gba-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Human ortholog(s) of this gene implicated in several diseases, including Gaucher's disease (multiple); Lewy body dementia; and Netherton syndrome. Is an ortholog of human GBA1 (glucosylceramidase beta 1).
glb-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables heme binding activity; iron ion binding activity; and oxygen binding activity. Predicted to be involved in oxygen transport and response to hypoxia. Expressed in neurons and somatic nervous system.
Y57G11C.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in nucleus. Expressed in germ cell. Is an ortholog of human PGLS (6-phosphogluconolactonase).
cps-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Is an ortholog of human ENDOG (endonuclease G).
pfkb-1.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
pfkb-1.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
PPA12013 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: Amino acid transporter, transmembrane domain and Transmembrane amino acid transporter protein. Is an ortholog of C. elegans Y18D10A.23 and Y4C6B.2.
sas-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity and protein domain specific binding activity. Involved in centriole replication; protein localization; and regulation of cell cycle. Located in centriole and cytoplasm.
pfd-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in cytoplasm. Expressed in body wall musculature; hypodermal cell; intestinal cell; and non-striated muscle. Is an ortholog of human PFDN6 (prefoldin subunit 6).
pbo-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables extracellular ligand-gated monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in body wall musculature.
mua-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cytoskeleton. Involved in cell-cell adhesion. Located in hemidesmosome. Expressed in hypodermis; touch receptor neurons; uterus; and ventral cord neurons. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2).
gfat-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Is an ortholog of human GFPT1 (glutamine--fructose-6-phosphate transaminase 1).
coq-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Is an ortholog of human COQ6 (coenzyme Q6, monooxygenase).
pph-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine phosphatase activity. Involved in cortical actin cytoskeleton organization; establishment of mitotic spindle localization; and first cell cycle pseudocleavage. Located in astral microtubule and cell cortex. Is an ortholog of human PPP6C (protein phosphatase 6 catalytic subunit).
set-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone H3K9 dimethyltransferase activity and histone H3K9 trimethyltransferase activity. Involved in epigenetic regulation of gene expression. Part of chromatin. Expressed in embryonic cell; gonad; muscle cell; nervous system; and sperm. Is an ortholog of human SUV39H2 (SUV39H2 histone lysine methyltransferase).
sul-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in Golgi stack; cell surface; and endoplasmic reticulum. Is an ortholog of human SULF1 (sulfatase 1) and SULF2 (sulfatase 2).
tba-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule. Expressed in HSN; ciliated neurons; intestine; and vulva.
rgs-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Human ortholog(s) of this gene implicated in nephrolithiasis. Is an ortholog of human RGS14 (regulator of G protein signaling 14).
haf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in perinuclear endoplasmic reticulum. Expressed in germ line; intestine; and muscle cell. Is an ortholog of human ABCB8 (ATP binding cassette subfamily B member 8).
ncx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be located in membrane. Expressed in ADLL and ADLR. Is an ortholog of human SLC8B1 (solute carrier family 8 member B1).
atf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in nucleus. Expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Is an ortholog of human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta).
catp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Involved in protein folding. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including egg-laying apparatus; gonad; oocyte; pharynx; and somatic gonad precursor. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is an ortholog of human ATP13A3 (ATPase 13A3).
arl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity. Involved in intracellular transport. Located in axoneme; cytosol; and dendrite. Expressed in ciliated neurons. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Is an ortholog of human ARL6 (ADP ribosylation factor like GTPase 6).
cogc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIl. Is an ortholog of human COG6 (component of oligomeric golgi complex 6).
ddx-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Is an ortholog of human DDX10 (DEAD-box helicase 10).
par-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase C binding activity and small GTPase binding activity. Involved in several processes, including establishment of mitotic spindle localization; gonad development; and polarity specification of anterior/posterior axis. Located in P granule and cell cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Expressed in several structures, including ABa; EMS; Psub2; Psub3; and excretory cell. Is an ortholog of human PARD6B (
par-6 family cell polarity regulator beta).
hst-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and regulation of growth. Predicted to be located in membrane. Expressed in AIBL; AIBR; RIML; RIMR; and neurons. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Is an ortholog of human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1).
cah-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in cytoplasm. Expressed in head neurons; nervous system; and tail neurons. Is an ortholog of human CA6 (carbonic anhydrase 6).
inx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in gap junction and plasma membrane. Expressed in head neurons; pharyngeal cell; and rectal valve cell.
lsy-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in determination of left/right asymmetry in nervous system and miRNA-mediated post-transcriptional gene silencing. Expressed in ASEL; head neurons; and tail neurons.
