pfk-1.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including 6-phosphofructokinase activity; carbohydrate derivative binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Expressed in germ line; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is an ortholog of human PFKL (phosphofructokinase, liver type) and PFKM (phosphofructokinase, muscle).
eif-1.A [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Expressed in head and tail. Is an ortholog of human EIF1AX (eukaryotic translation initiation factor 1A X-linked) and EIF1AY (eukaryotic translation initiation factor 1A Y-linked).
eef-1A.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Is an ortholog of human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).
icln-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in mRNA cis splicing, via spliceosome and spliceosomal snRNP assembly. Predicted to be located in cytosol. Predicted to be part of pICln-Sm protein complex and spliceosomal complex. Is an ortholog of human CLNS1A (chloride nucleotide-sensitive channel 1A).
C11E4.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be located in cytoplasm. Is an ortholog of human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) and ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B).
eef-1A.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity; GTPase activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Is an ortholog of human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).
ZK856.11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in nucleus. Is an ortholog of human EIF1AD (eukaryotic translation initiation factor 1A domain containing).
cor-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytoplasm and cytoskeleton. Expressed in several structures, including QL.a; QL.pa; QR.a; QR.pa; and oxygen sensory neurons. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Is an ortholog of several human genes including CORO1A (coronin 1A); CORO1B (coronin 1B); and CORO1C (coronin 1C).
num-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables enzyme binding activity and protein domain specific binding activity. Involved in endocytic recycling; phospholipid transport; and protein targeting to membrane. Located in basolateral plasma membrane and cytoplasm. Expressed in several structures, including alimentary muscle; hermaphrodite gonad; nerve ring; pseudocoelom; and rectal valve cell. Is an ortholog of human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein).
unc-85 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone binding activity. Involved in egg-laying behavior and post-embryonic development. Located in nucleus. Expressed in several structures, including germ line. Is an ortholog of human ASF1A (anti-silencing function 1A histone chaperone).
K04C2.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sequence-specific DNA binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleolus. Is an ortholog of human MYBBP1A (MYB binding protein 1a).
asfl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone binding activity. Involved in DNA replication and multicellular organismal reproductive process. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ASF1A (anti-silencing function 1A histone chaperone).
gck-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mitogen-activated protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of endocytic recycling; regulation of Golgi organization; and regulation of oocyte development. Located in cytoplasm and cytoplasmic side of apical plasma membrane. Used to study cerebral cavernous malformation. Is an ortholog of human STK26 (serine/threonine kinase 26).
rme-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol phosphate binding activity. Involved in endocytic recycling. Located in clathrin-coated pit. Expressed in several structures, including engulfing cell and linker cell. Is an ortholog of human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C).
sams-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Is an ortholog of human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A).
ppm-1.A [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of stress-activated MAPK cascade. Predicted to be located in cytosol and nucleus. Is an ortholog of human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) and PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B).
vti-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in macroautophagy and vesicle-mediated transport. Predicted to be located in endomembrane system. Predicted to be part of SNARE complex. Is an ortholog of human VTI1A (vesicle transport through interaction with t-SNAREs 1A).
Y18H1A.11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable choline-phosphate cytidylyltransferase activity and phosphatidylcholine binding activity. Predicted to be involved in CDP-choline pathway. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Is an ortholog of human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline).
sams-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in cytosol. Expressed in MI neuron. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Is an ortholog of human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A).
snt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calcium ion sensor activity and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 7. Is an ortholog of human SYT1 (synaptotagmin 1).
fos-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of stress response to copper ion; and regulation of gene expression. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including gonad; neurons; uterine pi cell; ventral uterine precursor; and vulval cell.
sams-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in cytosol. Expressed in pharyngeal gland cell. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Is an ortholog of human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A).
fkb-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Graves' disease. Is an ortholog of human FKBP1A (FKBP prolyl isomerase 1A); FKBP1B (FKBP prolyl isomerase 1B); and FKBP1C (FKBP prolyl isomerase family member 1C).
athp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Predicted to be involved in positive regulation of DNA replication; regulation of DNA-templated transcription; and regulation of heterochromatin formation. Predicted to be located in nuclear chromosome. Predicted to be part of ACF complex and CHRAC. Is an ortholog of human BAZ1A (bromodomain adjacent to zinc finger domain 1A).
sar-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activity. Involved in embryo development. Predicted to be located in endoplasmic reticulum exit site. Predicted to be part of COPII vesicle coat. Human ortholog(s) of this gene implicated in chylomicron retention disease. Is an ortholog of human SAR1A (secretion associated Ras related GTPase 1A) and SAR1B (secretion associated Ras related GTPase 1B).
dop-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables dopamine neurotransmitter receptor activity. Involved in adenylate cyclase-activating dopamine receptor signaling pathway. Predicted to be located in dendrite. Expressed in intestine; neurons; rectum; and vulva. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Is an ortholog of human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B).
npr-31 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Huntington's disease and type 2 diabetes mellitus. Is an ortholog of several human genes including APLNR (apelin receptor); MTNR1A (melatonin receptor 1A); and MTNR1B (melatonin receptor 1B).
tlk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of chromatin. Expressed in germ line; head; posterior lateral ganglion; somatic cell; and somatic gonad. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Is an ortholog of human TLK2 (tousled like kinase 2).
fog-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription corepressor activity. Involved in cell fate specification; developmental process involved in reproduction; and positive regulation of oocyte development. Located in cytoplasm and nuclear periphery. Expressed in germ line. Is an ortholog of human TOB1 (transducer of ERBB2, 1).
Or1a [Search on AGR]
Drosophila melanogaster Odorant receptor 1a (Or1a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals.
tal-1A [Search on AGR]
Drosophila melanogaster tarsal-less 1A (
tal-1A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization.
Vti1a [Search on AGR]
Drosophila melanogaster Vesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking.
Zc2hc1a [Search on AGR]
Rattus norvegicus Orthologous to human ZC2HC1A (zinc finger C2HC-type containing 1A); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; acetamide; bisphenol A.
myo-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans A structural constituent of muscle. Involved in muscle contraction and pharyngeal pumping. Located in striated muscle myosin thick filament. Expressed in pharynx. Human ortholog(s) of this gene implicated in several diseases, including contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A; distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
Irp-1A [Search on AGR]
Drosophila melanogaster Iron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs).
Irp-1B [Search on AGR]
Drosophila melanogaster Iron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A.
