAP300000086656","UMM-S10-77.32","PPA25969.1","PPA25969","PP68637"],"description":"Predicted to enable nucleic acid binding activity. Is an ortholog of C. elegans Y46G5A.18.","legacy_description":null,"page_type":"gene","name":{"other_names":["PPA25969","GENEPREDICTION_SNAP300000086654","GENEPREDICTION_SNAP300000082821","GENEPREDICTION_SNAP300000086656","UMM-S10-77.32","PPA25969.1","PPA25969","PP68637"],"taxonomy":"p_pacificus","label":"PPA25969","highlight":{"description_all":["Is an ortholog of C. elegans Y46G5A.18."]},"id":"WBGene00115523","class":"gene"},"dead":false,"taxonomy":{"genus":"Pristionchus","species":"pacificus","id":"p_pacificus"}},{"allele":[{"class":"variation","label":"gk141841","id":"WBVar00365084"},{"class":"variation","id":"WBVar00365083","label":"gk141840"},{"label":"gk545958","id":"WBVar00728877","class":"variation"},{"label":"gk963801","id":"WBVar01499702","class":"variation"},{"id":"WBVar01498435","label":"gk963053","class":"variation"}],"wbid":"WBGene00003429","other_names":["R05F9.13","CELE_R05F9.13","R05F9.13","CE02806","R05F9.13.1"],"description":"Expressed in gonad; oocyte; and sperm. Is predicted to encode a protein with the following domains: Major sperm protein (MSP) domain; PapD-like superfamily; MSP (Major sperm protein) domain; and Immunoglobulin-like fold.","label":"msp-31","species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"merged_into":null,"legacy_description":"msp-31 encodes a member of the major sperm protein family; msp-31 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); expression is enriched in sperm.","taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"name":{"highlight":{"description_all":["msp-31 encodes a member of the major sperm protein family; msp-31 has a C. briggsae homolog as predicted"]},"id":"WBGene00003429","other_names":["R05F9.13","CELE_R05F9.13","R05F9.13","CE02806","R05F9.13.1"],"taxonomy":"c_elegans","label":"msp-31","class":"gene"},"page_type":"gene","dead":false},{"taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"},"page_type":"gene","dead":false,"name":{"class":"gene","highlight":{"description_all":["nas-31 encodes an astacin family zinc metalloprotease with a single SXC/ShK toxin domain in addition","to the EGF and CUB domains; nas-31 is expressed in the anal depressor, intestinal, and vulval muscles"]},"id":"WBGene00003549","taxonomy":"c_elegans","other_names":["F58B4.1","CELE_F58B4.1","F58B4.1a.1","F58B4.1b","F58B4.1a","CE35882","CE35881","F58B4.1b.1"],"label":"nas-31"},"legacy_description":"nas-31 encodes an astacin family zinc metalloprotease with a single SXC/ShK toxin domain in addition to the EGF and CUB domains; nas-31 is expressed in the anal depressor, intestinal, and vulval muscles and head neurons.","description":"Predicted to enable metalloendopeptidase activity. 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may control Ca[2+]-regulated secretion of an insulin-like ligand; UNC-31 is not required for synaptic vesicle exocytosis; unc-31::gfp transcriptional reporters are expressed in most, if not all, neurons, vulval muscles, vulval cells, the spermatheca, and secretory cells such as the uterine UV1 cells; UNC-31::GFP translational fusions localize to neuronal cell bodies, axonal projections and to sites of synaptic contact, consistent with other dense-core vesicle proteins.","page_type":"gene","dead":false,"name":{"id":"WBGene00006767","highlight":{"description_all":["unc-31 encodes a pleckstrin homology (PH) domain-containing protein that is the C. elegans ortholog of","human CADPS/CAPS (calcium-dependent activator protein for secretion OMIM:604667); UNC-31 functions in","laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31","is not required for synaptic vesicle exocytosis; unc-31::gfp transcriptional reporters are expressed","vulval 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Is an ortholog of human PRPF31 (pre-mRNA processing factor 31).","other_names":["Y110A7A.8","phi-5","CELE_Y110A7A.8","CE24126","Y110A7A.8.1","Y110A7A.8"],"wbid":"WBGene00022458","merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"}},{"allele":[{"class":"variation","id":"WBVar00356672","label":"gk133429"},{"label":"gk517967","id":"WBVar00704431","class":"variation"},{"label":"gk133431","id":"WBVar00356674","class":"variation"},{"class":"variation","label":"gk676202","id":"WBVar00704438"},{"id":"WBVar00704434","label":"gk347052","class":"variation"},{"class":"variation","label":"gk963801","id":"WBVar01499702"},{"class":"variation","label":"gk133432","id":"WBVar00356675"},{"class":"variation","id":"WBVar00356671","label":"gk133428"},{"label":"gk650223","id":"WBVar00704446","class":"variation"},{"id":"WBVar00704435","label":"gk619436","class":"variation"},{"id":"WBVar00704444","label":"gk458501","class":"variation"},{"label":"gk133430","id":"WBVar00356673","class":"variation"},{"class":"variation","id":"WBVar00704433","label":"gk343406"},{"id":"WBVar00704436","label":"gk912715","class":"variation"},{"id":"WBVar00704445","label":"gk550873","class":"variation"},{"id":"WBVar00704432","label":"gk881735","class":"variation"},{"class":"variation","id":"WBVar00704442","label":"gk511070"},{"id":"WBVar00704439","label":"gk867820","class":"variation"},{"label":"gk863175","id":"WBVar00704441","class":"variation"},{"class":"variation","label":"otn6236","id":"WBVar00303057"},{"class":"variation","id":"WBVar00704440","label":"gk772841"},{"id":"WBVar00704437","label":"gk361395","class":"variation"},{"id":"WBVar01500106","label":"gk964317","class":"variation"},{"class":"variation","id":"WBVar00704443","label":"gk541506"}],"merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"label":"glb-31","other_names":["Y57G7A.9","CELE_Y57G7A.9","Y57G7A.9.1","CE19638","Y57G7A.9"],"wbid":"WBGene00021972","description":"Predicted to enable heme binding activity; oxygen binding activity; and oxygen carrier activity. 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Predicted to be involved in signal transduction. 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In C. elegans, sdz-31 is involved in gastrulation.","legacy_description":null,"name":{"class":"gene","highlight":{"description_all":["Is an ortholog of C. elegans sdz-31. In C. elegans, sdz-31 is involved in gastrulation."]},"id":"WBGene00081418","taxonomy":"c_remanei","other_names":["CRE16423","CRE16423.1","RP36603","CRE16423"],"label":"Cre-sdz-31.1"},"page_type":"gene","dead":false,"taxonomy":{"species":"remanei","genus":"Caenorhabditis","id":"c_remanei"}},{"allele":null,"merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"label":"Cre-sdz-31.2","wbid":"WBGene00081420","other_names":["CRE16440","RP40983","CRE16440","CRE16440.1"],"description":"Is an ortholog of C. elegans sdz-31. In C. elegans, sdz-31 is involved in gastrulation.","legacy_description":null,"dead":false,"page_type":"gene","name":{"class":"gene","highlight":{"description_all":["Is an ortholog of C. elegans sdz-31. 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Is an ortholog of C. elegans Y75B8A.31 and pph-4.2.","other_names":["CJA02534","JA66753","CJA02534.1","CJA02534"],"wbid":"WBGene00121738","label":"CJA02534","legacy_description":null,"taxonomy":{"species":"japonica","genus":"Caenorhabditis","id":"c_japonica"},"page_type":"gene","name":{"class":"gene","label":"CJA02534","other_names":["CJA02534","JA66753","CJA02534.1","CJA02534"],"taxonomy":"c_japonica","id":"WBGene00121738","highlight":{"description_all":["Is an ortholog of C. elegans Y75B8A.31 and pph-4.2."]}},"dead":false},{"name":{"highlight":{"description_all":["ain-1 encodes an unfamiliar protein synergistically required, withLIN-31, for the normal timing of vulval","fromretarded seam cell fusion; more prominently, ain-1(ku322) suppresses themultivulva phenotype of lin-31","(n1053) mutations, while stronglyenhancing lin-31(n1053)'s egg-laying defect; the cellular basis oflin","-31(n1053);ain-1(ku322) phenotypes is a delay in vulval developmentin L4 larvae not seen with either"]},"id":"WBGene00015547","taxonomy":"c_elegans","other_names":["C06G1.4","CELE_C06G1.4","C06G1.4","CE03967","C06G1.4.1"],"label":"ain-1","class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"},"legacy_description":"ain-1 encodes an unfamiliar protein synergistically required, withLIN-31, for the normal timing of vulval differentiation, independentlyof LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1;AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) inseveral tissues, including vulval precursor cells and neurons; AIN-1coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro,and does not require DNA or RNA for its binding; in vivo, AIN-1 targetsALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2; AIN-1 islikely to be a RISC component, since anti-AIN-1 antibodies precipitate29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77,and mir-239a; ain-1(ku322) mutants are essentially wild-type, except forsporadically gapped alae and excess seam cell nuclei arising fromretarded seam cell fusion; more prominently, ain-1(ku322) suppresses themultivulva phenotype of lin-31(n1053) mutations, while stronglyenhancing lin-31(n1053)'s egg-laying defect; the cellular basis oflin-31(n1053);ain-1(ku322) phenotypes is a delay in vulval developmentin L4 larvae not seen with either mutation alone; ain-1(ku322) has