Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ubiquitin ligase complex. Is an ortholog of human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1).
Involved in several processes, including determination of adult lifespan; negative regulation of autophagy; and response to heat. Expressed in excretory canal; hypodermis; neurons; somatic nervous system; and vulval precursor cell.
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.
Predicted to enable guanylate cyclase activity. Involved in chemosensory behavior and sensory perception of bitter taste. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.