aex-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity and GTPase activity. Involved in exocytosis; positive regulation of defecation; and positive regulation of protein catabolic process. Located in synaptic vesicle. Expressed in ALML; ALMR; BDUL; BDUR; and neurons. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Is an ortholog of human RAB27A (RAB27A, member RAS oncogene family).
egl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled peptide receptor activity. Involved in negative regulation of egg-laying behavior. Predicted to be located in plasma membrane. Expressed in GLR; nerve ring; and neurons.
gspd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucose-6-phosphate dehydrogenase activity. Predicted to be involved in glucose metabolic process and pentose-phosphate shunt, oxidative branch. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; diabetes mellitus (multiple); and favism. Is an ortholog of human G6PD (glucose-6-phosphate dehydrogenase).
hsp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in mitochondrial unfolded protein response. Located in mitochondrion. Expressed in muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; autosomal dominant sideroblastic anemia 4; and rheumatoid arthritis. Is an ortholog of human HSPA9 (heat shock protein family A (Hsp70) member 9).
ptps-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 6-pyruvoyltetrahydropterin synthase activity and identical protein binding activity. Involved in tetrahydrobiopterin biosynthetic process. Predicted to be located in mitochondrion. Expressed in hypodermis and neurons. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Is an ortholog of human PTS (6-pyruvoyltetrahydropterin synthase).
T03F6.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in N-acetylglucosamine catabolic process; N-acetylneuraminate catabolic process; and glucosamine catabolic process. Predicted to be located in cytoplasm. Expressed in tail. Is an ortholog of human GNPDA1 (glucosamine-6-phosphate deaminase 1).
acl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in cellular lipid metabolic process and glycerol-3-phosphate metabolic process. Located in mitochondrion. Expressed in muscle cell. Is an ortholog of human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial).
eif-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ribosomal large subunit binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytosol and nucleolus. Predicted to be part of preribosome, large subunit precursor. Used to study obesity. Is an ortholog of human EIF6 (eukaryotic translation initiation factor 6).
mig-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development. Located in basement membrane. Expressed in several structures, including CAN; GLR; basal lamina; enteric muscle; and somatic gonad precursor. Is an ortholog of human PAPLN (papilin, proteoglycan like sulfated glycoprotein).
rme-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables small GTPase binding activity. Involved in endocytosis; molting cycle; and regulation of clathrin-dependent endocytosis. Located in clathrin-coated endocytic vesicle; early endosome; and plasma membrane. Expressed in several structures, including anterior gonad arm; coelomocyte; intestine; oocyte; and pharynx. Is an ortholog of human GAPVD1 (GTPase activating protein and VPS9 domains 1).
cct-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. Is an ortholog of human CCT6B (chaperonin containing TCP1 subunit 6B).
lpd-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable rRNA binding activity. Involved in lipid storage. Predicted to be located in membrane. Predicted to be part of preribosome, large subunit precursor. Is an ortholog of human PPAN (peter pan homolog) and PPAN-P2RY11 (PPAN-P2RY11 readthrough).
otpl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Is an ortholog of human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3).
csn-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metallopeptidase activity. Predicted to be involved in oogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Is an ortholog of human COPS6 (COP9 signalosome subunit 6).
osm-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including non-motile cilium assembly; response to osmotic stress; and sensory perception of mechanical stimulus. Located in cilium; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Is an ortholog of human IFT52 (intraflagellar transport 52).
gpi-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol. Expressed in head. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including congenital nonspherocytic hemolytic anemia; leukemia (multiple); and neuromuscular disease. Is an ortholog of human GPI (glucose-6-phosphate isomerase).
pfk-1.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including 6-phosphofructokinase activity; carbohydrate derivative binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is an ortholog of human PFKL (phosphofructokinase, liver type); PFKM (phosphofructokinase, muscle); and PFKP (phosphofructokinase, platelet).
him-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3'-5' DNA helicase activity and enzyme binding activity. Involved in several processes, including determination of adult lifespan; meiotic nuclear division; and resolution of recombination intermediates. Located in chromosome and nucleus. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Is an ortholog of human BLM (BLM RecQ like helicase).
nol-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Involved in negative regulation of innate immune response. Predicted to be located in condensed nuclear chromosome and nucleolus. Predicted to be part of CURI complex; UTP-C complex; and small-subunit processome. Is an ortholog of human NOL6 (nucleolar protein 6).
dyf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Expressed in ciliated neurons and hypodermis. Is an ortholog of human IFT46 (intraflagellar transport 46).