noeffect on let-60(n1046) or lin-3(e1275) mutations; ain-1(ku322)suppresses the precocious vulval development of lin-14(RNAi), lin-28mutants, and hbl-1(RNAi); alg-1 or alg-1 ain-1 mutant alae resembleain-1 alae, indicating that ALG-1 and AIN-1 act in a common geneticpathway; AIN-1 is homologous to Brugia malayi 14748.m00068,14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2;AIN-1 and its nematode homologs have weak similarity to human TNRC6A(GW182; OMIM:610739) and Drosophila GAWKY.","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"label":"ain-1","wbid":"WBGene00015547","other_names":["C06G1.4","CELE_C06G1.4","C06G1.4","CE03967","C06G1.4.1"],"description":"Involved in several processes, including embryo development; negative regulation of gene expression; and regulation of developmental process. Located in P-body. Expressed widely.","allele":[{"label":"ku327","id":"WBVar00601262","class":"variation"},{"id":"WBVar00529391","label":"gk306148","class":"variation"},{"class":"variation","id":"WBVar00529389","label":"gk306146"},{"label":"gk340274","id":"WBVar01223174","class":"variation"},{"id":"WBVar01223179","label":"gk812758","class":"variation"},{"class":"variation","id":"WBVar00601261","label":"ku425"},{"class":"variation","label":"gk928858","id":"WBVar01223173"},{"label":"gk350062","id":"WBVar01223186","class":"variation"},{"class":"variation","label":"gk432006","id":"WBVar01223175"},{"class":"variation","label":"gk811342","id":"WBVar01223185"},{"label":"gk764694","id":"WBVar01223180","class":"variation"},{"id":"WBVar00529393","label":"gk306150","class":"variation"},{"class":"variation","id":"WBVar01223202","label":"gk584812"},{"class":"variation","id":"WBVar01223183","label":"gk390016"},{"label":"gk358888","id":"WBVar01223195","class":"variation"},{"id":"WBVar01223187","label":"gk329294","class":"variation"},{"label":"gk306147","id":"WBVar00529390","class":"variation"},{"id":"WBVar01499519","label":"gk963581","class":"variation"},{"class":"variation","label":"gk963810","id":"WBVar01499710"},{"id":"WBVar01500067","label":"gk964260","class":"variation"},{"class":"variation","id":"WBVar01498960","label":"gk962707"},{"class":"variation","label":"ku322","id":"WBVar00088360"},{"class":"variation","id":"WBVar01223189","label":"gk817825"},{"id":"WBVar01223192","label":"gk504579","class":"variation"},{"class":"variation","label":"gk429300","id":"WBVar01223200"},{"id":"WBVar01223177","label":"gk703734","class":"variation"},{"id":"WBVar01223198","label":"gk768886","class":"variation"},{"class":"variation","id":"WBVar01223181","label":"gk872272"},{"label":"gk597704","id":"WBVar01223193","class":"variation"},{"class":"variation","label":"gk890900","id":"WBVar01223190"},{"label":"gk702687","id":"WBVar01223196","class":"variation"},{"label":"gk434320","id":"WBVar01223188","class":"variation"},{"label":"gk500868","id":"WBVar01223204","class":"variation"},{"class":"variation","label":"bp299","id":"WBVar00296578"},{"label":"gk499733","id":"WBVar01223191","class":"variation"},{"class":"variation","label":"gk908344","id":"WBVar01223203"},{"id":"WBVar01223184","label":"gk827128","class":"variation"},{"class":"variation","label":"gk460210","id":"WBVar01223199"},{"class":"variation","label":"gk857240","id":"WBVar01223182"},{"class":"variation","id":"WBVar01223176","label":"gk893676"},{"label":"gk729943","id":"WBVar01223201","class":"variation"},{"class":"variation","id":"WBVar01223197","label":"gk468570"},{"label":"tm3681","id":"WBVar00252299","class":"variation"},{"class":"variation","id":"WBVar01223194","label":"gk878923"},{"class":"variation","id":"WBVar01223178","label":"gk448612"},{"id":"WBVar00529392","label":"gk306149","class":"variation"}]},{"dead":false,"page_type":"gene","name":{"class":"gene","highlight":{"description_all":["Is an ortholog of C. elegans gcy-31. In C. elegans, gcy-31 is involved in response to oxygen levels."]},"id":"WBGene00190648","taxonomy":"c_brenneri","other_names":["CBN28683","CBN28683.1","CN32360","CBN28683"],"label":"Cbn-gcy-31"},"taxonomy":{"id":"c_brenneri","species":"brenneri","genus":"Caenorhabditis"},"legacy_description":null,"label":"Cbn-gcy-31","other_names":["CBN28683","CBN28683.1","CN32360","CBN28683"],"wbid":"WBGene00190648","description":"Predicted to enable guanylate cyclase activity and heme binding activity. Predicted to be involved in cGMP biosynthetic process and intracellular signal transduction. Is an ortholog of C. elegans gcy-31. In C. elegans, gcy-31 is involved in response to oxygen levels.","merged_into":null,"species":{"key":"c_brenneri","name":"Caenorhabditis