RhoGAP1A [Search on AGR]
Drosophila melanogaster Rho GTPase activating protein at 1A (RhoGAP1A) encodes a protein involved in Golgi organization and cell growth inhibition.
lron-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be located in extracellular matrix and extracellular space. Expressed in body wall musculature; head muscle; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 64; congenital stationary night blindness 1A; and stomach cancer. Is an ortholog of several human genes including LRRN1 (leucine rich repeat neuronal 1); LRRN2 (leucine rich repeat neuronal 2); and LRRN3 (leucine rich repeat neuronal 3).
lam-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in pharynx development and positive regulation of locomotion. Located in basement membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including Pierson syndrome; amelogenesis imperfecta type 1A; and lung carcinoma (multiple). Is an ortholog of human LAMB1 (laminin subunit beta 1) and LAMB2 (laminin subunit beta 2).
sptl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable serine C-palmitoyltransferase activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be located in endoplasmic reticulum. Expressed in head. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Is an ortholog of human SPTLC1 (serine palmitoyltransferase long chain base subunit 1).
seu-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in dorsal/ventral axon guidance and locomotion. Located in nucleus. Expressed in several structures, including hermaphrodite distal tip cell; intestine; pharynx; spermatheca; and ventral nerve cord.
fum-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Is an ortholog of human FH (fumarate hydratase).
C17orf107 [Search on AGR]
Homo sapiens ASSOCIATED WITH Abnormality of the musculature; congenital myasthenic syndrome; congenital myasthenic syndrome 1A; INTERACTS WITH 17beta-estradiol; aristolochic acid A; ozone
maph-1.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule depolymerization. Located in microtubule cytoskeleton. Expressed in body wall musculature; egg-laying apparatus; hypodermis; intestinal cell; and neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Is an ortholog of human MAP1A (microtubule associated protein 1A); MAP1B (microtubule associated protein 1B); and MAP1S (microtubule associated protein 1S).
pdfr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calcitonin family receptor activity. Involved in several processes, including locomotory behavior; signal transduction; and sleep. Located in plasma membrane. Expressed in several structures, including I1 neuron; RMEV; ganglia; mechanosensory neurons; and vulD. Human ortholog(s) of this gene implicated in bone disease (multiple); hereditary lymphedema; and primary failure of tooth eruption. Is an ortholog of human CALCR (calcitonin receptor); CALCRL (calcitonin receptor like receptor); and PTH1R (parathyroid hormone 1 receptor).
cpt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lymphangioleiomyomatosis. Is an ortholog of human CPT1A (carnitine palmitoyltransferase 1A) and CPT1C (carnitine palmitoyltransferase 1C).
ntr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in RMEV; ganglia; intestine; and oblique male muscle. Human ortholog(s) of this gene implicated in several diseases, including ACTH-secreting pituitary adenoma; X-linked recessive disease (multiple); and portal hypertension. Is an ortholog of several human genes including AVPR1A (arginine vasopressin receptor 1A); AVPR1B (arginine vasopressin receptor 1B); and AVPR2 (arginine vasopressin receptor 2).
Pced1a [Search on AGR]
Rattus norvegicus Predicted to enable transferase activity. Orthologous to human PCED1A (PC-esterase domain containing 1A); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Cimap1a [Search on AGR]
Rattus norvegicus Predicted to be located in outer dense fiber. Orthologous to human CIMAP1A (ciliary microtubule associated protein 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Npc1a [Search on AGR]
Drosophila melanogaster Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization.
maph-1.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule depolymerization. Predicted to be located in several cellular components, including cytosol; microtubule; and somatodendritic compartment. Predicted to be part of microtubule associated complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Is an ortholog of human MAP1A (microtubule associated protein 1A); MAP1B (microtubule associated protein 1B); and MAP1S (microtubule associated protein 1S).
Ankdd1a [Search on AGR]
Rattus norvegicus Predicted to be involved in signal transduction. Orthologous to human ANKDD1A (ankyrin repeat and death domain containing 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Dipk1a [Search on AGR]
Rattus norvegicus Predicted to be located in membrane. Orthologous to human DIPK1A (divergent protein kinase domain 1A); INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; bisphenol A.
maph-1.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule depolymerization. Predicted to be located in several cellular components, including cytosol; microtubule; and somatodendritic compartment. Predicted to be part of microtubule associated complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Is an ortholog of human MAP1A (microtubule associated protein 1A); MAP1B (microtubule associated protein 1B); and MAP1S (microtubule associated protein 1S).
Stx1a [Search on AGR]
Rattus norvegicus Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle exocytosis. Located in several cellular components, including actomyosin; postsynaptic density; and secretory granule. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; synaptic membrane; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
CenG1A [Search on AGR]
Drosophila melanogaster Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent.
D2030.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in ABprpapppa; germ line; germline precursor cell; hypodermis; and neurons based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including
daf-2;
daf-12; and
hsf-1 based on microarray; tiling array; and RNA-seq studies. Is affected by nine chemicals including manganese chloride; Zidovudine; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: SGNH hydrolase superfamily. Is an ortholog of human PCED1A (PC-esterase domain containing 1A) and PCED1B (PC-esterase domain containing 1B).
mans-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in carbohydrate metabolic process and protein glycosylation. Predicted to be located in Golgi membrane and endoplasmic reticulum. Is an ortholog of human MAN1A2 (mannosidase alpha class 1A member 2).
Ctr1A [Search on AGR]
Drosophila melanogaster Copper transporter 1A (Ctr1A) encodes a plasma membrane protein that functions as a copper transporter. It is required to drive neuropeptide maturation during normal growth and development.
mans-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in Golgi membrane and endoplasmic reticulum. Is an ortholog of human MAN1A1 (mannosidase alpha class 1A member 1).
prx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP hydrolysis activity. Predicted to be involved in protein import into peroxisome matrix. Predicted to be located in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 1; peroxisome biogenesis disorder 1A; and peroxisome biogenesis disorder 1B. Is an ortholog of human PEX1 (peroxisomal biogenesis factor 1).
LOC102552128 [Search on AGR]
Rattus norvegicus Predicted to be involved in keratinization. Orthologous to several human genes including LCE1A (late cornified envelope 1A); LCE1B (late cornified envelope 1B); and LCE1C (late cornified envelope 1C).
Garin1a [Search on AGR]
Rattus norvegicus Predicted to be involved in acrosome assembly. Predicted to be located in Golgi apparatus. Orthologous to human GARIN1A (golgi associated RAB2 interactor 1A); INTERACTS WITH bisphenol A; oxybenzone; paracetamol.
Mob1a [Search on AGR]
Rattus norvegicus Predicted to enable metal ion binding activity. Predicted to be involved in hippo signaling. Orthologous to human MOB1A (MOB kinase activator 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Cmtm7 [Search on AGR]
Mus musculus PHENOTYPE: Heterozygous mice die shortly after birth. Null mutations in this gene are haploinsufficient. A chimeric mouse showed defects in B-1a cell numbers and physiology. [provided by MGI curators]
Klhl14 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice heterozygous for the allele exhibit decreased B-1a cells and increased B-1b cells. [provided by MGI curators]
ntr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in intestine and neurons. Human ortholog(s) of this gene implicated in several diseases, including ACTH-secreting pituitary adenoma; X-linked recessive disease (multiple); and portal hypertension. Is an ortholog of several human genes including AVPR1A (arginine vasopressin receptor 1A); AVPR1B (arginine vasopressin receptor 1B); and AVPR2 (arginine vasopressin receptor 2).
unc-64 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein-folding chaperone binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Located in axon; basolateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including excretory gland cell; hermaphrodite gonad; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including Creutzfeldt-Jakob disease; Hirschsprung's disease; and generalized epilepsy with febrile seizures plus 9. Is an ortholog of human STX1A (syntaxin 1A).
pde-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and response to alkaline pH. Expressed in AFDL; AFDR; and head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Is an ortholog of human PDE1A (phosphodiesterase 1A) and PDE1B (phosphodiesterase 1B).