snf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables PDZ domain binding activity and acetylcholine transmembrane transporter activity. Involved in acetylcholine transport; choline transport; and positive regulation of locomotion. Predicted to be located in postsynaptic membrane. Expressed in body wall musculature; enteric muscle; neurons; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Is an ortholog of human SLC6A14 (solute carrier family 6 member 14) and SLC6A5 (solute carrier family 6 member 5).
ccr-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Part of CCR4-NOT complex. Expressed in body wall musculature; germ line; neurons; somatic cell; and in male. Is an ortholog of human CNOT6 (CCR4-NOT transcription complex subunit 6) and CNOT6L (CCR4-NOT transcription complex subunit 6 like).
twk-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Expressed in hypodermis and tail. Is an ortholog of several human genes including KCNK2 (potassium two pore domain channel subfamily K member 2); KCNK4 (potassium two pore domain channel subfamily K member 4); and KCNK5 (potassium two pore domain channel subfamily K member 5).
arf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ADP ribosylation factor 6).
hcp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore; embryo development; and mitotic chromosome condensation. Located in condensed chromosome, centromeric region and nucleoplasm. Part of condensin complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human NCAPD3 (non-SMC condensin II complex subunit D3).
pfk-1.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including 6-phosphofructokinase activity; carbohydrate derivative binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Expressed in germ line; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is an ortholog of human PFKL (phosphofructokinase, liver type) and PFKM (phosphofructokinase, muscle).
efa-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular component disassembly; regulation of cellular component organization; and regulation of mitotic centrosome separation. Located in cell cortex; microtubule minus-end; and plasma membrane. Expressed in U.la; U.lp; and linker cell. Is an ortholog of human PSD (pleckstrin and Sec7 domain containing).
elt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate commitment; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpaapap; ABarpaappa; ABarpaappp; ABprpppppaa; and body wall muscle cell from MS lineage.
ubc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be located in nucleus. Expressed in germ line and oocyte. Is an ortholog of human UBE2J1 (ubiquitin conjugating enzyme E2 J1).
daf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of dauer larval development; and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including cuticle; excretory system; interfacial epithelial cell; neurons; and vulval cell. Is an ortholog of human PTCHD3 (patched domain containing 3 (gene/pseudogene)).
F47B8.10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucose 6-phosphate:inorganic phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Is an ortholog of human SLC37A4 (solute carrier family 37 member 4).
fkb-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Hsp90 protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in cytoplasm. Expressed in dorsal nerve cord; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in major depressive disorder. Is an ortholog of human FKBP4 (FKBP prolyl isomerase 4) and FKBP5 (FKBP prolyl isomerase 5).
mdt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is an ortholog of human MED6 (mediator complex subunit 6).
rps-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Involved in determination of adult lifespan. Predicted to be located in cytoplasm; nucleolus; and ribosome. Predicted to be part of small-subunit processome. Is an ortholog of human RPS6 (ribosomal protein S6).
mboa-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in glycerophospholipid biosynthetic process; positive regulation of growth rate; and post-embryonic development. Predicted to be located in endoplasmic reticulum and membrane. Expressed in pharyngeal muscle cell and tail. Is an ortholog of human LPCAT3 (lysophosphatidylcholine acyltransferase 3).
rig-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including axon guidance; negative regulation of defecation rhythm; and regulation of locomotion. Located in axon; neuronal cell body; and synapse. Expressed in several structures, including body wall musculature; neurons; non-striated muscle; rectal epithelium; and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including Compton-North congenital myopathy; familial adult myoclonic epilepsy 5; and high grade glioma. Is an ortholog of human CNTN6 (contactin 6).
acr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Human ortholog(s) of this gene implicated in lung disease (multiple); nicotine dependence; and stomach cancer. Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
cdc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitotic DNA replication checkpoint signaling. Located in condensed nuclear chromosome; cytoplasm; and nucleolus. Expressed in seam cell. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Is an ortholog of human CDC6 (cell division cycle 6).
ser-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables octopamine receptor activity. Involved in positive regulation of fatty acid beta-oxidation by octopamine signaling pathway. Predicted to be located in dendrite. Expressed in intestine; neurons; and in male.
gfat-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in IRE1-mediated unfolded protein response. Expressed in tail. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Is an ortholog of human GFPT1 (glutamine--fructose-6-phosphate transaminase 1).
rsp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity. Involved in gonad development and regulation of termination of DNA-templated transcription. Located in nucleus. Expressed in several structures, including PVDL and PVDR. Human ortholog(s) of this gene implicated in bipolar disorder; clear cell renal cell carcinoma; and ovary epithelial cancer. Is an ortholog of human SRSF7 (serine and arginine rich splicing factor 7).
