- gex-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA 7-methylguanosine cap binding activity. Involved in several processes, including embryonic body morphogenesis; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell junction. Part of SCAR complex. Human ortholog(s) of this gene implicated in several diseases, including Schaaf-Yang syndrome; autism spectrum disorder; and epilepsy (multiple). Is an ortholog of human CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2).
- Zzef1 [Search on AGR]
Rattus norvegicus Predicted to enable histone binding activity; histone reader activity; and ubiquitin-like protein ligase activity. Predicted to be involved in chromatin organization. Predicted to act upstream of or within several processes, including glutamatergic synaptic transmission; neuroblast proliferation; and visual learning. Predicted to be located in cell surface; postsynapse; and presynaptic active zone. Orthologous to human ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
- Zzz3 [Search on AGR]
Rattus norvegicus Predicted to enable histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Predicted to be involved in several processes, including regulation of embryonic development; regulation of transcription by RNA polymerase II; and regulation of tubulin deacetylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of ATAC complex. Orthologous to human ZZZ3 (zinc finger ZZ-type containing 3); PARTICIPATES IN RNA polymerase II transcription initiation pathway; INTERACTS WITH bisphenol A; methimazole; oxaliplatin.
- Magel2 [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; protein K63-linked ubiquitination; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within positive regulation of actin nucleation. Predicted to be located in endosome and nucleus. Predicted to be part of retromer complex. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
- Dytn [Search on AGR]
Homo sapiens This gene belongs to the dystrophin superfamily, which is characterized by the presence of four EF-hand motifs and a ZZ-domain. It is a likely ortholog of the Drosophila 'discontinuous actin hexagon' gene. It is noteworthy that the coding region of this gene lacks two coding exons that are found in the mouse ortholog. Human transcripts including these two exons are subject to nonsense-mediated transcript decay (NMD). On the other hand, transcripts skipping the two coding exons are expressed at very low levels. While this gene maintains an intact CDS, it may be an evolving pseudogene. However, after a discussion about this gene within the RefSeq group, as well as in the consensus coding sequence (CCDS) collaboration, it was decided to keep it as a protein-coding gene in the RefSeq, Ensembl-GENCODE and the CCDS sets. [provided by RefSeq, Jul 2019]