Gask1a [Search on AGR]
Rattus norvegicus Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Orthologous to human GASK1A (golgi associated kinase 1A); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Fhip1a [Search on AGR]
Rattus norvegicus Predicted to be involved in protein localization to perinuclear region of cytoplasm. Orthologous to human FHIP1A (FHF complex subunit HOOK interacting protein 1A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Tlr8 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased anti-nuclear antigen antibodies, altered immunoglobulin levels, decreased marginal zone, B-1a, and B-1b cells, splenomegaly, and glomerulonephritis. [provided by MGI curators]
pcyt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables choline-phosphate cytidylyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Expressed in head. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Is an ortholog of human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline).
Vamp2 [Search on AGR]
Rattus norvegicus Enables several functions, including calcium-dependent protein binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; exocytosis; and response to glucose. Located in neuron projection terminus; plasma membrane; and secretory vesicle. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in synaptic vesicle membrane. Orthologous to human VAMP2 (vesicle associated membrane protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin secretion pathway; vasopressin signaling pathway; INTERACTS WITH 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
let-526 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Involved in gonad development; nematode larval development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including excretory cell; gonad; pharynx; tail precursor cell; and vulva. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); carcinoma (multiple); and pre-eclampsia. Is an ortholog of human ARID1A (AT-rich interaction domain 1A).
pssy-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Is an ortholog of human PTDSS1 (phosphatidylserine synthase 1).
Cmtm7 [Search on AGR]
Rattus norvegicus Predicted to act upstream of or within B-1a B cell differentiation. Predicted to be located in membrane. Orthologous to human CMTM7 (CKLF like MARVEL transmembrane domain containing 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
GUCA1ANB-GUCA1A [Search on AGR]
Homo sapiens This locus represents naturally occurring readthrough transcription between the neighboring GUCA1ANB (GUCA1A neighbor) and GUCA1A (guanylate cyclase activator 1A) genes on chromosome 6. The readthrough transcript encodes the same protein as GUCA1A. [provided by RefSeq, Jul 2020]
lam-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in animal organ morphogenesis and tissue development. Located in basement membrane. Expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; and myopia. Is an ortholog of human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2).
ssu-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 1-hydroxypyrene sulfotransferase activity and aryl sulfotransferase activity. Involved in sulfur compound metabolic process. Located in cytosol. Expressed in ASJL and ASJR. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung non-small cell carcinoma (multiple); and reproductive organ cancer (multiple). Is an ortholog of several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1E1 (sulfotransferase family 1E member 1).
Adam1a [Search on AGR]
Rattus norvegicus Predicted to enable metal ion binding activity and metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in membrane raft. Orthologous to human ADAM1A (ADAM metallopeptidase domain 1A (pseudogene)); INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,4-dinitrotoluene.
nkcc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and monoatomic ion transmembrane transport. Predicted to be located in membrane. Expressed in body wall musculature; intestine; neurons; oocyte; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 78; middle cerebral artery infarction; and renal tubular transport disease (multiple). Is an ortholog of human SLC12A1 (solute carrier family 12 member 1) and SLC12A2 (solute carrier family 12 member 2).
set-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone H3K4 methyltransferase activity. Involved in determination of adult lifespan and transdifferentiation. Located in nucleus. Expressed in several structures, including germ line; hermaphrodite distal tip cell; intestine; and nerve ring. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with speech impairment and dysmorphic facies. Is an ortholog of human SETD1A (SET domain containing 1A, histone lysine methyltransferase).
Fbxl22 [Search on AGR]
Homo sapiens This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
Nyx [Search on AGR]
Rattus norvegicus Predicted to act upstream of or within visual perception. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1A and night blindness. Orthologous to human NYX (nyctalopin); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; copper atom.
Actr1a [Search on AGR]
Rattus norvegicus Predicted to enable ATP binding activity. Involved in spermatogenesis. Located in COPI-coated vesicle; centriole; and manchette. Orthologous to human ACTR1A (actin related protein 1A); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene; bisphenol A.
Snap25 [Search on AGR]
Rattus norvegicus Enables several functions, including calcium-dependent protein binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; long-term memory; and positive regulation of insulin secretion. Located in several cellular components, including axonal growth cone; lamellipodium; and presynaptic active zone membrane. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in glutamatergic synapse and presynaptic membrane. Is extrinsic component of presynaptic membrane. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 3,3',5,5'-tetrabromobisphenol A.
eIF1A [Search on AGR]
Rattus norvegicus Enables ribosomal large subunit binding activity. Predicted to be involved in translational initiation. Orthologous to human EIF1AY (eukaryotic translation initiation factor 1A Y-linked); PARTICIPATES IN translation initiation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Rac2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration. [provided by MGI curators]
Rasgef1a [Search on AGR]
Rattus norvegicus Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell migration and positive regulation of Ras protein signal transduction. Orthologous to human RASGEF1A (RasGEF domain family member 1A); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Roc1a [Search on AGR]
Drosophila melanogaster Regulator of cullins 1a (Roc1a) encodes a C2H2 type zinc finger protein and component of several Cullin-Ring E3 ubiquitin ligase complexes. It binds directly to the Cullin subunit within the CRL complex and functions to recruit ubiquitin-charged E2 proteins.
eIF1A [Search on AGR]
Drosophila melanogaster eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition.
SECTM1 [Search on AGR]
Homo sapiens This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]
dur-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in body wall musculature; cephalic sheath cell; germ line; muscle cell; and sensory neurons based on proteomic; tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including
daf-2;
skn-1; and
glp-1 based on proteomic; microarray; and RNA-seq studies. Is affected by twenty-five chemicals including methylmercury hydroxide; 1-methylnicotinamide; and rotenone based on RNA-seq; microarray; and proteomic studies.
