eel-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; hemidesmosome assembly; and signal transduction in response to DNA damage. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including hermaphrodite gonad; intestine; neurons; pharynx; and vulva. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Is an ortholog of human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1).