brenneri"},"allele":null},{"label":"Cbr-lin-31","description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","other_names":["CBG18439","CBG_18439","CBG18439","CBG18439.1","CBP04362"],"wbid":"WBGene00037861","merged_into":null,"species":{"key":"c_briggsae","name":"Caenorhabditis briggsae"},"allele":null,"name":{"class":"gene","id":"WBGene00037861","highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]},"label":"Cbr-lin-31","other_names":["CBG18439","CBG_18439","CBG18439","CBG18439.1","CBP04362"],"taxonomy":"c_briggsae"},"page_type":"gene","dead":false,"taxonomy":{"species":"briggsae","genus":"Caenorhabditis","id":"c_briggsae"},"legacy_description":null},{"allele":null,"label":"Cjp-lin-31","wbid":"WBGene00137835","other_names":["CJA18631","JA60643","CJA18631.1","CJA18631"],"description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","merged_into":null,"species":{"key":"c_japonica","name":"Caenorhabditis japonica"},"legacy_description":null,"name":{"class":"gene","label":"Cjp-lin-31","taxonomy":"c_japonica","other_names":["CJA18631","JA60643","CJA18631.1","CJA18631"],"id":"WBGene00137835","highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]}},"page_type":"gene","dead":false,"taxonomy":{"genus":"Caenorhabditis","species":"japonica","id":"c_japonica"}},{"other_names":["TMUE_1000003748","TMUE_s0032000300","TMUE_1000003748.1","TMP02003","TMUE_1000003748"],"description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","wbid":"WBGene00288745","label":"TMUE_1000003748","species":{"name":"Trichuris muris","key":"t_muris"},"merged_into":null,"allele":null,"taxonomy":{"species":"muris","genus":"Trichuris","id":"t_muris"},"page_type":"gene","name":{"highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]},"id":"WBGene00288745","other_names":["TMUE_1000003748","TMUE_s0032000300","TMUE_1000003748.1","TMP02003","TMUE_1000003748"],"taxonomy":"t_muris","label":"TMUE_1000003748","class":"gene"},"dead":false,"legacy_description":null},{"page_type":"gene","name":{"taxonomy":"p_pacificus","other_names":["PPA08535","UMM-S13-16.49","GENEPREDICTION_SNAP300000065020","PPA08535","PPA08535.1","PP51680"],"label":"PPA08535","highlight":{"description_all":["Is an ortholog of C. elegans T28H11.7; Y47D3A.31; and ZC477.7."]},"id":"WBGene00098089","class":"gene"},"dead":false,"taxonomy":{"species":"pacificus","genus":"Pristionchus","id":"p_pacificus"},"legacy_description":null,"label":"PPA08535","other_names":["PPA08535","UMM-S13-16.49","GENEPREDICTION_SNAP300000065020","PPA08535","PPA08535.1","PP51680"],"description":"Predicted to be located in cytoplasm. Is an ortholog of C. elegans T28H11.7; Y47D3A.31; and ZC477.7.","wbid":"WBGene00098089","merged_into":null,"species":{"key":"p_pacificus","name":"Pristionchus pacificus"},"allele":null},{"dead":false,"page_type":"gene","name":{"highlight":{"description_all":["Is an ortholog of C. elegans gcy-31. In C. elegans, gcy-31 is involved in response to oxygen levels."]},"id":"WBGene00058156","taxonomy":"c_remanei","other_names":["CRE07380","cr01.sctg11.wum.10","CRE07380","RP30638","CRE07380.1"],"label":"Cre-gcy-31","class":"gene"},"taxonomy":{"genus":"Caenorhabditis","species":"remanei","id":"c_remanei"},"legacy_description":null,"label":"Cre-gcy-31","other_names":["CRE07380","cr01.sctg11.wum.10","CRE07380","RP30638","CRE07380.1"],"wbid":"WBGene00058156","description":"Predicted to enable guanylate cyclase activity and heme binding activity. Predicted to be involved in cGMP biosynthetic process and intracellular signal transduction. Is an ortholog of C. elegans gcy-31. In C. elegans, gcy-31 is involved in response to oxygen levels.","merged_into":null,"species":{"name":"Caenorhabditis remanei","key":"c_remanei"},"allele":null},{"allele":null,"other_names":["PPA39541","PPA39541.1","PP51273","PPA39541"],"description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","wbid":"WBGene00277910","label":"PPA39541","species":{"key":"p_pacificus","name":"Pristionchus pacificus"},"merged_into":null,"legacy_description":null,"taxonomy":{"species":"pacificus","genus":"Pristionchus","id":"p_pacificus"},"dead":false,"page_type":"gene","name":{"label":"PPA39541","other_names":["PPA39541","PPA39541.1","PP51273","PPA39541"],"taxonomy":"p_pacificus","id":"WBGene00277910","highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]},"class":"gene"}},{"label":"SRAE_X000245600","other_names":["SRAE_X000245600","SRAE_X000245600.1","SRAE_X000245600","SRP03737"],"description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","wbid":"WBGene00268042","merged_into":null,"species":{"name":"Strongyloides