C05D11.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in several structures, including ABalaapppa; ABalapaapa; ABplapaaap; ABprapaaap; and germ line based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-2;
daf-12; and
hsf-1 based on tiling array; RNA-seq; and microarray studies. Is affected by nine chemicals including aldicarb; rotenone; and D-glucose based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Family of unknown function (DUF5917); FHF complex subunit HOOK-interacting protein, C-terminal; FHF complex subunit HOOK interacting protein; Retinoic acid induced 16-like protein; and Phosphorylation site. Is an ortholog of human FHIP1A (FHF complex subunit HOOK interacting protein 1A) and FHIP1B (FHF complex subunit HOOK interacting protein 1B).
lsd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chromatin binding activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in several diseases, including alopecia areata; diabetic retinopathy; and hepatocellular carcinoma. Is an ortholog of human KDM1A (lysine demethylase 1A).
ceh-30 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of apoptotic process; nervous system development; and sex differentiation. Located in nucleus. Expressed in embryonic cell and neurons. Human ortholog(s) of this gene implicated in colorectal cancer; oral squamous cell carcinoma; and stomach cancer. Is an ortholog of human BARHL2 (BarH like homeobox 2).
Eif1ad [Search on AGR]
Rattus norvegicus Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human EIF1AD (eukaryotic translation initiation factor 1A domain containing); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Golt1a [Search on AGR]
Rattus norvegicus Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus subcompartment; endoplasmic reticulum; and nuclear envelope. Orthologous to human GOLT1A (golgi transport 1A); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Upk1a [Search on AGR]
Rattus norvegicus Predicted to be involved in epithelial cell differentiation. Predicted to be located in apical plasma membrane and cell surface. Predicted to be active in apical plasma membrane urothelial plaque. Orthologous to human UPK1A (uroplakin 1A); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Adra1a [Search on AGR]
Homo sapiens Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Dcp1a [Search on AGR]
Rattus norvegicus Enables kinesin binding activity. Predicted to be involved in methylguanosine-cap decapping and protein localization to cytoplasmic stress granule. Predicted to be located in P-body. Orthologous to human DCP1A (decapping mRNA 1A); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; gentamycin.
Dclre1a [Search on AGR]
Rattus norvegicus Predicted to enable 5'-3' DNA exonuclease activity and beta-lactamase activity. Predicted to act upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Mettl7a [Search on AGR]
Rattus norvegicus Predicted to enable mRNA (N6-adenosine)-methyltransferase activity. Predicted to be involved in nucleic acid metabolic process; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Serf1 [Search on AGR]
Rattus norvegicus Predicted to be involved in amyloid fibril formation and protein destabilization. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Orthologous to several human genes including SERF1A (small EDRK-rich factor 1A); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; amphetamine.
tpa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mitogen-activated protein kinase kinase kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; positive regulation of antimicrobial peptide production; and positive regulation of axon regeneration. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and portal hypertension. Is an ortholog of human PRKCD (protein kinase C delta) and PRKCQ (protein kinase C theta).
sams-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable methionine adenosyltransferase activity. Involved in negative regulation of lipid storage. Predicted to be located in cytosol. Expressed in body wall musculature; dorsal nerve cord; and ventral nerve cord. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Is an ortholog of human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A).
clh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Expressed in several structures, including amphid sensillum; anterior hypodermis; cephalic sheath cell; spermatheca; and vulval cell. Human ortholog(s) of this gene implicated in Thomsen disease; idiopathic generalized epilepsy 11; and primary hyperaldosteronism. Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2).
Ppp1r1a [Search on AGR]
Rattus norvegicus Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in glycogen metabolic process and signal transduction. Located in extracellular space. Orthologous to human PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A); PARTICIPATES IN long term potentiation; INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Tor1aip2 [Search on AGR]
Rattus norvegicus Predicted to enable ATPase activator activity and ATPase binding activity. Predicted to be involved in endoplasmic reticulum organization and protein localization to nuclear envelope. Predicted to be located in endoplasmic reticulum. Orthologous to human TOR1AIP2 (torsin 1A interacting protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.
Cyp27b1 [Search on AGR]
Rattus norvegicus Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Predicted to be located in cytoplasm. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1); PARTICIPATES IN steroid biosynthetic pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Zfy2-ps1 [Search on AGR]
Mus musculus PHENOTYPE: A sequence 83% identical to exon 1A of Zfy2 with promoter function does not map to Chr Y, and thus cannot be the first exon of Zfy1. Transcription during mouse preimplantation development differentiates this gene from Zfa, and it has been designated Zfy2-
ps1. [provided by MGI curators]
Uev1A [Search on AGR]
Drosophila melanogaster Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.
FCGR1CP [Search on AGR]
Homo sapiens The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009]
Ly16 [Search on AGR]
Mus musculus PHENOTYPE: The a allele of Ly16 determines Ly16.1 antigen in cytotoxic T-cells of BALB/c, C57L, C58; the b allele determines antigen absence in CBA/Tu, C57BL/6, SJL. Association of Ly16 and Igh-1a alleles in strains and congenics implies close genetic proximity. [provided by MGI curators]
PPA26170 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: SH3-like domain superfamily; Domain of unknown function DUF3447; SH3 domain; Ankyrin repeats (3 copies); Ankyrin repeat; Ankyrin repeat-containing domain superfamily; and Variant SH3 domain. Is an ortholog of C. elegans Y106G6H.14 and
eef-1A.1.
Mt1 [Search on AGR]
Rattus norvegicus Predicted to enable zinc ion binding activity. Involved in response to cadmium ion and response to zinc ion. Predicted to be located in cytoplasm and nucleus. Biomarker of kidney failure; median neuropathy; and transient cerebral ischemia. Orthologous to human MT1A (metallothionein 1A); INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Napa [Search on AGR]
Rattus norvegicus Enables syntaxin binding activity. Involved in protein-containing complex disassembly. Located in terminal bouton. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is active in neuromuscular junction; postsynapse; and presynaptic active zone membrane. Orthologous to human NAPA (NSF attachment protein alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 4,4'-sulfonyldiphenol.
Osbpl1a [Search on AGR]
Rattus norvegicus Predicted to enable cholesterol binding activity. Predicted to be involved in sterol transport. Predicted to be located in late endosome and organelle membrane contact site. Orthologous to human OSBPL1A (oxysterol binding protein like 1A); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
mbk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in several structures, including anterior gonad arm. Used to study Down syndrome and intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal obesity-metabolic syndrome 3; and autosomal dominant intellectual developmental disorder 7. Is an ortholog of human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
ser-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable alpha1-adrenergic receptor activity. Involved in several processes, including pharyngeal pumping; positive regulation of egg-laying behavior; and serotonin receptor signaling pathway. Predicted to be located in membrane. Expressed in body wall musculature; egg-laying apparatus; and lateral ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Is an ortholog of human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B).