acp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in membrane. Is an ortholog of human ACP6 (acid phosphatase 6, lysophosphatidic).
acp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in membrane. Is an ortholog of human ACP6 (acid phosphatase 6, lysophosphatidic).
acp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in membrane. Is an ortholog of human ACP6 (acid phosphatase 6, lysophosphatidic).
ceh-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in transdifferentiation. Acts upstream of with a positive effect on multicellular organismal-level water homeostasis. Located in cytosol and nucleus. Expressed in body wall musculature;
hyp7 syncytium; intestine; and neurons. Human ortholog(s) of this gene implicated in X-linked deafness 2. Is an ortholog of human POU3F1 (POU class 3 homeobox 1); POU3F3 (POU class 3 homeobox 3); and POU3F4 (POU class 3 homeobox 4).
pgp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in plasma membrane. Expressed in amphid neurons and head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4).
F59B2.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process. Is an ortholog of human AMDHD2 (amidohydrolase domain containing 2).
elo-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fatty acid elongase activity. Involved in methyl-branched fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in amphid neurons; intestine; nerve ring; and vulva.
hrg-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in heme transport. Predicted to be located in lysosomal membrane and plasma membrane.
C42C1.19 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucose 6-phosphate:inorganic phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Is an ortholog of human SLC37A4 (solute carrier family 37 member 4).
D1081.19 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Is affected by several genes including
isp-1;
unc-30; and
nuo-6 based on RNA-seq and microarray studies. Is affected by six chemicals including Atrazine; cadmium; and fluoranthene based on microarray studies. Is predicted to encode a protein with the following domains: Nematode trypsin-6-like family; Peptidase S1, PA clan; Chymotrypsin family Peptidase-S1; and Peptidase S1, PA clan, chymotrypsin-like fold.
msh-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable four-way junction DNA binding activity and mismatched DNA binding activity. Involved in maintenance of DNA repeat elements and mismatch repair. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in several diseases, including colorectal carcinoma; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Is an ortholog of human MSH6 (mutS homolog 6).
vha-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit
a1); ATP6V0A2 (ATPase H+ transporting V0 subunit
a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit
a3).
mes-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to contribute to nucleosome binding activity. Involved in regulation of gene expression. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; intestinal cell; and oocyte. Is an ortholog of human EED (embryonic ectoderm development).
acp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Expressed in ALML; ALMR; PLML; PLMR; and spermatheca. Is an ortholog of human ACP6 (acid phosphatase 6, lysophosphatidic).
prdx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peroxiredoxin activity. Predicted to be involved in cell redox homeostasis. Predicted to be located in cytosol and mitochondrion. Is an ortholog of human PRDX6 (peroxiredoxin 6).
nhr-80 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in determination of adult lifespan; positive regulation of metabolic process; and post-embryonic development. Located in nucleus. Expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons.
xpo-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in cytoplasm and nuclear matrix. Predicted to be part of nuclear pore. Is an ortholog of human XPOT (exportin for tRNA).
srb-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane signaling receptor activity. Involved in defense response to Gram-positive bacterium and detection of chemical stimulus. Located in cilium. Expressed in chemosensory neurons; head; tail; and
uv1.
fut-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables galactoside 6-L-fucosyltransferase activity and glycoprotein 6-alpha-L-fucosyltransferase activity. Involved in fucosylation and protein N-linked glycosylation. Predicted to be located in Golgi cisterna membrane. Is an ortholog of human FUT8 (fucosyltransferase 8).
dop-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; and dopamine receptor signaling pathway. Predicted to be located in dendrite. Expressed in several structures, including AVF; SMDVL; head neurons; intestine; and lumbar neurons.
skr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human SKP1 (S-phase kinase associated protein 1).
sma-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables BMP binding activity. Involved in several processes, including defense response to other organism; nematode male tail tip morphogenesis; and positive regulation of nitrogen compound metabolic process. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in ASI; hypodermis; intestinal cell; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including bone development disease (multiple); carcinoma (multiple); and glaucoma (multiple). Is an ortholog of human BMPR1B (bone morphogenetic protein receptor type 1B).
unc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable signaling receptor binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis. Located in axon; basement membrane; and cytoplasm. Expressed in several structures, including P1; VA12; accessory cell; interneuron; and somatic neurons. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Is an ortholog of human NTN1 (netrin 1).
wrt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in anterior ganglion (ant); hypodermis; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule).
arp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable nucleosome binding activity. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Swr1 complex. Is an ortholog of human ACTR6 (actin related protein 6).
pas-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome core complex, alpha-subunit complex. Is an ortholog of human PSMA1 (proteasome 20S subunit alpha 1).