ratti","key":"s_ratti"},"allele":null,"page_type":"gene","name":{"id":"WBGene00268042","highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]},"label":"SRAE_X000245600","other_names":["SRAE_X000245600","SRAE_X000245600.1","SRAE_X000245600","SRP03737"],"taxonomy":"s_ratti","class":"gene"},"dead":false,"taxonomy":{"species":"ratti","genus":"Strongyloides","id":"s_ratti"},"legacy_description":null},{"taxonomy":{"id":"b_malayi","genus":"Brugia","species":"malayi"},"name":{"id":"WBGene00230666","highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]},"label":"Bma-lin-31","taxonomy":"b_malayi","other_names":["Bm10405","TAG10405","BM40112","Bm10405","Bm10405.1"],"class":"gene"},"page_type":"gene","dead":false,"legacy_description":null,"species":{"name":"Brugia malayi","key":"b_malayi"},"merged_into":null,"other_names":["Bm10405","TAG10405","BM40112","Bm10405","Bm10405.1"],"description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","wbid":"WBGene00230666","label":"Bma-lin-31","allele":null},{"legacy_description":null,"page_type":"gene","dead":false,"name":{"class":"gene","id":"WBGene00025231","highlight":{"description_all":["Is an ortholog of C. elegans gcy-31. In C. elegans, gcy-31 is involved in response to oxygen levels."]},"label":"Cbr-gcy-31","other_names":["CBG02110","CBG_02110","CBG02110.1","CBP43037","CBG02110"],"taxonomy":"c_briggsae"},"taxonomy":{"id":"c_briggsae","genus":"Caenorhabditis","species":"briggsae"},"allele":null,"label":"Cbr-gcy-31","description":"Predicted to enable guanylate cyclase activity and heme binding activity. Predicted to be involved in cGMP biosynthetic process and intracellular signal transduction. Is an ortholog of C. elegans gcy-31. In C. elegans, gcy-31 is involved in response to oxygen levels.","other_names":["CBG02110","CBG_02110","CBG02110.1","CBP43037","CBG02110"],"wbid":"WBGene00025231","merged_into":null,"species":{"name":"Caenorhabditis briggsae","key":"c_briggsae"}},{"legacy_description":null,"page_type":"gene","dead":false,"name":{"highlight":{"description_all":["Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development."]},"id":"WBGene00061465","other_names":["CRE20476","cr01.sctg24.wum.71","CRE20476.1","CRE20476","RP16973"],"taxonomy":"c_remanei","label":"Cre-lin-31","class":"gene"},"taxonomy":{"id":"c_remanei","species":"remanei","genus":"Caenorhabditis"},"allele":null,"merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"label":"Cre-lin-31","other_names":["CRE20476","cr01.sctg24.wum.71","CRE20476.1","CRE20476","RP16973"],"description":"Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans lin-31. In C. elegans, lin-31 is involved in vulval development.","wbid":"WBGene00061465"},{"page_type":"gene","dead":false,"name":{"label":"CRE30127","taxonomy":"c_remanei","other_names":["CRE30127","cr01.sctg96.wum.6","CRE30127.1","CRE30127","RP01695"],"id":"WBGene00067497","highlight":{"description_all":["Is an ortholog of C. elegans hlh-31 and hlh-32."]},"class":"gene"},"taxonomy":{"id":"c_remanei","genus":"Caenorhabditis","species":"remanei"},"legacy_description":null,"label":"CRE30127","wbid":"WBGene00067497","other_names":["CRE30127","cr01.sctg96.wum.6","CRE30127.1","CRE30127","RP01695"],"description":"Predicted to enable protein dimerization activity. Is an ortholog of C. elegans hlh-31 and hlh-32.","merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"allele":null},{"page_type":"gene","dead":false,"name":{"class":"gene","other_names":[null],"taxonomy":"r_norvegicus","label":"Lrrc31","highlight":{"description_all":["Orthologous to human LRRC31 (leucine rich repeat containing 31); INTERACTS WITH 4,4'-sulfonyldiphenol"]},"id":"RGD:1561499"},"taxonomy":{"id":"r_norvegicus","genus":"Rattus","species":"norvegicus"},"legacy_description":null,"label":"Lrrc31","wbid":"RGD:1561499","other_names":[null],"description":"Orthologous to human LRRC31 (leucine rich repeat containing 31); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.","merged_into":null,"species":{"key":"r_norvegicus","name":"Rattus norvegicus"},"allele":null},{"legacy_description":"F21A3.3 encodes a putatively secreted protein, with an N-terminalEGF-liked domain and a DUF1794 domain, that is homologous to humanTHAP4/CGI-36; F21A3.3 is a paralog of MAB-7, C15F1.1, C28H8.5, C52G5.2,T28H10.2, and a domain in Y46G5A.29.","taxonomy":{"id":"c_elegans","species":"elegans","genus":"Caenorhabditis"},"name":{"label":"F21A3.3","taxonomy":"c_elegans","other_names":["F21A3.3","CELE_F21A3.3","F21A3.3","F21A3.3.1","CE40043"],"id":"WBGene00008993","highlight":{"description_all":["humanTHAP4/CGI-36; F21A3.3 is a paralog of MAB-7, C15F1.1, C28H8.5, C52G5.2,T28H10.2, and a domain in