- arx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Located in cell leading edge and cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); glioblastoma; and opisthorchiasis. Is an ortholog of human ACTR3 (actin related protein 3).
- arx-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity. Predicted to contribute to actin filament binding activity. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Located in striated muscle dense body. Human ortholog(s) of this gene implicated in diabetes mellitus. Is an ortholog of human ARPC3 (actin related protein 2/3 complex subunit 3).
- arx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); immunodeficiency 71; and myelodysplastic syndrome. Is an ortholog of human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B).
- arx-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Arp2/3 protein complex. Expressed in Q cell; anchor cell; apoptotic cell; seam cell; and socket cell. Human ortholog(s) of this gene implicated in colorectal carcinoma. Is an ortholog of human ACTR2 (actin related protein 2).
- arx-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including colorectal adenocarcinoma; invasive ductal carcinoma; and systemic scleroderma. Is an ortholog of human ARPC2 (actin related protein 2/3 complex subunit 2).
- arx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in Down syndrome. Is an ortholog of human ARPC4 (actin related protein 2/3 complex subunit 4).
- arx-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; epithelial cell migration; and morphogenesis of embryonic epithelium. Located in cytoplasm. Expressed in anchor cell; hypodermis; and linker cell. Human ortholog(s) of this gene implicated in lung squamous cell carcinoma. Is an ortholog of human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like).
- alr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including amphid sensory organ development; epidermis morphogenesis; and sensory perception of touch. Located in nucleus. Expressed in several structures, including anterior hypodermis; neurons; pseudocoelom; socket cell; and somatic nervous system. Used to study non-syndromic X-linked intellectual disability 1. Human ortholog(s) of this gene implicated in several diseases, including X-linked lissencephaly 2; X-linked recessive disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human ALX4 (ALX homeobox 4) and ARX (aristaless related homeobox).
- klc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable kinesin binding activity. Involved in establishment of meiotic spindle localization and polar body extrusion after meiotic divisions. Predicted to be located in cytoplasm. Predicted to be part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1).