fat-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables stearoyl-CoA 9-desaturase activity. Involved in innate immune response; long-chain fatty acid biosynthetic process; and post-embryonic development. Predicted to be located in endoplasmic reticulum membrane. Expressed in hypodermis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Is an ortholog of human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5).
orc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Is an ortholog of human ORC1 (origin recognition complex subunit 1).
epg-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Expressed widely. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Is an ortholog of human WDR45 (WD repeat domain 45).
pde-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of oocyte maturation. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Is an ortholog of human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B).
nhr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of ovulation; and spermathecum morphogenesis. Located in nucleus. Expressed in BAGL; BAGR; chemosensory neurons; head neurons; and spermatheca. Human ortholog(s) of this gene implicated in Parkinson's disease and extraskeletal myxoid chondrosarcoma. Is an ortholog of human NR4A2 (nuclear receptor subfamily 4 group A member 2) and NR4A3 (nuclear receptor subfamily 4 group A member 3).
T03F6.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be located in membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Is an ortholog of human REEP5 (receptor accessory protein 5) and REEP6 (receptor accessory protein 6).
F56B3.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be located in membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Is an ortholog of human REEP5 (receptor accessory protein 5) and REEP6 (receptor accessory protein 6).
fut-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Is an ortholog of human FUT5 (fucosyltransferase 5) and FUT6 (fucosyltransferase 6).
hxk-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in carbohydrate metabolic process; glucose 6-phosphate metabolic process; and intracellular glucose homeostasis. Predicted to be located in cytosol and mitochondrion.
gly-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in Golgi apparatus. Is an ortholog of human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6).
emc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is an ortholog of human EMC6 (ER membrane protein complex subunit 6).
mstr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and zinc ion binding activity. Located in nucleus. Is an ortholog of human ZFAND5 (zinc finger AN1-type containing 5) and ZFAND6 (zinc finger AN1-type containing 6).
trmt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in tRNA methylation. Predicted to be located in nucleus. Predicted to be part of tRNA (
m1A) methyltransferase complex. Is an ortholog of human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit).
sulp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); and bone disease (multiple). Is an ortholog of several human genes including SLC26A2 (solute carrier family 26 member 2); SLC26A3 (solute carrier family 26 member 3); and SLC26A4 (solute carrier family 26 member 4).
ced-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables clathrin adaptor activity and scavenger receptor binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in cytoplasmic side of plasma membrane and phagocytic vesicle. Is an ortholog of human GULP1 (GULP PTB domain containing engulfment adaptor 1).
cup-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in lysosome organization. Predicted to be located in endosome. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6. Is an ortholog of human PLEKHM1 (pleckstrin homology and RUN domain containing M1).
snf-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
snf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
Y39A1C.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Located in striated muscle dense body. Expressed in nerve ring. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Is an ortholog of human TMIE (transmembrane inner ear).
mtp-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in mitochondrial fission. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Parkinson's disease 6 and neuroblastoma. Is an ortholog of human MTFP1 (mitochondrial fission process 1).
snf-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
sur-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta).
ram-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Involved in nematode male tail tip morphogenesis and sensory organ development. Predicted to be located in membrane. Predicted to be part of collagen trimer.
spp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in ALM; PLM; body wall muscle cell; and intestine based on tiling array; microarray; and RNA-seq studies. Is affected by several genes including
skn-1;
daf-12; and
elt-2 based on microarray; tiling array; and RNA-seq studies. Is affected by eleven chemicals including methylmercuric chloride; stavudine; and Psoralens based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Saposin B type, region 2; Saposin B type domain; Saposin-like type B, region 2; and Saposin-like.
exos-4.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in RNA metabolic process. Predicted to be located in nucleolus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is an ortholog of human EXOSC6 (exosome component 6).
yop-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Located in cortical endoplasmic reticulum. Expressed in head and tail. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Is an ortholog of human REEP5 (receptor accessory protein 5) and REEP6 (receptor accessory protein 6).
gly-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calmodulin binding activity and hexosyltransferase activity. Involved in protein N-linked glycosylation. Located in nucleus. Expressed in hermaphrodite gonad; neurons; pharyngeal-intestinal valve;
pm8; and somatic nervous system. Is an ortholog of human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) and MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B).
tat-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endosome; plasma membrane; and trans-Golgi network. Expressed in anterior spermathecal-uterine core cell; gonad; head; and tail. Is an ortholog of human ATP9B (ATPase phospholipid transporting 9B (putative)).
fkh-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in male germ-line sex determination and male gonad development. Predicted to be located in nucleus. Expressed in gonadal sheath cell; male gonad; somatic gonad precursor; spermatheca; and in male. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Is an ortholog of human FOXI2 (forkhead box I2) and FOXI3 (forkhead box I3).
rbpl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Expressed in intestine; neurons; spermatheca; and vulva. Is an ortholog of human RBBP6 (RB binding protein 6, ubiquitin ligase).