Y46G5A"]},"class":"gene"},"page_type":"gene","dead":false,"allele":[{"class":"variation","label":"tm12721","id":"WBVar02150274"},{"class":"variation","id":"WBVar01500213","label":"gk964459"},{"class":"variation","id":"WBVar01074262","label":"gk697258"},{"label":"gk817068","id":"WBVar01074272","class":"variation"},{"label":"gk673575","id":"WBVar01074268","class":"variation"},{"class":"variation","label":"gk633985","id":"WBVar01074260"},{"class":"variation","id":"WBVar01074265","label":"gk769627"},{"label":"gk831712","id":"WBVar01074264","class":"variation"},{"id":"WBVar01074263","label":"gk931151","class":"variation"},{"class":"variation","id":"WBVar01074269","label":"gk374536"},{"label":"gk963271","id":"WBVar01499299","class":"variation"},{"id":"WBVar00598983","label":"gk310654","class":"variation"},{"class":"variation","label":"gk964458","id":"WBVar01500212"},{"class":"variation","id":"WBVar01074261","label":"gk581546"},{"label":"gk255958","id":"WBVar00479201","class":"variation"},{"label":"gk255959","id":"WBVar00479202","class":"variation"},{"label":"gk255961","id":"WBVar00479204","class":"variation"},{"id":"WBVar01074276","label":"gk416390","class":"variation"},{"class":"variation","label":"gk255957","id":"WBVar00479200"},{"class":"variation","label":"gk255962","id":"WBVar00479205"},{"class":"variation","id":"WBVar01074267","label":"gk442321"},{"class":"variation","id":"WBVar01074270","label":"gk766774"},{"class":"variation","id":"WBVar01074271","label":"gk589537"},{"id":"WBVar01074275","label":"gk700893","class":"variation"},{"class":"variation","id":"WBVar01074266","label":"gk464955"},{"class":"variation","id":"WBVar00479199","label":"gk255956"},{"id":"WBVar01074273","label":"gk634961","class":"variation"},{"id":"WBVar01499316","label":"gk963301","class":"variation"},{"label":"gk738145","id":"WBVar01074274","class":"variation"},{"id":"WBVar01500160","label":"gk964389","class":"variation"},{"label":"tm2276","id":"WBVar00251185","class":"variation"},{"label":"gk255960","id":"WBVar00479203","class":"variation"}],"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"merged_into":null,"other_names":["F21A3.3","CELE_F21A3.3","F21A3.3","F21A3.3.1","CE40043"],"wbid":"WBGene00008993","description":"Enriched in several structures, including ABplppppaa; AFD; interfacial epithelial cell; rectal gland cell; and somatic gonad precursor based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-2; skn-1; and glp-1 based on tiling array; RNA-seq; and microarray studies. Is affected by thirteen chemicals including rotenone; D-glucose; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: ShKT domain; Nitrobindin family; ShK domain-like; THAP4-like, heme-binding beta-barrel domain; and Calycin.","label":"F21A3.3"},{"page_type":"gene","name":{"class":"gene","highlight":{"description_all":["Is an ortholog of C. elegans lin-31. 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Is an ortholog of C. elegans nas-31.","label":"SRAE_0000021610","species":{"key":"s_ratti","name":"Strongyloides ratti"},"merged_into":null,"legacy_description":null,"taxonomy":{"id":"s_ratti","genus":"Strongyloides","species":"ratti"},"page_type":"gene","name":{"label":"SRAE_0000021610","taxonomy":"s_ratti","other_names":["SRAE_0000021610","SR01715","SRAE_0000021610.1","SRAE_0000021610","SRP02010"],"id":"WBGene00255956","highlight":{"description_all":["Is an ortholog of C. elegans nas-31."]},"class":"gene"},"dead":false},{"label":"Ppa-dpy-31","wbid":"WBGene00107430","other_names":["PPA17876","GENEPREDICTION_SNAP300000074580","Ppa-lgc-50","UMM-S2874-4.35","GENEPREDICTION_SNAP300000074579","PPA17876.1","PPA17876","PP59090"],"description":"Predicted to enable extracellular ligand-gated monoatomic ion channel activity; metalloendopeptidase activity; and zinc ion binding activity. Predicted to be involved in monoatomic ion transport and proteolysis. Predicted to be located in membrane. 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Is an ortholog of C. elegans nas-31.","merged_into":null,"species":{"key":"c_brenneri","name":"Caenorhabditis brenneri"},"allele":null,"page_type":"gene","dead":false,"name":{"class":"gene","id":"WBGene00158440","highlight":{"description_all":["Is an ortholog of C. elegans nas-31."]},"label":"Cbn-nas-31","taxonomy":"c_brenneri","other_names":["CBN19715","CBN19715","CBN19715","CN18472","CBN19715.1"]},"taxonomy":{"id":"c_brenneri","genus":"Caenorhabditis","species":"brenneri"},"legacy_description":null},{"taxonomy":{"id":"s_ratti","species":"ratti","genus":"Strongyloides"},"page_type":"gene","name":{"class":"gene","id":"WBGene00264772","highlight":{"description_all":["Is an ortholog of C. elegans nas-31."]