Enriched in several structures, including GABAergic neurons; excretory cell; head mesodermal cell; neuronal sheath cell; and sensory neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
skn-1 based on microarray; RNA-seq; and proteomic studies. Is affected by nineteen chemicals including glutathione; 25-azacoprostane; and methylmercury hydroxide based on proteomic; RNA-seq; and microarray studies. Human HPGDS enables metal ion binding activity; prostaglandin-D synthase activity; and protein homodimerization activity. Is predicted to encode a protein with the following domains: Glutathione S-transferase, N-terminal; Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; Glutathione S-transferase, C-terminal domain superfamily; Glutathione S-transferase, C-terminal; and Thioredoxin-like superfamily. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).