Y39E4B.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 7SK snRNA binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm.
glr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane.
gldi-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis and ribosomal small subunit biogenesis. Predicted to be located in nucleolus. Is an ortholog of human SURF6 (surfeit 6).
mcm-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to be located in nucleus. Predicted to be part of MCM complex. Is an ortholog of human MCM6 (minichromosome maintenance complex component 6).
Y49E10.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-disulfide reductase activity. Predicted to be involved in response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Is an ortholog of human PDIA6 (protein disulfide isomerase family A member 6).
PMI40 [Search on AGR]
Saccharomyces cerevisiae Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
puf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA 3'-UTR binding activity. Involved in germ cell development and negative regulation of cell population proliferation. Predicted to be located in cytoplasm and nucleus.
C01G10.10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in mitochondrion. Is an ortholog of human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1).
T13C5.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sphingosine-1-phosphate phosphatase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in membrane. Is an ortholog of human PLPP6 (phospholipid phosphatase 6) and PLPP7 (phospholipid phosphatase 7 (inactive)).
B0334.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in biosynthetic process. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 5 and nuclear type mitochondrial complex I deficiency 17. Is an ortholog of human NDUFAF6 (NADH:ubiquinone oxidoreductase complex assembly factor 6).
dhhc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Is an ortholog of human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6).
uda-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GDP phosphatase activity and UDP phosphatase activity. Involved in GDP metabolic process and UDP metabolic process. Located in cytoplasmic vesicle membrane. Is an ortholog of human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)) and ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6).
mppb-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Contributes to metalloendopeptidase activity. Involved in proteolysis. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple mitochondrial dysfunctions syndrome 6. Is an ortholog of human PMPCB (peptidase, mitochondrial processing subunit beta).
saps-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein phosphatase binding activity. Involved in cortical actin cytoskeleton organization; establishment of mitotic spindle localization; and first cell cycle pseudocleavage. Located in astral microtubule and cell cortex. Is an ortholog of human PPP6R3 (protein phosphatase 6 regulatory subunit 3).
snx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein self-association. Involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in early phagosome. Is an ortholog of human SNX32 (sorting nexin 32); SNX5 (sorting nexin 5); and SNX6 (sorting nexin 6).
swsn-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6 and gastrointestinal system cancer (multiple). Is an ortholog of human ARID2 (AT-rich interaction domain 2).
snr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypotrichosis (multiple); and lupus nephritis. Is an ortholog of human SNRPE (small nuclear ribonucleoprotein polypeptide E).
mex-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule. Expressed in AB; ABa; ABp; and germ line.
agl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Is an ortholog of human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase).
Y50E8A.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to be located in mitochondrion. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human GPD2 (glycerol-3-phosphate dehydrogenase 2).
F46B6.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity and metal ion binding activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be located in mitochondrion. Is an ortholog of human GTPBP6 (GTP binding protein 6 (putative)).
ipla-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-independent phospholipase A2 activity. Predicted to be involved in arachidonic acid metabolic process. Predicted to be located in membrane. Is an ortholog of human PNPLA8 (patatin like phospholipase domain containing 8).
K05C4.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in endoplasmic reticulum organization and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 6. Is an ortholog of human JAGN1 (jagunal homolog 1).
ubc-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cysteine-type endopeptidase inhibitor activity and ubiquitin conjugating enzyme activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be located in nucleus. Is an ortholog of human BIRC6 (baculoviral IAP repeat containing 6).
sqv-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein xylosyltransferase activity. Involved in several processes, including UDP-D-xylose metabolic process; egg-laying behavior; and glycosaminoglycan biosynthetic process. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Desbuquois dysplasia; pseudoxanthoma elasticum; and type 1 diabetes mellitus. Is an ortholog of human XYLT1 (xylosyltransferase 1).
abf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in posterior arcade cell based on single-cell RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
eat-2 based on RNA-seq and microarray studies. Is affected by twelve chemicals including rotenone; multi-walled carbon nanotube; and Cry5B based on RNA-seq and microarray studies.