EIF1AY [Search on AGR]
Homo sapiens This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Klhl14 [Search on AGR]
Homo sapiens The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]
Rprd1a [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity. Predicted to be involved in RNA polymerase II promoter clearance. Predicted to be located in nucleus. Predicted to be part of transcription preinitiation complex. Orthologous to human RPRD1A (regulation of nuclear pre-mRNA domain containing 1A); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
FKBP1A-SDCBP2 [Search on AGR]
Homo sapiens This locus represents naturally occurring read-through transcription between the neighboring FK506 binding protein 1A, 12kDa and syndecan binding protein (syntenin) 2 genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Dec 2010]
Niban3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele show impaired B-cell maturation, a reduction of B-1a cells, enhanced survival and proliferation of spleen B cells in response to stimulation, enhanced humoral immune responses, elevated levels of serum IgM and IgG3 antibodies and B-cell expansion in lymphoid organs. [provided by MGI curators]
Ghsr [Search on AGR]
Homo sapiens This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]
Gpr50 [Search on AGR]
Homo sapiens This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Map1a [Search on AGR]
Rattus norvegicus Enables actin binding activity; collagen binding activity; and microtubule binding activity. Involved in negative regulation of microtubule depolymerization. Located in several cellular components, including axon; dendrite; and neuronal cell body. Part of microtubule associated complex. Biomarker of hypothyroidism. Orthologous to human MAP1A (microtubule associated protein 1A); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Gramd1a [Search on AGR]
Rattus norvegicus Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. Orthologous to human GRAMD1A (GRAM domain containing 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
crm-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in plasma membrane. Expressed in PVR; cholinergic neurons; and intestine. Is an ortholog of human CRIM1 (cysteine rich transmembrane BMP regulator 1).
eff-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables fusogenic activity and identical protein binding activity. Involved in several processes, including anatomical structure morphogenesis; egg-laying behavior; and pharyngeal muscle development. Located in cell-cell contact zone; cytoplasm; and plasma membrane. Expressed in several structures, including P3.pa; P3.pp; hypodermis; tail spike; and vulval cell.
fem-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein phosphatase binding activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of germ cell proliferation; and sex determination. Located in protein-containing complex. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including germ line. Is an ortholog of human FEM1A (
fem-1 homolog A) and FEM1C (
fem-1 homolog C).
Sema1a [Search on AGR]
Drosophila melanogaster Semaphorin 1a (Sema1a) encodes a transmembrane protein belonging to the semaphorin protein family. It is a repulsive axon guidance cue, signaling through direct interactions with the receptor encoded by PlexA, and also functions as a receptor to regulate dendrite targeting and axon guidance. Secreted semaphorins encoded by Sema2a and Sema2b can act as the product of Sema1a ligands.
Cplx2 [Search on AGR]
Rattus norvegicus Enables calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynapse and presynapse. Orthologous to human CPLX2 (complexin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Mtnr1a [Search on AGR]
Rattus norvegicus Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Involved in camera-type eye development; circadian rhythm; and negative regulation of insulin secretion. Located in neuronal cell body. Biomarker of type 2 diabetes mellitus. Orthologous to human MTNR1A (melatonin receptor 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
dcap-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and response to heat. Located in P granule and P-body. Expressed in head; motor neurons; neurons; tail; and touch receptor neurons. Is an ortholog of human DCP1A (decapping mRNA 1A) and DCP1B (decapping mRNA 1B).
unc-104 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular component organization; and regulation of cellular localization. Located in axon; presynapse; and somatodendritic compartment. Expressed in epithelial cell; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and neuropathy (multiple). Is an ortholog of human KIF1A (kinesin family member 1A).
Cc2d1a [Search on AGR]
Homo sapiens This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]
Higd1a [Search on AGR]
Rattus norvegicus Predicted to act upstream of or within cellular response to glucose starvation; cellular response to hypoxia; and negative regulation of release of cytochrome c from mitochondria. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Ptf1a [Search on AGR]
Rattus norvegicus Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in exocrine pancreas development and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in pancreatic agenesis. Orthologous to human PTF1A (pancreas associated transcription factor 1a); INTERACTS WITH ammonium chloride; bisphenol A; sodium dichromate.
Ipo13 [Search on AGR]
Homo sapiens This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
Tpm2 [Search on AGR]
Rattus norvegicus Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Eif1ax [Search on AGR]
Rattus norvegicus Predicted to enable RNA binding activity. Predicted to be involved in ribosome assembly and translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. Predicted to be active in synapse. Orthologous to human EIF1AX (eukaryotic translation initiation factor 1A X-linked); PARTICIPATES IN translation initiation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Guca1a [Search on AGR]
Rattus norvegicus Predicted to enable calcium sensitive guanylate cyclase activator activity. Involved in positive regulation of cGMP-mediated signaling. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A); PARTICIPATES IN calcium/calcium-mediated signaling pathway; visual phototransduction pathway; INTERACTS WITH amitrole; bisphenol A; clotrimazole.
Kdm1a [Search on AGR]
Rattus norvegicus Enables chromatin binding activity. Involved in several processes, including cellular response to cAMP; nervous system development; and positive regulation of cell size. Part of chromatin. Biomarker of breast cancer; diabetic retinopathy; schizophrenia; and transient cerebral ischemia. Orthologous to human KDM1A (lysine demethylase 1A); PARTICIPATES IN histone modification pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aldehydo-D-glucose; bisphenol A.
Mat1a [Search on AGR]
Rattus norvegicus Enables several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and protein-containing complex assembly. Located in nuclear matrix. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A); PARTICIPATES IN methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Coro1a [Search on AGR]
Rattus norvegicus Predicted to enable cytoskeletal protein binding activity; phosphatidylinositol 3-kinase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including natural killer cell degranulation; negative regulation of actin nucleation; and negative regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including early endosome to recycling endosome transport; nerve growth factor signaling pathway; and regulation of organelle organization. Predicted to be located in several cellular components, including actin filament; cytoplasmic vesicle; and immunological synapse. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and stereocilium tip. Predicted to colocalize with cortical actin cytoskeleton. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to human CORO1A (coronin 1A); PARTICIPATES IN phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cplx1 [Search on AGR]
Rattus norvegicus Enables syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Chrna1 [Search on AGR]
Rattus norvegicus Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH acetylcholine; acrylamide; ammonium chloride.
Clp1 [Search on AGR]
Saccharomyces cerevisiae Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription; mutations in human ortholog cause cerebellar neurodegeneration
Pcyt1a [Search on AGR]
Rattus norvegicus Enables several functions, including calmodulin binding activity; choline-phosphate cytidylyltransferase activity; and phosphatidylcholine binding activity. Involved in CDP-choline pathway. Located in nuclear envelope. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline); PARTICIPATES IN glycerophospholipid metabolic pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Zng1a [Search on AGR]
Rattus norvegicus Predicted to enable GTPase activity and zinc chaperone activity. Predicted to be involved in intracellular zinc ion homeostasis; kidney development; and protein maturation. Predicted to be located in nucleus. Orthologous to several human genes including ZNG1A (Zn regulated GTPase metalloprotein activator 1A); ZNG1C (Zn regulated GTPase metalloprotein activator 1C); and ZNG1E (Zn regulated GTPase metalloprotein activator 1E); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Gabarap [Search on AGR]
Homo sapiens Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Ppp1r9b [Search on AGR]
Homo sapiens This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]
Tor1aip1 [Search on AGR]
Rattus norvegicus Enables lamin binding activity. Predicted to be involved in protein localization to nucleus. Predicted to act upstream of or within nuclear membrane organization and protein localization to nuclear envelope. Located in nuclear envelope. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Y. Orthologous to human TOR1AIP1 (torsin 1A interacting protein 1); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Tuba1a [Search on AGR]
Rattus norvegicus Enables protein domain specific binding activity. Predicted to be involved in several processes, including learning or memory; microtubule cytoskeleton organization; and nervous system development. Located in membrane raft and myelin sheath. Human ortholog(s) of this gene implicated in lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
lgg-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2).
pmt-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatidyl-N-dimethylethanolamine N-methyltransferase activity and phosphatidyl-N-methylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Is an ortholog of human TMT1A (thiol methyltransferase 1A) and TMT1B (thiol methyltransferase 1B).
sup-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. Is an ortholog of human RBM24 (RNA binding motif protein 24) and RBM38 (RNA binding motif protein 38).
