Enables ATPase binding activity and single-stranded DNA helicase activity. Involved in DNA metabolic process. Predicted to be located in chromosome and nucleus. Is an ortholog of human HELQ (helicase, POLQ like).
Contributes to damaged DNA binding activity. Involved in nucleotide-excision repair and transcription by RNA polymerase II. Predicted to be located in chromosome and nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Expressed widely. Used to study trichothiodystrophy. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Is an ortholog of human GTF2H5 (general transcription factor IIH subunit 5).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).