F08G12.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity. Predicted to be located in cytosol and nucleus. Expressed in head muscle; hermaphrodite distal tip cell; neurons; and pharyngeal muscle cell. Is an ortholog of human RABL6 (RAB, member RAS oncogene family like 6).
mtm-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatase binding activity. Involved in several processes, including nematode larval development; phosphatidylinositol metabolic process; and pinocytosis. Located in apical plasma membrane and cytosol. Expressed in several structures, including anal depressor muscle; coelomocyte; intestinal cell; preanal ganglion; and tail. Used to study centronuclear myopathy. Is an ortholog of human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8).
smc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Located in condensed nuclear chromosome and nucleoplasm. Is an ortholog of human SMC6 (structural maintenance of chromosomes 6).
zhit-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Located in nucleus. Is an ortholog of human ZNHIT6 (zinc finger HIT-type containing 6).
sftb-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U2 snRNP and spliceosomal complex. Is an ortholog of human SF3B6 (splicing factor 3b subunit 6).
Coro6 [Search on AGR]
Rattus norvegicus Orthologous to human CORO6 (coronin 6); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
eat-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3).
gob-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables trehalose-phosphatase activity. Involved in carbohydrate derivative catabolic process; dephosphorylation; and trehalose biosynthetic process. Located in cytoplasm. Expressed in several structures, including body wall musculature; head neurons; intestine; pharynx; and tail.
pac-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activator activity. Involved in Rho protein signal transduction; protein localization; and regulation of gastrulation. Located in cell junction. Expressed in anus; epithelial cell; hypodermis; pharynx; and
pm7. Is an ortholog of human ARHGAP23 (Rho GTPase activating protein 23).
clp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3).
C05C8.7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ib. Is an ortholog of human MPI (mannose phosphate isomerase).
pdi-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-disulfide reductase activity. Involved in negative regulation of IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen. Expressed in head; intestinal muscle; and tail. Is an ortholog of human PDIA6 (protein disulfide isomerase family A member 6).
scav-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable scavenger receptor activity. Predicted to be involved in endocytosis. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human SCARB1 (scavenger receptor class B member 1).
rpt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Is an ortholog of human PSMC5 (proteasome 26S subunit, ATPase 5).
bli-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in membrane. Predicted to be part of collagen trimer.
Ppil6 [Search on AGR]
Rattus norvegicus Orthologous to human PPIL6 (peptidylprolyl isomerase like 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
F39B2.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be part of phosphatidylinositol 3-kinase complex. Is an ortholog of human SOCS6 (suppressor of cytokine signaling 6) and SOCS7 (suppressor of cytokine signaling 7).
C17h6orf52 [Search on AGR]
Rattus norvegicus Orthologous to human C6orf52 (chromosome 6 open reading frame 52); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; endosulfan.
Ctsql2 [Search on AGR]
Rattus norvegicus Predicted to be involved in apoptotic process; INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; bisphenol A.
nhx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A2 (solute carrier family 9 member A2); SLC9A3 (solute carrier family 9 member A3); and SLC9A5 (solute carrier family 9 member A5).
mtq-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and protein methyltransferase activity. Predicted to be involved in methylation; nitrogen compound metabolic process; and primary metabolic process. Predicted to be part of eRF1 methyltransferase complex. Is an ortholog of human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1).
prx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP hydrolysis activity. Involved in nematode larval development. Predicted to be located in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 2 and peroxisome biogenesis disorder 4A. Is an ortholog of human PEX6 (peroxisomal biogenesis factor 6).
vps-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be located in multivesicular body. Predicted to be part of ESCRT III complex. Is an ortholog of human CHMP6 (charged multivesicular body protein 6).
Y65B4A.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Is an ortholog of human COASY (Coenzyme A synthase).
C12orf60 [Search on AGR]
Homo sapiens ASSOCIATED WITH autosomal dominant intellectual developmental disorder 6; congenital diarrhea 6; genetic disease; INTERACTS WITH 2-palmitoylglycerol; acrylamide; aflatoxin B1
C5h6orf163 [Search on AGR]
Rattus norvegicus Orthologous to human C6orf163 (chromosome 6 open reading frame 163); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.
Btbd16 [Search on AGR]
Rattus norvegicus Orthologous to human BTBD16 (BTB domain containing 16); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.
