rbr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity. Involved in determination of adult lifespan and regulation of vulval development. Located in nucleus. Expressed in several structures, including anchor cell and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of musculoskeletal system (multiple); gastrointestinal system cancer (multiple); and intellectual disability (multiple). Is an ortholog of several human genes including KDM5A (lysine demethylase 5A); KDM5C (lysine demethylase 5C); and KDM5D (lysine demethylase 5D).