Pde1a [Search on AGR]
Rattus norvegicus Enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process; regulation of smooth muscle cell apoptotic process; and regulation of smooth muscle cell proliferation. Located in neuronal cell body. Orthologous to human PDE1A (phosphodiesterase 1A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; calcium/calcium-mediated signaling pathway; purine metabolic pathway; INTERACTS WITH 3',5'-cyclic GMP; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Vwa2 [Search on AGR]
Homo sapiens This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]
YJR107C-A [Search on AGR]
Saccharomyces cerevisiae Protein of unknown function; encodes new type of domain, which ab initio modeling suggests is predominantly alpha-helical; nonessential for growth, deletion increases sensitivity to osmostress; expressed at moderate to high abundance; ORF also present in strains EC1118, YJM789, RM11-1a, and AWRI1631; Gln24 in S288C reference is substituted with Arg in wine strain EC1118; predicted S-palmitoylation site on Cys2, suggesting membrane association; transcript previously mischaracterized as SUT646
Baz1a [Search on AGR]
Rattus norvegicus Predicted to enable metal ion binding activity. Predicted to be involved in DNA-templated DNA replication; nucleosome assembly; and positive regulation of DNA replication. Predicted to be located in nuclear chromosome. Predicted to be part of ACF complex; CHRAC; and pericentric heterochromatin. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A); PARTICIPATES IN ISWI family mediated chromatin remodeling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Clns1a [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including lipid binding activity; monoatomic ion channel activity; and splicing factor binding activity. Involved in cell volume homeostasis and chloride transport. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of methylosome and pICln-Sm protein complex. Orthologous to human CLNS1A (chloride nucleotide-sensitive channel 1A); PARTICIPATES IN RNA transport pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; ammonium chloride; bisphenol A.
Fkbp1a [Search on AGR]
Rattus norvegicus Enables several functions, including FK506 binding activity; Hsp70 protein binding activity; and type I transforming growth factor beta receptor binding activity. Involved in response to iron ion. Located in axon terminus. Biomarker of Parkinsonism. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A); PARTICIPATES IN activin signaling pathway; mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
RNA15 [Search on AGR]
Saccharomyces cerevisiae Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability
Sh2d1a [Search on AGR]
Rattus norvegicus Predicted to be involved in negative regulation of T cell receptor signaling pathway. Predicted to act upstream of or within humoral immune response and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 1. Orthologous to human SH2D1A (SH2 domain containing 1A); PARTICIPATES IN measles pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Dpp4 [Search on AGR]
Rattus norvegicus Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in B-1a B cell differentiation; protein catabolic process; and regulation of lymphocyte mediated immunity. Located in cell surface. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Dyrk1a [Search on AGR]
Rattus norvegicus Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in positive regulation of RNA splicing and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Man1a2 [Search on AGR]
Rattus norvegicus Predicted to enable calcium ion binding activity. Predicted to be involved in carbohydrate metabolic process. Predicted to act upstream of or within glycoprotein metabolic process; lung alveolus development; and respiratory gaseous exchange by respiratory system. Predicted to be located in Golgi membrane. Orthologous to human MAN1A2 (mannosidase alpha class 1A member 2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Vrk1 [Search on AGR]
Rattus norvegicus Predicted to enable histone H3 kinase activity; histone binding activity; and protein kinase binding activity. Predicted to be involved in DNA damage response; Golgi disassembly; and positive regulation of protein localization to chromatin. Predicted to be located in Golgi stack; cytosol; and nuclear lumen. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Ggn [Search on AGR]
Homo sapiens This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
lev-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in several structures, including DD neuron; anal depressor muscle; ganglia; head neurons; and uterine-vulval cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit).
ifb-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Located in apical plasma membrane. Expressed in several structures, including egg-laying apparatus; excretory system; pharyngeal-intestinal valve; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2).
Man1a1 [Search on AGR]
Rattus norvegicus Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in protein targeting to ER and ubiquitin-dependent ERAD pathway. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Smc1a [Search on AGR]
Rattus norvegicus Predicted to enable chromatin binding activity; mediator complex binding activity; and protein heterodimerization activity. Involved in meiotic cell cycle. Located in lateral element and nucleoplasm. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to human SMC1A (structural maintenance of chromosomes 1A); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1,2-dimethylhydrazine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Lama2 [Search on AGR]
Rattus norvegicus Predicted to enable signaling receptor binding activity. Involved in Schwann cell differentiation. Located in basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Vti1a [Search on AGR]
Rattus norvegicus Predicted to enable SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; synaptic vesicle to endosome fusion; and vesicle fusion with Golgi apparatus. Located in several cellular components, including clathrin-coated vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of SNARE complex. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
RNA14 [Search on AGR]
Saccharomyces cerevisiae Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia
Anks1a [Search on AGR]
Rattus norvegicus Predicted to enable ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Predicted to be located in cytosol; neuron projection; and nucleoplasm. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A); INTERACTS WITH 6-propyl-2-thiouracil; aconitine; amitrole.
Rcbtb1 [Search on AGR]
Homo sapiens This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]
Scgb1a1 [Search on AGR]
Rattus norvegicus Enables polychlorinated biphenyl binding activity. Involved in several processes, including response to lipopolysaccharide; response to ozone; and response to silicon dioxide. Located in extracellular space; nuclear envelope; and secretory granule. Biomarker of acute kidney failure; asthma; otitis media; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; and glomerulonephritis. Orthologous to human SCGB1A1 (secretoglobin family 1A member 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
cast [Search on AGR]
Rattus norvegicus Enables calcium-dependent cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ regeneration; egg activation; and myoblast fusion. Located in membrane and postsynaptic density. Used to study brain ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Arid1b [Search on AGR]
Homo sapiens This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Dennd1a [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including SH3 domain binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in endocytic recycling; endocytosis; and regulation of Rab protein signal transduction. Predicted to act upstream of or within synaptic vesicle endocytosis. Predicted to be located in several cellular components, including clathrin-coated vesicle membrane; dendrite; and neuronal cell body. Orthologous to human DENND1A (DENN domain containing 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; bisphenol A.
unc-68 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Expressed in body wall musculature; intestine; neurons; and non-striated muscle. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; intracranial vasospasm; and muscle tissue disease (multiple). Is an ortholog of human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3).
asd-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in P granule and nucleus. Part of ribonucleoprotein complex. Expressed in body wall musculature; hypodermis; and pharyngeal muscle cell. Is an ortholog of human QKI (QKI, KH domain containing RNA binding).
mab-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ADF; SMD; and in male.
vrk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase activity. Involved in several processes, including cell fate specification; gonad development; and regulation of fibroblast growth factor receptor signaling pathway. Located in nuclear envelope. Part of chromatin. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite gonad; and ventral nerve cord. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Is an ortholog of human VRK1 (VRK serine/threonine kinase 1).
