cogc-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Is an ortholog of human COG4 (component of oligomeric golgi complex 4).
F53H1.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in recycling endosome. Is an ortholog of human DENND6A (DENN domain containing 6A) and DENND6B (DENN domain containing 6B).
C32D5.11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in protein import into peroxisome matrix. Predicted to be located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 6A. Is an ortholog of human PEX10 (peroxisomal biogenesis factor 10).
mtm-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatase binding activity. Involved in several processes, including nematode larval development; phosphatidylinositol metabolic process; and pinocytosis. Located in apical plasma membrane and cytosol. Expressed in several structures, including anal depressor muscle; coelomocyte; intestinal cell; preanal ganglion; and tail. Used to study centronuclear myopathy. Is an ortholog of human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8).
smp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Expressed in several structures, including hook; inner labial neurons; pharyngeal cell; ray; and vulval cell. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Is an ortholog of several human genes including SEMA6A (semaphorin 6A); SEMA6B (semaphorin 6B); and SEMA6C (semaphorin 6C).
Lce6a [Search on AGR]
Rattus norvegicus Orthologous to human LCE6A (late cornified envelope 6A); INTERACTS WITH 2-hydroxypropanoic acid (ortholog); aflatoxin B1 (ortholog); arsane (ortholog).
Otud6a [Search on AGR]
Rattus norvegicus Predicted to enable cysteine-type deubiquitinase activity. Orthologous to human OTUD6A (OTU deubiquitinase 6A); INTERACTS WITH Cuprizon; benzo[a]pyrene (ortholog); bisphenol A (ortholog).
Trappc6a [Search on AGR]
Rattus norvegicus Predicted to be located in endoplasmic reticulum. Orthologous to human TRAPPC6A (trafficking protein particle complex subunit 6A); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
PPA15491 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: Serpentine type 7TM GPCR chemoreceptor Srd and 7TM GPCR, serpentine receptor class d (Srd). Is an ortholog of C. elegans F28G4.2; Y51H7C.12; and F49C12.3.
PPA15573 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable ATP binding activity and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans F28G4.2; Y51H7C.12; and F49C12.3.
mtm-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatase binding activity. Involved in pinocytosis and regulation of cell migration. Located in cytosol and plasma membrane. Expressed in several structures, including CAN; PDE; coelomocyte; epithelial cell; and vulva. Used to study centronuclear myopathy. Is an ortholog of human MTMR9 (myotubularin related protein 9).
Dennd6a [Search on AGR]
Rattus norvegicus Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in recycling endosome. Orthologous to human DENND6A (DENN domain containing 6A); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole.
Pde6a [Search on AGR]
Homo sapiens This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Actl6a [Search on AGR]
Rattus norvegicus Predicted to enable chromatin binding activity. Involved in spinal cord development. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of chromatin. Orthologous to human ACTL6A (actin like 6A); PARTICIPATES IN altered SWI/SNF family mediated chromatin remodeling pathway; INO80 family mediated chromatin remodeling pathway; pancreatic cancer pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bis(2-ethylhexyl) phthalate.
Krt6c [Search on AGR]
Rattus norvegicus Predicted to be involved in intermediate filament cytoskeleton organization; morphogenesis of an epithelium; and wound healing. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to human KRT6A (keratin 6A); KRT6B (keratin 6B); and KRT6C (keratin 6C); INTERACTS WITH lead diacetate; N-nitrosomorpholine; 1-chloro-2,4-dinitrobenzene (ortholog).
utx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Involved in cell fate specification and programmed cell death. Part of MLL3/4 complex. Expressed in several structures, including germ line; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; breast cancer (multiple); and carcinoma (multiple). Is an ortholog of human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).
Pde6a [Search on AGR]
Rattus norvegicus Predicted to enable metal ion binding activity. Predicted to act upstream of or within photoreceptor cell maintenance and retina development in camera-type eye. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A); PARTICIPATES IN altered visual phototransduction pathway; retinitis pigmentosa pathway; visual phototransduction pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; furan.
Pex10 [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in cellular response to reactive oxygen species; protein import into peroxisome matrix, receptor recycling; and protein polyubiquitination. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 6A. Orthologous to human PEX10 (peroxisomal biogenesis factor 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; indometacin.
Clec6a-ps1 [Search on AGR]
Rattus norvegicus Predicted to enable calcium ion binding activity; mannose binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including detection of yeast; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to be active in plasma membrane. Orthologous to human CLEC6A (C-type lectin domain containing 6A); INTERACTS WITH Monobutylphthalate; (-)-alpha-phellandrene (ortholog); all-trans-retinoic acid (ortholog).
Sema6a [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of cell adhesion involved in sprouting angiogenesis; and negative regulation of signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and centrosome localization. Predicted to be located in plasma membrane. Orthologous to human SEMA6A (semaphorin 6A); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Kat6a [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in positive regulation of gene expression. Predicted to be located in cytosol and nuclear lumen. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Arboleda-Tham syndrome and acute myeloid leukemia. Orthologous to human KAT6A (lysine acetyltransferase 6A); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Cct6a [Search on AGR]
Rattus norvegicus Predicted to enable WD40-repeat domain binding activity and protein folding chaperone. Predicted to be involved in several processes, including positive regulation of protein localization; positive regulation of telomerase RNA localization to Cajal body; and positive regulation of telomere maintenance via telomerase. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in several cellular components, including acrosomal vesicle; cell body; and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT6A (chaperonin containing TCP1 subunit 6A); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Tnrc6a [Search on AGR]
Rattus norvegicus Predicted to enable nucleic acid binding activity. Predicted to be involved in miRNA-mediated gene silencing by inhibition of translation. Predicted to act upstream of or within cellular response to starvation and endoderm development. Predicted to be located in Golgi apparatus; P-body; and nucleoplasm. Predicted to be part of RISC complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A); PARTICIPATES IN microRNA pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Cln6 [Search on AGR]
Rattus norvegicus Predicted to enable lysophosphatidic acid binding activity; protein homodimerization activity; and sulfatide binding activity. Predicted to be involved in several processes, including cholesterol metabolic process; ganglioside metabolic process; and lysosomal lumen acidification. Predicted to act upstream of or within several processes, including locomotion involved in locomotory behavior; lysosome organization; and visual perception. Predicted to be located in several cellular components, including early endosome; endoplasmic reticulum lumen; and membrane raft. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis; neuronal ceroid lipofuscinosis 6A; and neuronal ceroid lipofuscinosis 6B. Orthologous to human CLN6 (CLN6 transmembrane ER protein); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.
Kdm6a [Search on AGR]
Rattus norvegicus Predicted to enable DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and identical protein binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; and positive regulation of cell size. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; bisphenol A.
Ncoa2 [Search on AGR]
Homo sapiens The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]