let-60 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTP binding activity; phospholipase binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including learning or memory; positive regulation of receptor localization to synapse; and positive regulation of vulval development. Located in cell cortex. Expressed in several structures, including gonad; head neurons; pharyngeal muscle cell; vulval cell; and vulval precursor cell. Used to study RASopathy and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); and malignant astrocytoma (multiple). Is an ortholog of human HRAS (HRas proto-oncogene, GTPase).