SLX1A-SULT1A3 [Search on AGR]
Homo sapiens This locus represents naturally occurring read-through transcription between the neighboring SLX1A (SLX1 structure-specific endonuclease subunit homolog A) and SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) genes on the short arm of chromosome 16. A duplicate read-through locus also exists between the SLX1B and SULT1A4 genes located approximately 730 kb upstream on the same chromosome. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2017]
Cstb [Search on AGR]
Rattus norvegicus Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in amyloid fibril formation and negative regulation of proteolysis. Predicted to act upstream of or within adult locomotory behavior. Predicted to be located in cytosol; extracellular space; and nucleolus. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome and progressive myoclonus epilepsy 1A. Orthologous to human CSTB (cystatin B); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Lamb3 [Search on AGR]
Rattus norvegicus Predicted to be involved in endodermal cell differentiation. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in basement membrane. Predicted to be part of laminin-5 complex. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3); PARTICIPATES IN cell-extracellular matrix signaling pathway; Entamoebiasis pathway; small cell lung carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
SLX1B-SULT1A4 [Search on AGR]
Homo sapiens This locus represents naturally occurring read-through transcription between the neighboring SLX1B (SLX1 structure-specific endonuclease subunit homolog B) and SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) genes on the short arm of chromosome 16. A duplicate read-through locus also exists between the SLX1A and SULT1A3 genes located approximately 730 kb downstream on the same chromosome. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2017]
Fkbp1b [Search on AGR]
Homo sapiens The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
5-HT1A [Search on AGR]
Drosophila melanogaster 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT1A has been implicated in several aspects of adult behavior, including baseline sleep, aggression, courtship, as well as memory formation.
Fhl1 [Search on AGR]
Rattus norvegicus Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; positive regulation of potassium ion transport; and regulation of membrane depolarization. Predicted to be located in cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Mybbp1A [Search on AGR]
Rattus norvegicus Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; positive regulation of anoikis; and regulation of gene expression. Predicted to act upstream of with a negative effect on regulation of G1 to G0 transition. Predicted to act upstream of or within respiratory electron transport chain. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of B-WICH complex and NLS-dependent protein nuclear import complex. Orthologous to human MYBBP1A (MYB binding protein 1a); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
pex1 [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ubiquitin-dependent protein binding activity. Predicted to be involved in protein import into peroxisome matrix, receptor recycling; protein targeting to peroxisome; and protein unfolding. Predicted to act upstream of or within microtubule-based peroxisome localization. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 1; peroxisome biogenesis disorder 1A; and peroxisome biogenesis disorder 1B. Orthologous to human PEX1 (peroxisomal biogenesis factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.
Sult1a1 [Search on AGR]
Rattus norvegicus Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity; aryl sulfotransferase activity; and identical protein binding activity. Involved in several processes, including 4-nitrophenol metabolic process; estrogen metabolic process; and response to activity. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); PARTICIPATES IN lamivudine pharmacokinetics pathway; paracetamol pharmacokinetics pathway; sulfite oxidase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (S)-naringenin; 1,2-dimethylhydrazine.
Txlng [Search on AGR]
Homo sapiens This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Map1a [Search on AGR]
Homo sapiens This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Myh3 [Search on AGR]
Rattus norvegicus Predicted to enable ATP hydrolysis activity; actin filament binding activity; and microfilament motor activity. Predicted to be involved in ATP metabolic process and skeletal muscle contraction. Predicted to be located in contractile fiber. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A; contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B; distal arthrogryposis type 2A; distal arthrogryposis type 2B; and distal arthrogryposis type 2B3. Orthologous to human MYH3 (myosin heavy chain 3); PARTICIPATES IN myocarditis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Adra1d [Search on AGR]
Homo sapiens Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Asf1a [Search on AGR]
Rattus norvegicus Predicted to enable chromatin binding activity; histone binding activity; and histone chaperone activity. Predicted to be involved in DNA repair-dependent chromatin remodeling and replication fork processing. Predicted to act upstream of or within several processes, including DNA repair; nucleosome assembly; and osteoblast differentiation. Predicted to be located in nucleoplasm. Predicted to be part of chromatin. Predicted to be active in site of double-strand break. Orthologous to human ASF1A (anti-silencing function 1A histone chaperone); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cpt1a [Search on AGR]
Rattus norvegicus Enables carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including fatty acid metabolic process; liver regeneration; and response to tetrachloromethane. Located in mitochondrial outer membrane. Biomarker of alcoholic hepatitis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (R)-carnitine.
Kif1a [Search on AGR]
Rattus norvegicus Enables identical protein binding activity and microtubule binding activity. Involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in several cellular components, including microtubule; neuronal cell body; and secretory vesicle. Part of protein-containing complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A); INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; aldehydo-D-glucose.
Ppm1a [Search on AGR]
Rattus norvegicus Enables phosphoprotein phosphatase activity and transmembrane transporter binding activity. Predicted to be involved in dephosphorylation; positive regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to act upstream of or within cellular response to transforming growth factor beta stimulus; negative regulation of BMP signaling pathway; and positive regulation of protein export from nucleus. Located in neuron projection. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acrylamide.
spr-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Involved in epigenetic regulation of gene expression. Located in cytoplasm and nucleus. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including alopecia areata; diabetic retinopathy; and hepatocellular carcinoma. Is an ortholog of human KDM1A (lysine demethylase 1A).
Avpr1a [Search on AGR]
Rattus norvegicus Enables V1A vasopressin receptor binding activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in several processes, including grooming behavior; maternal aggressive behavior; and regulation of blood circulation. Predicted to be located in endocytic vesicle; endosome; and plasma membrane. Used to study acute kidney failure; brain edema; and myocardial infarction. Biomarker of hypertension and renovascular hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human AVPR1A (arginine vasopressin receptor 1A); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 1; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Slx1b [Search on AGR]
Homo sapiens This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010]
Sdcbp2 [Search on AGR]
Homo sapiens The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]
Arpc1a [Search on AGR]
Rattus norvegicus Predicted to enable actin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in muscle cell projection membrane; nucleus; and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
SLX1A [Search on AGR]
Homo sapiens This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]
tat-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including lysosome organization; phospholipid translocation; and regulation of phagocytosis, engulfment. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and endosome. Expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Is an ortholog of human ATP8A2 (ATPase phospholipid transporting 8A2).
ooc-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in cellular response to misfolded protein. Located in several cellular components, including endoplasmic reticulum; perinuclear region of cytoplasm; and spindle. Expressed in several structures, including CAN; intestine; pharyngeal-intestinal valve; pharynx; and rectal gland cell. Used to study torsion dystonia 1. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Is an ortholog of human TOR1A (torsin family 1 member A) and TOR1B (torsin family 1 member B).
arx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); immunodeficiency 71; and myelodysplastic syndrome. Is an ortholog of human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B).
