Part of dynactin complex. Human ortholog(s) of this gene implicated in Down syndrome and colon cancer. Is an ortholog of human ACTR1A (actin related protein 1A).
Is affected by several genes including daf-2; eat-2; and clk-1 based on microarray and RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in nuclear pore organization. Part of nuclear pore. Is an ortholog of human NDC1 (NDC1 transmembrane nucleoporin).
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of several human genes including SLC22A11 (solute carrier family 22 member 11); SLC22A14 (solute carrier family 22 member 14); and SLC22A4 (solute carrier family 22 member 4).
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in acute kidney failure and rheumatoid arthritis. Is an ortholog of several human genes including SLC22A14 (solute carrier family 22 member 14); SLC22A2 (solute carrier family 22 member 2); and SLC22A4 (solute carrier family 22 member 4).