},"label":"SRAE_2000454000","other_names":["SRAE_2000454000","SRP04242","SRAE_2000454000.1","SRAE_2000454000"],"taxonomy":"s_ratti"},"dead":false,"legacy_description":null,"species":{"key":"s_ratti","name":"Strongyloides ratti"},"merged_into":null,"description":"Predicted to enable metalloendopeptidase activity and zinc ion binding activity. 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Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in membrane. Is an ortholog of C. elegans srg-36; srg-34; and srg-31.","label":"PPA39340","species":{"key":"p_pacificus","name":"Pristionchus pacificus"},"merged_into":null},{"legacy_description":null,"taxonomy":{"genus":"Pristionchus","species":"pacificus","id":"p_pacificus"},"page_type":"gene","dead":false,"name":{"label":"PPA40497","other_names":["PPA40497","PPA40497","PPA40497.1","PP65890"],"taxonomy":"p_pacificus","id":"WBGene00278866","highlight":{"description_all":["Is an ortholog of C. elegans srg-36; srg-34; and srg-31."]},"class":"gene"},"allele":null,"species":{"name":"Pristionchus pacificus","key":"p_pacificus"},"merged_into":null,"description":"Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in membrane. 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Is an ortholog of C. elegans srx-133.","label":"Cbn-srx-133","allele":null,"taxonomy":{"id":"c_brenneri","species":"brenneri","genus":"Caenorhabditis"},"page_type":"gene","name":{"class":"gene","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"id":"WBGene00139146","taxonomy":"c_brenneri","other_names":["CBN00421","CBN00421","CBN00421","CBN00421.1","CN15064"],"label":"Cbn-srx-133"},"dead":false,"legacy_description":null},{"merged_into":null,"species":{"key":"c_brenneri","name":"Caenorhabditis brenneri"},"label":"Cbn-srx-134","other_names":["CBN17623","CBN17623","CBN17623.1","CN19313","CBN17623"],"description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-134.","wbid":"WBGene00156348","allele":null,"dead":false,"page_type":"gene","name":{"class":"gene","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"id":"WBGene00156348","other_names":["CBN17623","CBN17623","CBN17623.1","CN19313","CBN17623"],"taxonomy":"c_brenneri","label":"Cbn-srx-134"},"taxonomy":{"genus":"Caenorhabditis","species":"brenneri","id":"c_brenneri"},"legacy_description":null},{"allele":null,"other_names":["CBN13762","CBN13762","CBN13762","CBN13762.1","CN14351"],"wbid":"WBGene00152487","description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-136.","label":"Cbn-srx-136","species":{"key":"c_brenneri","name":"Caenorhabditis brenneri"},"merged_into":null,"legacy_description":null,"taxonomy":{"species":"brenneri","genus":"Caenorhabditis","id":"c_brenneri"},"page_type":"gene","dead":false,"name":{"label":"Cbn-srx-136","taxonomy":"c_brenneri","other_names":["CBN13762","CBN13762","CBN13762","CBN13762.1","CN14351"],"id":"WBGene00152487","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"class":"gene"}},{"legacy_description":null,"name":{"class":"gene","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"id":"WBGene00053532","other_names":["CRE06313","cr01.sctg2.wum.316","CRE06313","CRE06313.1","RP25422"],"taxonomy":"c_remanei","label":"Cre-srx-111.2"},"page_type":"gene","dead":false,"taxonomy":{"species":"remanei","genus":"Caenorhabditis","id":"c_remanei"},"allele":null,"merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"label":"Cre-srx-111.2","wbid":"WBGene00053532","other_names":["CRE06313","cr01.sctg2.wum.316","CRE06313","CRE06313.1","RP25422"],"description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-111."},{"other_names":["CRE05643","cr01.sctg1.wum.763","CRE05643.1","RP20504","CRE05643"],"description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-134.","wbid":"WBGene00052898","label":"Cre-srx-134","species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"merged_into":null,"allele":null,"taxonomy":{"id":"c_remanei","genus":"Caenorhabditis","species":"remanei"},"name":{"class":"gene","id":"WBGene00052898","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"label":"Cre-srx-134","taxonomy":"c_remanei","other_names":["CRE05643","cr01.sctg1.wum.763","CRE05643.1","RP20504","CRE05643"]},"page_type":"gene","dead":false,"legacy_description":null},{"legacy_description":null,"name":{"label":"Cre-srx-78","other_names":["CRE18209","cr01.sctg185.wum.3","RP47501","CRE18209","CRE18209.1"],"taxonomy":"c_remanei","id":"WBGene00070388","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"id":"c_remanei","genus":"Caenorhabditis","species":"remanei"},"allele":null,"label":"Cre-srx-78","wbid":"WBGene00070388","other_names":["CRE18209","cr01.sctg185.wum.3","RP47501","CRE18209","CRE18209.1"],"description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-78.","merged_into":null,"species":{"name":"Caenorhabditis