Chmp1a [Search on AGR]
Rattus norvegicus Predicted to enable protein domain specific binding activity and protein homodimerization activity. Predicted to be involved in several processes, including midbody abscission; plasma membrane repair; and regulation of cell cycle process. Predicted to act upstream of or within mitotic chromosome condensation and negative regulation of gene expression. Predicted to be located in several cellular components, including bounding membrane of organelle; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 8. Orthologous to human CHMP1A (charged multivesicular body protein 1A); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 2-methoxyethanol.
Gjb6 [Search on AGR]
Rattus norvegicus Predicted to enable cytoskeletal protein binding activity and gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including cellular response to glucose stimulus; response to electrical stimulus; and response to lipopolysaccharide. Located in apical plasma membrane and gap junction. Biomarker of borna disease; status epilepticus; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in Clouston syndrome; autosomal dominant nonsyndromic deafness 3B; autosomal recessive nonsyndromic deafness 1A; autosomal recessive nonsyndromic deafness 1B; and ectodermal dysplasia. Orthologous to human GJB6 (gap junction protein beta 6); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Cacna1a [Search on AGR]
Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Hspa1a [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including response to ethanol; response to ischemia; and response to unfolded protein. Located in membrane raft. Biomarker of graft-versus-host disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and vascular dementia. Orthologous to human HSPA1A (heat shock protein family A (Hsp70) member 1A); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (R)-lipoic acid; 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate.
Zfhx3 [Search on AGR]
Homo sapiens This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as
p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Htr1a [Search on AGR]
Rattus norvegicus Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and negative regulation of gamma-aminobutyric acid secretion. Located in axon hillock. Is active in GABA-ergic synapse and presynaptic membrane. Used to study Parkinson's disease and panic disorder. Human ortholog(s) of this gene implicated in anxiety disorder; depressive disorder; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1-(3-chlorophenyl)piperazine.
Sptlc1 [Search on AGR]
Rattus norvegicus Predicted to enable pyridoxal phosphate binding activity. Predicted to contribute to serine C-palmitoyltransferase activity. Predicted to be involved in regulation of fat cell apoptotic process and sphingolipid metabolic process. Predicted to act upstream of or within positive regulation of lipophagy and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of SPOTS complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
ser-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables G protein-coupled serotonin receptor activity. Involved in regulation of locomotion and serotonin receptor signaling pathway. Predicted to be located in dendrite. Expressed in neurons;
vm2; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; attention deficit hyperactivity disorder; conduct disorder; and panic disorder. Is an ortholog of human HTR1A (5-hydroxytryptamine receptor 1A).
hmr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Expressed in several structures, including germline precursor cell; hypodermis; motor neurons; nerve ring; and neuroblasts.
dmd-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; neuron differentiation; and regulation of reproductive process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in neuronal cell body. Expressed in several structures, including PHC; epithelial cell; gonad; ray neuron type A; and tail hypodermis. Is an ortholog of human DMRTB1 (DMRT like family B with proline rich C-terminal 1).
fln-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Involved in several processes, including axon development; semaphorin-plexin signaling pathway; and uterus morphogenesis. Located in actin filament. Expressed in body wall musculature; gonad; hypodermis; intestine; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); bone development disease (multiple); distal muscular dystrophy 4; and heart valve disease (multiple). Is an ortholog of human FLNB (filamin B) and FLNC (filamin C).
Adra1b [Search on AGR]
Homo sapiens Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
Cc2d1a [Search on AGR]
Rattus norvegicus Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of snRNA transcription by RNA polymerase II and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within endosome organization; negative regulation of transcription by RNA polymerase II; and regulation of respiratory gaseous exchange by nervous system process. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 3 and intellectual disability. Orthologous to human CC2D1A (coiled-coil and C2 domain containing 1A); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; allethrin.
Krit1 [Search on AGR]
Homo sapiens This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
zmp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24).
Bmpr1a [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including ATP binding activity; BMP binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of cell population proliferation; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including limb morphogenesis; regionalization; and regulation of gene expression. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 17alpha-ethynylestradiol; acrylamide.
Adra1a [Search on AGR]
Rattus norvegicus Enables alpha1-adrenergic receptor activity. Involved in several processes, including calcium ion transport into cytosol; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (R)-adrenaline; (R)-noradrenaline.
Cdkn1a [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to hyperoxia; and response to mineralocorticoid. Located in perinuclear region of cytoplasm. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Cacna1d [Search on AGR]
Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Eml1 [Search on AGR]
Homo sapiens Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Setd1a [Search on AGR]
Rattus norvegicus Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; beta-catenin binding activity; and histone H3K4 methyltransferase activity. Predicted to be involved in several processes, including regulation of chromatin organization; regulation of erythrocyte differentiation; and regulation of hematopoietic stem cell differentiation. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; and stem cell population maintenance. Predicted to be located in nuclear speck. Predicted to be part of Set1C/COMPASS complex and euchromatin. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with speech impairment and dysmorphic facies. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; INTERACTS WITH fenvalerate; 1,2-dimethylhydrazine (ortholog); 17beta-estradiol (ortholog).
Srebf1 [Search on AGR]
Homo sapiens This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Arid1a [Search on AGR]
Rattus norvegicus Predicted to enable ATP-dependent chromatin remodeler activity; DNA binding activity; and nuclear receptor binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in intracellular steroid hormone receptor signaling pathway; nucleosome disassembly; and positive regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including circulatory system development; embryo implantation; and embryonic morphogenesis. Predicted to be located in nucleoplasm. Predicted to be part of SWI/SNF complex; nBAF complex; and npBAF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 2; breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neuroblastoma. Orthologous to human ARID1A (AT-rich interaction domain 1A); PARTICIPATES IN altered SWI/SNF family mediated chromatin remodeling pathway; pancreatic cancer pathway; SWI/SNF family mediated chromatin remodeling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Tnfrsf1a [Search on AGR]
Rattus norvegicus Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in axon; cell surface; and extracellular space. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ceramide signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
RpS29 [Search on AGR]
Homo sapiens Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Cox10 [Search on AGR]
Homo sapiens Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
Fkbp4 [Search on AGR]
Homo sapiens The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (
hsp90 and
hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Gnas [Search on AGR]
Homo sapiens This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]