C10G11.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in germ line and germline precursor cell based on RNA-seq studies. Is affected by several genes including
hsf-1;
pgl-1; and
hsp-6 based on microarray and RNA-seq studies. Is affected by eight chemicals including rotenone; Aspirin; and Alovudine based on RNA-seq studies.
mlc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B).
dao-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in several structures, including ABalppppaa; anterior arcade cell; excretory cell; head mesodermal cell; and pharyngeal cell based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
daf-12 based on microarray and RNA-seq studies. Is affected by twelve chemicals including Cadmium Chloride; Sodium Chloride; and Psoralens based on RNA-seq and microarray studies.
tyr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Human ortholog(s) of this gene implicated in oculocutaneous albinism type III and pigmentation disease. Is an ortholog of human DCT (dopachrome tautomerase).
prp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Is an ortholog of human PRPF6 (pre-mRNA processing factor 6).
snf-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in plasma membrane. Expressed in amphid neurons; intestinal cell; pharyngeal neurons; and rectal gland cell. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
C09D4.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in somatic gonad precursor and in male based on RNA-seq studies. Is affected by several genes including
daf-2;
eat-2; and
hsp-6 based on microarray and RNA-seq studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.
tag-77 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be located in cytoplasm. Expressed in hermaphrodite gonad and somatic gonad precursor. Is an ortholog of human FGD5 (FYVE, RhoGEF and PH domain containing 5) and FGD6 (FYVE, RhoGEF and PH domain containing 6).
odr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in olfactory behavior and response to odorant. Located in axon; external side of plasma membrane; and neuronal cell body. Expressed in head neurons; sensory neurons; somatic nervous system; tail; and in male.
snf-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Involved in positive regulation of amoeboid sperm motility. Located in cell body membrane. Expressed in germ line; secondary spermatocyte; sperm; spermatid; and spermatocyte. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
Xkr6 [Search on AGR]
Rattus norvegicus Predicted to be active in plasma membrane. Orthologous to human XKR6 (XK related 6); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
CBN05831 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
T18D3.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in cellular response to reactive oxygen species. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Is an ortholog of human MPV17 (mitochondrial inner membrane protein MPV17).
ptr-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in molting cycle. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Expressed in accessory cell. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4).
CBG02284 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
CBN11730 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
CRE11726 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
PPA28674 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
Bm7494 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
OVOC3488 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
SRAE_2000401400 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Is predicted to encode a protein with the following domains: Surfeit locus protein 6; Surfeit locus 6; and Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain. Is an ortholog of C. elegans ZK546.14.
Gnpda1 [Search on AGR]
Homo sapiens Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]
Tspan11 [Search on AGR]
Rattus norvegicus Predicted to be located in membrane. Orthologous to human TSPAN11 (tetraspanin 11); INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; acrylamide.
Cbr-sas-6 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is predicted to encode a protein with the following domains: Centriolar protein SAS N-terminal; SAS-6, N-terminal domain superfamily; and Spindle assembly abnormal protein 6, N-terminal. Is an ortholog of C. elegans
sas-6. In C. elegans,
sas-6 is involved in centriole replication; protein localization; and regulation of cell cycle.
Cjp-sas-6 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: Centriolar protein SAS N-terminal; SAS-6, N-terminal domain superfamily; and Spindle assembly abnormal protein 6, N-terminal. Is an ortholog of C. elegans
sas-6. In C. elegans,
sas-6 is involved in centriole replication; protein localization; and regulation of cell cycle.
Cre-sas-6.2 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Centriolar protein SAS N-terminal; SAS-6, N-terminal domain superfamily; and Spindle assembly abnormal protein 6, N-terminal. Is an ortholog of C. elegans
sas-6. In C. elegans,
sas-6 is involved in centriole replication; protein localization; and regulation of cell cycle.
Cre-sas-6.1 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Centriolar protein SAS N-terminal; SAS-6, N-terminal domain superfamily; and Spindle assembly abnormal protein 6, N-terminal. Is an ortholog of C. elegans
sas-6. In C. elegans,
sas-6 is involved in centriole replication; protein localization; and regulation of cell cycle.
Cbn-sas-6 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Centriolar protein SAS N-terminal; SAS-6, N-terminal domain superfamily; and Spindle assembly abnormal protein 6, N-terminal. Is an ortholog of C. elegans
sas-6. In C. elegans,
sas-6 is involved in centriole replication; protein localization; and regulation of cell cycle.
F07E5.13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Is affected by several genes including
pmk-1;
nuo-6; and
lipl-4 based on RNA-seq and microarray studies. Is affected by paraquat based on microarray studies. Is predicted to encode a protein with the following domains: F-box domain; F-box associated; and F-box associated domain, type 2.
pbs-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Expressed in pharynx. Is an ortholog of human PSMB1 (proteasome 20S subunit beta 1).
T16G1.18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in ABplppppaa; ABprppppaa; and neurons based on single-cell RNA-seq and RNA-seq studies. Is affected by several genes including
egl-43;
etr-1; and
set-6 based on RNA-seq studies. Is affected by four chemicals including Sirolimus; Rifampin; and allantoin based on RNA-seq and microarray studies.
marc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Is an ortholog of human MARCHF6 (membrane associated ring-CH-type finger 6).