remanei","key":"c_remanei"}},{"allele":null,"label":"Cre-srx-82","description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-82.","other_names":["CRE26986","cr01.sctg1.wum.194","CRE26986.1","RP31336","CRE26986"],"wbid":"WBGene00052313","merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"legacy_description":null,"name":{"class":"gene","label":"Cre-srx-82","taxonomy":"c_remanei","other_names":["CRE26986","cr01.sctg1.wum.194","CRE26986.1","RP31336","CRE26986"],"id":"WBGene00052313","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]}},"page_type":"gene","dead":false,"taxonomy":{"species":"remanei","genus":"Caenorhabditis","id":"c_remanei"}},{"allele":null,"description":"Is predicted to encode a protein with the following domains: Serpentine type 7TM GPCR chemoreceptor Srx and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-29; srx-31; and srx-32.","other_names":["CRE09634","cr01.sctg15.wum.184","CRE09634.1","RP34948","CRE09634"],"wbid":"WBGene00059738","label":"CRE09634","species":{"name":"Caenorhabditis remanei","key":"c_remanei"},"merged_into":null,"legacy_description":null,"taxonomy":{"species":"remanei","genus":"Caenorhabditis","id":"c_remanei"},"page_type":"gene","name":{"class":"gene","highlight":{"description_all":["Is an ortholog of C. elegans srx-29; srx-31; and srx-32."]},"id":"WBGene00059738","taxonomy":"c_remanei","other_names":["CRE09634","cr01.sctg15.wum.184","CRE09634.1","RP34948","CRE09634"],"label":"CRE09634"},"dead":false},{"allele":null,"label":"Bean1","other_names":[null],"wbid":"RGD:1562003","description":"Predicted to be located in membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 31. Orthologous to human BEAN1 (brain expressed associated with NEDD4 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; C60 fullerene; copper atom.","merged_into":null,"species":{"key":"r_norvegicus","name":"Rattus norvegicus"},"legacy_description":null,"dead":false,"page_type":"gene","name":{"class":"gene","id":"RGD:1562003","highlight":{"description_all":["Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 31."]},"label":"Bean1","other_names":[null],"taxonomy":"r_norvegicus"},"taxonomy":{"id":"r_norvegicus","genus":"Rattus","species":"norvegicus"}},{"taxonomy":{"id":"p_pacificus","genus":"Pristionchus","species":"pacificus"},"dead":false,"page_type":"gene","name":{"label":"PPA15468","taxonomy":"p_pacificus","other_names":["PPA15468","GENEPREDICTION_SNAP300000072218","UMM-S2840-22.17","PP19359","PPA15468.1","PPA15468"],"id":"WBGene00105022","highlight":{"description_all":["Is an ortholog of C. elegans C30G12.2; dhs-12; and dhs-31."]},"class":"gene"},"legacy_description":null,"species":{"key":"p_pacificus","name":"Pristionchus pacificus"},"merged_into":null,"other_names":["PPA15468","GENEPREDICTION_SNAP300000072218","UMM-S2840-22.17","PP19359","PPA15468.1","PPA15468"],"wbid":"WBGene00105022","description":"Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; NAD(P)-binding domain superfamily; and short chain dehydrogenase. Is an ortholog of C. elegans C30G12.2; dhs-12; and dhs-31.","label":"PPA15468","allele":null},{"legacy_description":null,"dead":false,"page_type":"gene","name":{"label":"PPA36790","other_names":["PPA36790","PPA36790.1","PPA36790","PP59361"],"taxonomy":"p_pacificus","id":"WBGene00275159","highlight":{"description_all":["Is an ortholog of C. elegans srg-36; srg-34; and srg-31."]},"class":"gene"},"taxonomy":{"species":"pacificus","genus":"Pristionchus","id":"p_pacificus"},"allele":null,"merged_into":null,"species":{"key":"p_pacificus","name":"Pristionchus pacificus"},"label":"PPA36790","other_names":["PPA36790","PPA36790.1","PPA36790","PP59361"],"wbid":"WBGene00275159","description":"Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in membrane. Is an ortholog of C. elegans srg-36; srg-34; and srg-31."},{"species":{"name":"Caenorhabditis brenneri","key":"c_brenneri"},"merged_into":null,"wbid":"WBGene00163096","other_names":["CBN24371","CBN24371","CBN24371","CBN24371.1","CN03809"],"description":"Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine type 7TM GPCR chemoreceptor Srx; and 7TM GPCR, serpentine receptor class x (Srx). Is an ortholog of C. elegans srx-115.","label":"Cbn-srx-115","allele":null,"taxonomy":{"id":"c_brenneri","genus":"Caenorhabditis","species":"brenneri"},"page_type":"gene","dead":false,"name":{"label":"Cbn-srx-115","taxonomy":"c_brenneri","other_names":["CBN24371","CBN24371","CBN24371","CBN24371.1","CN03809"],"id":"WBGene00163096","highlight":{"description_all":["Is predicted to encode a protein with the following domains: Serpentine receptor class gamma-31; Serpentine"]},"class":"gene"},"legacy_description":null}]}